{"id":"https://openalex.org/W2467286018","doi":"https://doi.org/10.1248/cpb.c16-00302","title":"Novel 3,4,7-Substituted Benzofuran Derivatives Having Binding Affinity to \u03ba-Opioid Receptor","display_name":"Novel 3,4,7-Substituted Benzofuran Derivatives Having Binding Affinity to \u03ba-Opioid Receptor","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2467286018","doi":"https://doi.org/10.1248/cpb.c16-00302","mag":"2467286018","pmid":"https://pubmed.ncbi.nlm.nih.gov/27373662"},"language":"en","primary_location":{"id":"doi:10.1248/cpb.c16-00302","doi":"https://doi.org/10.1248/cpb.c16-00302","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.c16-00302","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/64/7/64_c16-00302/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CHEMICAL & PHARMACEUTICAL BULLETIN","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/cpb/64/7/64_c16-00302/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Daisuke Nishiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Nishiyama","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kyoto University","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087876395","display_name":"Yuki Sakai","orcid":"https://orcid.org/0000-0003-4874-7755","observed_orcids":["https://orcid.org/0000-0003-4874-7755","https://orcid.org/0000-0003-2475-8548","https://orcid.org/0009-0006-3627-286X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Sakai","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kyoto University","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017664167","display_name":"Haruka Sekiguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruka Sekiguchi","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kyoto University","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113038843","display_name":"Hiroaki Chiba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Chiba","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kyoto University","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031406417","display_name":"Ryosuke Misu","orcid":"https://orcid.org/0009-0004-2019-353X","observed_orcids":["https://orcid.org/0009-0004-2019-353X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke Misu","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kyoto University","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033128839","display_name":"Shinya Oishi","orcid":"https://orcid.org/0000-0002-2833-2539","observed_orcids":["https://orcid.org/0000-0002-2833-2539"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Oishi","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kyoto University","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101847565","display_name":"Nobutaka Fujii","orcid":"https://orcid.org/0000-0002-2666-0643","observed_orcids":["https://orcid.org/0000-0002-2666-0643"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobutaka Fujii","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kyoto University","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013135912","display_name":"Hiroaki Ohno","orcid":"https://orcid.org/0000-0002-3246-4809","observed_orcids":["https://orcid.org/0000-0002-3246-4809"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Ohno","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kyoto University","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":null,"apc_paid":null,"fwci":0.1196,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.40805024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"64","issue":"7","first_page":"996","last_page":"1003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.5781000256538391,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.5781000256538391,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.225600004196167,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13876","display_name":"Chemical synthesis and pharmacological studies","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzofuran-derivatives","display_name":"benzofuran derivatives","score":0.8899999856948853},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9750000238418579},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/aryl-ethers","display_name":"aryl ethers","score":0.8730000257492065},{"id":"https://openalex.org/keywords/opioid-receptor-ligands","display_name":"opioid receptor ligands","score":0.7860000133514404},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9436970353126526},{"id":"https://openalex.org/C2776589655","wikidata":"https://www.wikidata.org/wiki/Q410089","display_name":"Benzofuran","level":2,"score":0.9416820406913757},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5842310786247253},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.5505582690238953},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5021498203277588},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.4869147539138794},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.4624045491218567},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3343803584575653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22059711813926697},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17105403542518616},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/cpb.c16-00302","doi":"https://doi.org/10.1248/cpb.c16-00302","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.c16-00302","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/64/7/64_c16-00302/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CHEMICAL & PHARMACEUTICAL BULLETIN","raw_type":"journal-article"},{"id":"pmid:27373662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27373662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/cpb.c16-00302","doi":"https://doi.org/10.1248/cpb.c16-00302","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.c16-00302","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/64/7/64_c16-00302/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CHEMICAL & PHARMACEUTICAL BULLETIN","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3031026573","display_name":"Development of Novel Drug Discovery Technologies for Target Proteins with Elusive Molecular Basis","funder_award_id":"15H04654","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3706880107","display_name":"Precise activation based on transition state control using neighboring effect and its medicinal application","funder_award_id":"15KT0061","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7573927872","display_name":"Innovative Molecular Transformations Based on Consecutive pai-Activation and Their Medicinal Applications","funder_award_id":"24689001","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322266","display_name":"Ministry of Agriculture, Forestry and Fisheries","ror":"https://ror.org/02zdz1m23"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2467286018.pdf","grobid_xml":"https://content.openalex.org/works/W2467286018.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1789439462","https://openalex.org/W1794170884","https://openalex.org/W1852747819","https://openalex.org/W1900414416","https://openalex.org/W1952914260","https://openalex.org/W2003048898","https://openalex.org/W2010051841","https://openalex.org/W2010531200","https://openalex.org/W2014110722","https://openalex.org/W2020625703","https://openalex.org/W2034700992","https://openalex.org/W2063081431","https://openalex.org/W2065716899","https://openalex.org/W2104538950","https://openalex.org/W2153157543","https://openalex.org/W2325883349","https://openalex.org/W2952498076"],"related_works":["https://openalex.org/W2002102367","https://openalex.org/W2016557265","https://openalex.org/W2037498062","https://openalex.org/W1988729605","https://openalex.org/W2015776855","https://openalex.org/W2952272667","https://openalex.org/W3190119956","https://openalex.org/W3021436392","https://openalex.org/W1965440990","https://openalex.org/W4412154831"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2],"novel":[3],"3,4,7-trisubstituted":[4],"benzofuran":[5],"derivatives":[6],"were":[7,20],"synthesized,":[8],"and":[9,16],"their":[10],"binding":[11,27,34],"affinity":[12],"to":[13,29,35],"\u03ba-":[14],"(KOR)":[15],"\u03bc-opioid":[17],"receptors":[18],"(MOR)":[19],"evaluated.":[21],"Several":[22],"aryl":[23],"ethers":[24],"showed":[25],"moderate":[26],"activities":[28],"KOR":[30],"(IC50=3.9-11":[31],"\u00b5M)":[32],"without":[33],"MOR.":[36]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-07-22T00:00:00"}