{"id":"https://openalex.org/W2467314369","doi":"https://doi.org/10.1093/oxfordjournals.jjco.a039265","title":"Expression of Fragile Site 8q22 in Peripheral Blood Lymphocytes Taken from Patients with Acute Leukemia M2 having t(8;21)(q22;q22)","display_name":"Expression of Fragile Site 8q22 in Peripheral Blood Lymphocytes Taken from Patients with Acute Leukemia M2 having t(8;21)(q22;q22)","publication_year":1989,"publication_date":"1989-03-01","ids":{"openalex":"https://openalex.org/W2467314369","doi":"https://doi.org/10.1093/oxfordjournals.jjco.a039265","mag":"2467314369","pmid":"https://pubmed.ncbi.nlm.nih.gov/2493529"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jjco.a039265","doi":"https://doi.org/10.1093/oxfordjournals.jjco.a039265","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jjco.a039265","pdf_url":null,"source":{"id":"https://openalex.org/S149902429","display_name":"Japanese Journal of Clinical Oncology","issn_l":"0368-2811","issn":["0368-2811","1465-3621"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019559336","display_name":"Takashi Furuya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Furuya","raw_affiliation_strings":["Epidemiology Division, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104","Epidemiology Division, National Cancer Center Research Institute, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Division, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"Epidemiology Division, National Cancer Center Research Institute, Tokyo","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108636624","display_name":"Hisako Ochi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087348","display_name":"National Cancer Centre Japan","ror":"https://ror.org/0025ww868","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisako Ochi","raw_affiliation_strings":["Epidemiology Division, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Division, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104","institution_ids":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110403018","display_name":"Shaw Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087348","display_name":"National Cancer Centre Japan","ror":"https://ror.org/0025ww868","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shaw Watanabe","raw_affiliation_strings":["Epidemiology Division, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Division, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104","institution_ids":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110403018"],"corresponding_institution_ids":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"],"apc_list":{"value":3604,"currency":"USD","value_usd":3604},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.38844234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"19","issue":"1","first_page":"23","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.15369999408721924,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/common-fragile-sites","display_name":"common fragile sites","score":0.8199999928474426},{"id":"https://openalex.org/keywords/chromosome-8","display_name":"chromosome 8","score":0.6819999814033508},{"id":"https://openalex.org/keywords/human-chromosome-21","display_name":"chromosome 21","score":0.8629999756813049},{"id":"https://openalex.org/keywords/21-q22","display_name":"21)(q22","score":0.9629999995231628},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8730000257492065},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.8610000014305115},{"id":"https://openalex.org/keywords/chromosome-breakpoints","display_name":"chromosomal breakpoints","score":0.921999990940094},{"id":"https://openalex.org/keywords/leukemia-predisposition","display_name":"leukemia predisposition","score":0.6930000185966492},{"id":"https://openalex.org/keywords/chromosome-fragility","display_name":"chromosome fragility","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C60449816","wikidata":"https://www.wikidata.org/wiki/Q5113903","display_name":"Chromosomal fragile site","level":4,"score":0.8273800611495972},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7569684982299805},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.6998491287231445},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.6947241425514221},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6705503463745117},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6494309902191162},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.5413427948951721},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4543151557445526},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.44402509927749634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.396180659532547},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3588143587112427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17591241002082825},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16959232091903687},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07484886050224304}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002871","descriptor_name":"Chromosome Banding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002873","descriptor_name":"Chromosome Fragility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002891","descriptor_name":"Chromosomes, Human, Pair 21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002898","descriptor_name":"Chromosomes, Human, Pair 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016590","descriptor_name":"Aphidicolin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043283","descriptor_name":"Chromosome Fragile Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/oxfordjournals.jjco.a039265","doi":"https://doi.org/10.1093/oxfordjournals.jjco.a039265","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jjco.a039265","pdf_url":null,"source":{"id":"https://openalex.org/S149902429","display_name":"Japanese Journal of Clinical Oncology","issn_l":"0368-2811","issn":["0368-2811","1465-3621"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:2493529","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2493529","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of clinical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066333684","https://openalex.org/W2082112437","https://openalex.org/W2052507379","https://openalex.org/W2118916876","https://openalex.org/W236046984","https://openalex.org/W2074203502","https://openalex.org/W1984590980","https://openalex.org/W2410271149","https://openalex.org/W2417000029","https://openalex.org/W2065529064"],"abstract_inverted_index":{"The":[0],"relation":[1],"between":[2],"the":[3,16,25,28,92,110,124,129,146],"expression":[4],"of":[5,32,74,94,160],"common":[6],"fragile":[7],"sites":[8],"and":[9,30,38,79,100,107,114,127,136],"chromosomal":[10,58,95],"breakpoints":[11],"in":[12,15,40],"neoplastic":[13],"cells":[14],"same":[17],"patients":[18,48,70,89,122],"has":[19],"not":[20],"been":[21],"well":[22],"studied.":[23,85],"In":[24,86],"present":[26],"study,":[27],"frequency":[29],"distribution":[31],"aphidicolin-induced":[33],"breaks":[34,96],"on":[35,148],"chromosomes":[36],"8":[37],"21":[39],"peripheral":[41],"blood":[42],"lymphocytes":[43],"(PBL)":[44],"taken":[45],"from":[46,88],"three":[47],"with":[49,71,90,123],"acute":[50,75],"myeloid":[51],"leukemia,":[52],"French-American-British":[53],"classification":[54],"type":[55,159],"M2,":[56],"having":[57],"translocation":[59],"t(8;21)(q22;q22)":[60],"(M2t)":[61],"were":[62,83,97],"studied":[63],"prior":[64],"to":[65,153,156],"any":[66],"initial":[67],"treatment.":[68],"Seven":[69],"other":[72,125],"types":[73],"leukemia":[76],"without":[77],"t(8;21)":[78],"13":[80],"healthy":[81,130],"people":[82],"also":[84],"PBL":[87],"M2t,":[91],"numbers":[93],"1,":[98],"7":[99],"3/216":[101],"metaphasees":[102],"at":[103,112],"bands":[104],"8q21,":[105],"8q22":[106,113],"8q24,":[108],"respectively;":[109],"frequencies":[111],"8q24":[115],"being":[116],"significantly":[117],"higher":[118],"than":[119,134,139],"those":[120],"for":[121,128],"leukemias":[126],"subjects":[131],"(p":[132],"less":[133,138],"0.001":[135],"p":[137],"0.01,":[140],"respectively).":[141],"These":[142],"results":[143],"suggest":[144],"that":[145],"fragility":[147],"chromosome":[149],"8q21-24":[150],"is":[151],"related":[152],"a":[154],"predisposition":[155],"this":[157],"particular":[158],"leukemia.":[161]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}