{"id":"https://openalex.org/W2467338186","doi":"https://doi.org/10.1007/s12195-016-0456-5","title":"Cholesterol Enrichment Impairs Capacitative Calcium Entry, eNOS Phosphorylation & Shear Stress-Induced NO Production","display_name":"Cholesterol Enrichment Impairs Capacitative Calcium Entry, eNOS Phosphorylation & Shear Stress-Induced NO Production","publication_year":2016,"publication_date":"2016-07-06","ids":{"openalex":"https://openalex.org/W2467338186","doi":"https://doi.org/10.1007/s12195-016-0456-5","mag":"2467338186","pmid":"https://pubmed.ncbi.nlm.nih.gov/28138348"},"language":"en","primary_location":{"id":"doi:10.1007/s12195-016-0456-5","doi":"https://doi.org/10.1007/s12195-016-0456-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12195-016-0456-5","pdf_url":null,"source":{"id":"https://openalex.org/S77874066","display_name":"Cellular and Molecular Bioengineering","issn_l":"1865-5025","issn":["1865-5025","1865-5033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5270765","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084190685","display_name":"Allison Michelle Andrews","orcid":"https://orcid.org/0000-0003-1752-7450","observed_orcids":["https://orcid.org/0000-0003-1752-7450"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allison M. Andrews","raw_affiliation_strings":["Department of Pathology & Laboratory Medicine, Lewis Katz School of Medicine at Temple University, 3500N. Broad St., Philadelphia, PA 19140, USA","Department of Pathology & Laboratory Medicine, Lewis Katz School of Medicine at Temple University, 3500N. Broad St., Philadelphia, PA, 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Laboratory Medicine, Lewis Katz School of Medicine at Temple University, 3500N. Broad St., Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Pathology & Laboratory Medicine, Lewis Katz School of Medicine at Temple University, 3500N. Broad St., Philadelphia, PA, 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072355739","display_name":"Tenderano T. Muzorewa","orcid":"https://orcid.org/0000-0003-0536-3671","observed_orcids":["https://orcid.org/0000-0003-0536-3671"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tenderano T. Muzorewa","raw_affiliation_strings":["School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA 19104, USA","School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080111728","display_name":"Kelly A. Zaccheo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly A. Zaccheo","raw_affiliation_strings":["School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA 19104, USA","School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051078373","display_name":"Donald G. Buerk","orcid":"https://orcid.org/0000-0002-7037-1945","observed_orcids":["https://orcid.org/0000-0002-7037-1945"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald G. Buerk","raw_affiliation_strings":["School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA 19104, USA","School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026985987","display_name":"Dov Jaron","orcid":"https://orcid.org/0000-0002-2356-6598","observed_orcids":["https://orcid.org/0000-0002-2356-6598"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dov Jaron","raw_affiliation_strings":["School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA 19104, USA","School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":null,"display_name":"Kenneth A. Barbee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth A. Barbee","raw_affiliation_strings":["School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA 19104, USA","School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Market St., Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084190685"],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":null,"fwci":1.1411,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.79351808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"1","first_page":"30","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol-enrichment","display_name":"cholesterol enrichment","score":0.9179999828338623},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8119999766349792},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.8050000071525574},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9179999828338623},{"id":"https://openalex.org/keywords/enos-phosphorylation","display_name":"eNOS phosphorylation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.9449999928474426},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.9750000238418579},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/intracellular-calcium-signaling","display_name":"intracellular calcium signaling","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.8985694646835327},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6420717835426331},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6412169933319092},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.6022292971611023},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5991583466529846},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5873515009880066},{"id":"https://openalex.org/C2908688039","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Nitric Oxide Synthase Type III","level":5,"score":0.5690915584564209},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5333746671676636},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5309877991676331},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4817655086517334},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.47773998975753784},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.47552016377449036},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44808852672576904},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.43563538789749146},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.43279463052749634},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4098644554615021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3371472954750061},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22631892561912537},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14528131484985352}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s12195-016-0456-5","doi":"https://doi.org/10.1007/s12195-016-0456-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12195-016-0456-5","pdf_url":null,"source":{"id":"https://openalex.org/S77874066","display_name":"Cellular and Molecular Bioengineering","issn_l":"1865-5025","issn":["1865-5025","1865-5033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Bioengineering","raw_type":"journal-article"},{"id":"pmid:28138348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28138348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular bioengineering","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5270765","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5270765","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Mol Bioeng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5270765","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5270765","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Mol Bioeng","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4837911295","display_name":"Nitric Oxide (NO) Transport Mechanisms: An Engineering Approach","funder_award_id":"0301446","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5476378105","display_name":"Nitric Oxide Transport Mechanisms: An Engineering approach","funder_award_id":"0730547","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6637741968","display_name":"Multiscale, Transport-Dependent NO Signaling: Cells to Vascular Networks","funder_award_id":"U01HL116256","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6999451230","display_name":null,"funder_award_id":"R01 HL-068164","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000093353","display_name":null,"funder_award_id":"HL068164","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W68733746","https://openalex.org/W1924909341","https://openalex.org/W1966588363","https://openalex.org/W1967411995","https://openalex.org/W1968199949","https://openalex.org/W1986556598","https://openalex.org/W1987178519","https://openalex.org/W1987876724","https://openalex.org/W1996484675","https://openalex.org/W2004804839","https://openalex.org/W2007221278","https://openalex.org/W2013341229","https://openalex.org/W2014969017","https://openalex.org/W2019615565","https://openalex.org/W2020707740","https://openalex.org/W2024221104","https://openalex.org/W2026357078","https://openalex.org/W2031771514","https://openalex.org/W2036205260","https://openalex.org/W2039172968","https://openalex.org/W2044521785","https://openalex.org/W2044995190","https://openalex.org/W2047162542","https://openalex.org/W2056780843","https://openalex.org/W2066374359","https://openalex.org/W2071577234","https://openalex.org/W2077244492","https://openalex.org/W2079740701","https://openalex.org/W2082179247","https://openalex.org/W2104114262","https://openalex.org/W2113937251","https://openalex.org/W2115191848","https://openalex.org/W2117479622","https://openalex.org/W2119870811","https://openalex.org/W2124166947","https://openalex.org/W2130745677","https://openalex.org/W2130870274","https://openalex.org/W2139915912","https://openalex.org/W2142423397","https://openalex.org/W2144188723","https://openalex.org/W2146038402","https://openalex.org/W2149476878","https://openalex.org/W2157989534","https://openalex.org/W2160193184","https://openalex.org/W2161462971","https://openalex.org/W2166468339","https://openalex.org/W2246457688","https://openalex.org/W2317358310","https://openalex.org/W2472201763","https://openalex.org/W6602811142"],"related_works":["https://openalex.org/W2151917957","https://openalex.org/W2274403676","https://openalex.org/W2108271801","https://openalex.org/W2066722683","https://openalex.org/W2171689984","https://openalex.org/W2004175200","https://openalex.org/W4308452875","https://openalex.org/W2297343922","https://openalex.org/W102080802","https://openalex.org/W1966207061"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-07-22T00:00:00"}