{"id":"https://openalex.org/W2467303620","doi":"https://doi.org/10.1152/jappl.1978.45.4.521","title":"Cardiovascular effects of whole-body heating in spontaneously hypertensive rats","display_name":"Cardiovascular effects of whole-body heating in spontaneously hypertensive rats","publication_year":1978,"publication_date":"1978-10-01","ids":{"openalex":"https://openalex.org/W2467303620","doi":"https://doi.org/10.1152/jappl.1978.45.4.521","mag":"2467303620","pmid":"https://pubmed.ncbi.nlm.nih.gov/711567"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1978.45.4.521","doi":"https://doi.org/10.1152/jappl.1978.45.4.521","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1978.45.4.521","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"G. Wright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Wright","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110180041","display_name":"Edwin A. Knecht","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Knecht","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046716366","display_name":"Mark A. Toraason","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Toraason","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5076,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.84240105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"4","first_page":"521","last_page":"527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/whole-body-heating","display_name":"whole-body heating","score":0.9829999804496765},{"id":"https://openalex.org/keywords/heat-intolerance","display_name":"heat intolerance","score":0.5899999737739563},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.824999988079071},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cardiovascular-response","display_name":"cardiovascular response","score":0.6359999775886536},{"id":"https://openalex.org/keywords/arterial-blood-pressure","display_name":"arterial blood pressure","score":0.7260000109672546},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.9259999990463257},{"id":"https://openalex.org/keywords/venodilation","display_name":"venodilation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/venous-pooling","display_name":"venous pooling","score":0.9670000076293945},{"id":"https://openalex.org/keywords/venous-return","display_name":"venous return","score":0.9139999747276306},{"id":"https://openalex.org/keywords/thermoregulation","display_name":"thermoregulation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C100564792","wikidata":"https://www.wikidata.org/wiki/Q190259","display_name":"Thermoregulation","level":2,"score":0.7638607025146484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.724113404750824},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6998375058174133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6187093257904053},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5713714361190796},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.5053344368934631},{"id":"https://openalex.org/C30646810","wikidata":"https://www.wikidata.org/wiki/Q185648","display_name":"Torr","level":2,"score":0.4299299716949463},{"id":"https://openalex.org/C47323905","wikidata":"https://www.wikidata.org/wiki/Q3506185","display_name":"Venous return curve","level":3,"score":0.42961233854293823},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.4180837869644165},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3597005605697632},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.3346845507621765},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1978.45.4.521","doi":"https://doi.org/10.1152/jappl.1978.45.4.521","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1978.45.4.521","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:711567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/711567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology: respiratory, environmental and exercise physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409494827","https://openalex.org/W2465528927","https://openalex.org/W2276365233","https://openalex.org/W2270053606","https://openalex.org/W2888277558","https://openalex.org/W397306387","https://openalex.org/W1817434254","https://openalex.org/W2208803537","https://openalex.org/W2170439960","https://openalex.org/W4211258642"],"abstract_inverted_index":{"The":[0,99],"cardiovascular":[1,154],"response":[2,103,122],"to":[3,32,63,73,104,148],"severe":[4,57],"whole-body":[5,149],"heating":[6,150],"was":[7,60,71,82,116],"examined":[8],"in":[9,37,41,68,156,171],"anesthetized":[10],"spontaneously":[11],"hypertensive":[12,146,157],"(SH)":[13],"(mean":[14,23,44],"BP":[15,24],"=":[16,25,47,51],"140":[17],"Torr)":[18,53],"and":[19,95,123,145,168],"normotensive":[20,144],"(N)":[21],"rats":[22,147,158],"96":[26],"Torr).":[27],"Elevation":[28],"of":[29,78,87,119,128,143,165],"colonic":[30],"temperature":[31],"44":[33],"degrees":[34],"C":[35],"resulted":[36],"an":[38,152],"initial":[39],"increase":[40],"arterial":[42,100],"pressure":[43,70,102],"BP:":[45],"SH":[46],"199":[48],"Torr,":[49],"N":[50],"124":[52],"with":[54],"a":[55,74,88,117,125],"subsequent":[56],"hypotension.":[58],"There":[59,136],"little":[61],"evidence":[62],"suggest":[64],"that":[65,114,159],"this":[66],"collapse":[67],"systemic":[69],"related":[72],"direct":[75],"heat":[76,129,169],"impairment":[77],"cardiac":[79],"function.":[80],"It":[81],"more":[83],"likely":[84],"the":[85,120,131,141],"result":[86],"progressive":[89],"venodilation":[90],"which":[91],"produced":[92],"venous":[93,97],"pooling":[94],"decreased":[96,108],"return.":[98],"blood":[101],"exogenous":[105],"catecholamine":[106],"challenge":[107],"at":[109,130],"elevated":[110],"temperatures.":[111],"This":[112],"suggests":[113],"there":[115],"deterioration":[118],"vasoconstrictor":[121],"indicated":[124],"possible":[126],"effect":[127],"receptor":[132],"or":[133],"effector":[134],"level.":[135],"were":[137],"significant":[138],"differences":[139],"between":[140],"responses":[142],"suggesting":[151],"enhanced":[153],"sensitivity":[155],"may":[160],"partially":[161],"explain":[162],"earlier":[163],"reports":[164],"inferior":[166],"thermoregulation":[167],"intolerance":[170],"these":[172],"animals.":[173]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}