{"id":"https://openalex.org/W2467208895","doi":"https://doi.org/10.20546/ijcmas.2016.507.055","title":"Characterization of Micro RNA Signature in Peripheral Blood of Schizophrenia Patients using \u00b5ParafloTM miRNA Microarray Assay","display_name":"Characterization of Micro RNA Signature in Peripheral Blood of Schizophrenia Patients using \u00b5ParafloTM miRNA Microarray Assay","publication_year":2016,"publication_date":"2016-07-10","ids":{"openalex":"https://openalex.org/W2467208895","doi":"https://doi.org/10.20546/ijcmas.2016.507.055","mag":"2467208895"},"language":"en","primary_location":{"id":"doi:10.20546/ijcmas.2016.507.055","doi":"https://doi.org/10.20546/ijcmas.2016.507.055","is_oa":true,"landing_page_url":"https://doi.org/10.20546/ijcmas.2016.507.055","pdf_url":"https://www.ijcmas.com/5-7-2016/Tihomir I. Vachev, et al.pdf","source":{"id":"https://openalex.org/S2765017008","display_name":"International Journal of Current Microbiology and Applied Sciences","issn_l":"2319-7692","issn":["2319-7692","2319-7706"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322614448","host_organization_name":"Excellent Publishers","host_organization_lineage":["https://openalex.org/P4322614448"],"host_organization_lineage_names":["Excellent Publishers"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Current Microbiology and Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ijcmas.com/5-7-2016/Tihomir I. Vachev, et al.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052378958","display_name":"Tihomir Iliev Vachev","orcid":"https://orcid.org/0000-0002-9003-5834","observed_orcids":["https://orcid.org/0000-0002-9003-5834"]},"institutions":[{"id":"https://openalex.org/I192878625","display_name":"Plovdiv University","ror":"https://ror.org/0545p3742","country_code":"BG","type":"education","lineage":["https://openalex.org/I192878625"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Tihomir I. Vachev","raw_affiliation_strings":["Department of Plant Phisyology and Molecular Biology, University of Plovdiv \"Paisii Hilendarski\", 24 Tzar Assen Str., Plovdiv, Bulgaria","University Hospital \"St. George\" Plovdiv, 66 Peshtersko Shuse Str., Plovdiv 4000, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Phisyology and Molecular Biology, University of Plovdiv \"Paisii Hilendarski\", 24 Tzar Assen Str., Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I192878625"]},{"raw_affiliation_string":"University Hospital \"St. George\" Plovdiv, 66 Peshtersko Shuse Str., Plovdiv 4000, Bulgaria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108788285","display_name":"Nikolay Todorov Popov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikolay T. Popov","raw_affiliation_strings":["Psychiatric ward for active treatment of men, State Phsychiatry Hospital Pazardzhik, 28 Bolnichna Str. 4400 Pazardzhik, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric ward for active treatment of men, State Phsychiatry Hospital Pazardzhik, 28 Bolnichna Str. 4400 Pazardzhik, Bulgaria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010713807","display_name":"Danail Marchev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192878625","display_name":"Plovdiv University","ror":"https://ror.org/0545p3742","country_code":"BG","type":"education","lineage":["https://openalex.org/I192878625"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Danail Marchev","raw_affiliation_strings":["Department of Plant Phisyology and Molecular Biology, University of Plovdiv \"Paisii Hilendarski\", 24 Tzar Assen Str., Plovdiv, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Phisyology and Molecular Biology, University of Plovdiv \"Paisii Hilendarski\", 24 Tzar Assen Str., Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I192878625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064661493","display_name":"Hristo Yordanov Ivanov","orcid":"https://orcid.org/0000-0002-7912-3673","observed_orcids":["https://orcid.org/0000-0002-7912-3673"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Hristo Ivanov","raw_affiliation_strings":["Department of Pediatrics and Medical Genetics, Medical University, Plovdiv Vasil Aprilov 15-A Str., Plovdiv 4002, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Medical Genetics, Medical University, Plovdiv Vasil Aprilov 15-A Str., Plovdiv 4002, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054190114","display_name":"Vili Krasteva Stoyanova","orcid":"https://orcid.org/0000-0002-6758-7964","observed_orcids":["https://orcid.org/0000-0002-6758-7964"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Vili K. Stoyanova","raw_affiliation_strings":["Department of Pediatrics and Medical Genetics, Medical University, Plovdiv Vasil Aprilov 15-A Str., Plovdiv 4002, Bulgaria","University Hospital \"St. George\" Plovdiv, 66 Peshtersko Shuse Str., Plovdiv 4000, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Medical Genetics, Medical University, Plovdiv Vasil Aprilov 15-A Str., Plovdiv 4002, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]},{"raw_affiliation_string":"University Hospital \"St. George\" Plovdiv, 66 Peshtersko Shuse Str., Plovdiv 4000, Bulgaria","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052378958"],"corresponding_institution_ids":["https://openalex.org/I192878625"],"apc_list":null,"apc_paid":null,"fwci":0.119,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.51259372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"7","first_page":"503","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5985999703407288,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5985999703407288,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.3806000053882599,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7850000262260437},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mirna-microarray","display_name":"miRNA microarray","score":0.7099999785423279},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8040000200271606},{"id":"https://openalex.org/keywords/differentially-expressed-mirnas","display_name":"differentially expressed miRNAs","score":0.7620000243186951},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.8659999966621399},{"id":"https://openalex.org/keywords/3-utr-regulation","display_name":"3' UTR regulation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/schizophrenia-susceptibility-genes","display_name":"schizophrenia risk genes","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8541067838668823},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.7619863748550415},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6584190130233765},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5726861357688904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5536438822746277},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5517781972885132},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46098360419273376},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.4113999605178833},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3724004626274109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2949833273887634},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2131516933441162},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16745144128799438},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06383004784584045}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20546/ijcmas.2016.507.055","doi":"https://doi.org/10.20546/ijcmas.2016.507.055","is_oa":true,"landing_page_url":"https://doi.org/10.20546/ijcmas.2016.507.055","pdf_url":"https://www.ijcmas.com/5-7-2016/Tihomir I. Vachev, et al.pdf","source":{"id":"https://openalex.org/S2765017008","display_name":"International Journal of Current Microbiology and Applied Sciences","issn_l":"2319-7692","issn":["2319-7692","2319-7706"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322614448","host_organization_name":"Excellent Publishers","host_organization_lineage":["https://openalex.org/P4322614448"],"host_organization_lineage_names":["Excellent Publishers"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Current Microbiology and Applied Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.20546/ijcmas.2016.507.055","doi":"https://doi.org/10.20546/ijcmas.2016.507.055","is_oa":true,"landing_page_url":"https://doi.org/10.20546/ijcmas.2016.507.055","pdf_url":"https://www.ijcmas.com/5-7-2016/Tihomir I. Vachev, et al.pdf","source":{"id":"https://openalex.org/S2765017008","display_name":"International Journal of Current Microbiology and Applied Sciences","issn_l":"2319-7692","issn":["2319-7692","2319-7706"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322614448","host_organization_name":"Excellent Publishers","host_organization_lineage":["https://openalex.org/P4322614448"],"host_organization_lineage_names":["Excellent Publishers"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Current Microbiology and Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2467208895.pdf","grobid_xml":"https://content.openalex.org/works/W2467208895.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1985238051","https://openalex.org/W2000804342","https://openalex.org/W2032208151","https://openalex.org/W2032798168","https://openalex.org/W2065980876","https://openalex.org/W2086029165","https://openalex.org/W2162674813","https://openalex.org/W2171520215"],"related_works":["https://openalex.org/W2065980876","https://openalex.org/W4232535943","https://openalex.org/W7095642511","https://openalex.org/W2476020763","https://openalex.org/W2753642832","https://openalex.org/W2066259757","https://openalex.org/W2795425774","https://openalex.org/W2127960336","https://openalex.org/W2056099994","https://openalex.org/W7118109941"],"abstract_inverted_index":{"Development":[0],"of":[1,15,62,77,104,117,135,148],"biomarkers":[2,57],"for":[3,58,128,133],"psychiatric":[4],"disease":[5],"still":[6],"remains":[7],"challenging.":[8],"Recently,":[9],"numerous":[10],"alterations":[11],"in":[12,18,89,145],"the":[13,75,115,136,146],"expression":[14,88],"microRNAs":[16,118],"(miRNAs)":[17],"peripheral":[19],"blood,":[20],"serum":[21],"and":[22,108,114],"post-mortem":[23],"brain":[24],"tissue":[25],"have":[26],"been":[27],"linked":[28],"to":[29,45,81],"schizophrenia.":[30],"Additionally,":[31],"it":[32],"is":[33],"known":[34],"that":[35,140],"miRNAs":[36,50,139],"can":[37],"inactivate":[38],"a":[39,143],"target":[40,131],"mRNA":[41],"sequence":[42],"through":[43],"binding":[44],"its":[46],"3\u2019UTR":[47],"region.":[48],"Thus,":[49],"might":[51,141],"not":[52],"only":[53],"serve":[54],"as":[55],"prognostic":[56],"diagnosis":[59],"or":[60],"prognosis":[61],"pathological":[63],"conditions":[64],"like":[65],"schizophrenia,":[66],"but":[67],"could":[68],"also":[69],"actively":[70],"modulate":[71],"gene":[72],"function.":[73],"Therefore,":[74],"aim":[76],"this":[78],"study":[79],"was":[80,119],"test":[82],"whether":[83],"specific":[84],"miRNA":[85,98,122],"display":[86],"differential":[87],"patients":[90,107],"with":[91],"schizophrenia":[92,149],"vs.":[93],"healthy":[94,110],"controls":[95,111],"by":[96],"using":[97,121],"microarray":[99,123],"assay.":[100,124],"Venous":[101],"blood":[102],"samples":[103],"33":[105],"affected":[106],"25":[109],"were":[112],"collected":[113],"quantification":[116],"established":[120],"Moreover,":[125],"we":[126],"searched":[127],"potential":[129],"validated":[130],"genes":[132],"each":[134],"differentially":[137],"expressed":[138],"play":[142],"role":[144],"regulation":[147],"susceptibility":[150],"genes.":[151]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-07-22T00:00:00"}