{"id":"https://openalex.org/W2467191356","doi":null,"title":"CXCR4 silencing inhibits invasion and migration of human laryngeal cancer Hep-2 cells.","display_name":"CXCR4 silencing inhibits invasion and migration of human laryngeal cancer Hep-2 cells.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2467191356","mag":"2467191356","pmid":"https://pubmed.ncbi.nlm.nih.gov/26261502","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525836"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3508554","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525836","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525836","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084483764","display_name":"Juntao Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juntao Niu","raw_affiliation_strings":["Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin 300060, China ; Department of Otorhinolaryngology, The Second Hospital of Tianjing Medical University Tianjin 300211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin 300060, China ; Department of Otorhinolaryngology, The Second Hospital of Tianjing Medical University Tianjin 300211, China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I4210133270","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112128299","display_name":"Yongwang Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongwang Huang","raw_affiliation_strings":["Department of Otorhinolaryngology, The Second Hospital of Tianjing Medical University Tianjin 300211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, The Second Hospital of Tianjing Medical University Tianjin 300211, China","institution_ids":["https://openalex.org/I4210133270"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100661413","display_name":"Lun Zhang","orcid":"https://orcid.org/0000-0002-3945-9463","observed_orcids":["https://orcid.org/0000-0002-3945-9463"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lun Zhang","raw_affiliation_strings":["Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin 300060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin 300060, China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1978,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81304158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"6","first_page":"6255","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hep-2-cells","display_name":"HEp-2 cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9850000143051147},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.7329999804496765},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9440000057220459},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9300000071525574},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.968999981880188},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.9350000023841858},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.7477332353591919},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6978973150253296},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6784238815307617},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.661568284034729},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.6371946334838867},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6302974224090576},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5747861266136169},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5662717223167419},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5569456219673157},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5149844288825989},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.48179692029953003},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4506693482398987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4449896216392517},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4231281280517578},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3921133577823639},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3812702000141144},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30375179648399353},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2133435606956482},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19344165921211243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05716100335121155},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.042035073041915894},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3508554","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525836","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4525836","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525836","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:26261502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26261502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:2467191356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26261502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3508554","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525836","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1510540239","https://openalex.org/W1511246213","https://openalex.org/W1535136055","https://openalex.org/W1967798507","https://openalex.org/W1970338125","https://openalex.org/W1972945811","https://openalex.org/W1976233203","https://openalex.org/W1982343380","https://openalex.org/W2000702080","https://openalex.org/W2031925183","https://openalex.org/W2040674457","https://openalex.org/W2053911435","https://openalex.org/W2055700498","https://openalex.org/W2128532174","https://openalex.org/W2140348032","https://openalex.org/W2141978016","https://openalex.org/W2153787979","https://openalex.org/W2155299920","https://openalex.org/W2164591434","https://openalex.org/W2164633129","https://openalex.org/W2170586303","https://openalex.org/W2463083196"],"related_works":["https://openalex.org/W2390090600","https://openalex.org/W2382953496","https://openalex.org/W3030865862","https://openalex.org/W2031925183","https://openalex.org/W2011502917","https://openalex.org/W2317281638","https://openalex.org/W2383706425","https://openalex.org/W2052359587","https://openalex.org/W2078664974","https://openalex.org/W2470369062"],"abstract_inverted_index":{"CXCR4":[0,22,38,41,54,95,115,122,156,188],"has":[1],"been":[2],"reported":[3],"in":[4,23,43,114,196],"various":[5],"types":[6],"of":[7,21,50,53,101,127,138,148,155,162,187],"human":[8],"cancer,":[9],"which":[10],"is":[11,26],"associated":[12],"with":[13,111],"cancer":[14,25],"progression":[15],"and":[16,46,58,68,71,79,93,97,106,132,134,141,143,160,166,178],"metastasis.":[17,59],"However,":[18],"the":[19,30,48,69,112,125,135,146,158,185],"investigation":[20],"laryngeal":[24,197],"extremely":[27],"rare.":[28],"In":[29],"present":[31],"study,":[32],"we":[33],"used":[34],"lentivirus-mediated":[35,87],"shRNA":[36,88],"targeting":[37],"to":[39,174],"silenced":[40],"expression":[42],"Hep-2":[44,56,91,102,163],"cells":[45,92],"evaluated":[47],"effect":[49],"long-term":[51],"suppression":[52],"on":[55],"growth":[57,100],"The":[60],"Cell":[61,104],"proliferation":[62],"was":[63],"analyzed":[64,75],"by":[65,170],"MTS":[66],"assay,":[67],"invasion":[70,105,159],"metastasis":[72,161],"potentials":[73],"were":[74,108],"using":[76],"wound":[77],"healing":[78],"transwell":[80],"assays,":[81],"respectively.":[82],"Our":[83],"results":[84,151],"showed":[85],"that":[86,121,153,184],"effectively":[89],"infected":[90],"suppressed":[94],"expression,":[96],"inhibited":[98],"cell":[99],"cells.":[103],"apoptosis":[107],"decreased":[109,145],"concomitantly":[110],"reduction":[113],"protein":[116],"expression.":[117,180],"Further":[118],"analysis":[119],"revealed":[120],"silencing":[123],"caused":[124],"reducion":[126],"CXCR4,":[128],"CXCL12,":[129],"TIMP2,":[130],"VEGF":[131],"MMP9,":[133],"phosphorylation":[136],"levels":[137],"I\u03baB,":[139],"AKT":[140],"MAPK,":[142],"also":[144],"activity":[147],"NF-\u03baB.":[149],"These":[150,181],"suggested":[152],"knockdown":[154],"inhibits":[157],"through":[164],"PI3K/AKT":[165],"MAPK":[167],"signaling":[168],"pathways,":[169],"decreasing":[171],"NF-\u03baB":[172],"activities":[173],"down-regulate":[175],"VEGF,":[176],"TIMP-2":[177],"MMP-9":[179],"data":[182],"demonstrate":[183],"inhibition":[186],"may":[189],"be":[190],"an":[191],"effective":[192],"interventional":[193],"therapeutic":[194],"strategy":[195],"cancer.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}