{"id":"https://openalex.org/W2467190088","doi":null,"title":"Protective role of the pefloxacin-IFN-gamma association in Leishmania major-infected mice.","display_name":"Protective role of the pefloxacin-IFN-gamma association in Leishmania major-infected mice.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2467190088","mag":"2467190088","pmid":"https://pubmed.ncbi.nlm.nih.gov/8673851"},"language":"en","primary_location":{"id":"pmid:8673851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8673851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The new microbiologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110269120","display_name":"Mario Zucca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Zucca","raw_affiliation_strings":["Institute of Microbiology, University of Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, University of Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031222190","display_name":"Michele Millesimo","orcid":"https://orcid.org/0000-0002-7903-4873","observed_orcids":["https://orcid.org/0000-0002-7903-4873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Millesimo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090467586","display_name":"Mirella Giovarelli","orcid":"https://orcid.org/0000-0002-7397-3466","observed_orcids":["https://orcid.org/0000-0002-7397-3466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Giovarelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014873864","display_name":"Daniela Diverio","orcid":"https://orcid.org/0000-0003-0494-7165","observed_orcids":["https://orcid.org/0000-0003-0494-7165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Diverio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034020241","display_name":"Tiziana Musso","orcid":"https://orcid.org/0000-0002-7487-6078","observed_orcids":["https://orcid.org/0000-0002-7487-6078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Musso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086261022","display_name":"Dianella Savoia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Savoia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5991,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69007811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"1","first_page":"39","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pefloxacin","display_name":"pefloxacin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/leishmania-major","display_name":"Leishmania major","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cutaneous-leishmaniasis","display_name":"cutaneous leishmaniasis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/drug-combination-therapy","display_name":"drug combination therapy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/antiparasitic-activity","display_name":"antiparasitic activity","score":0.503000020980835},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6309999823570251},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2781166304","wikidata":"https://www.wikidata.org/wiki/Q2601859","display_name":"Pefloxacin","level":5,"score":0.6651886701583862},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6577784419059753},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.628876268863678},{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.5224903225898743},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4866681694984436},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4709259867668152},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.43321019411087036},{"id":"https://openalex.org/C98319499","wikidata":"https://www.wikidata.org/wiki/Q455445","display_name":"Amastigote","level":4,"score":0.42593514919281006},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4191022515296936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.375588595867157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35054904222488403},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32354438304901123},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21239694952964783},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.18547070026397705},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.10138142108917236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07054954767227173},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2778049240","wikidata":"https://www.wikidata.org/wiki/Q411447","display_name":"Ofloxacin","level":4,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014344","descriptor_name":"Trypanocidal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015366","descriptor_name":"Pefloxacin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016773","descriptor_name":"Leishmaniasis, Cutaneous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018320","descriptor_name":"Leishmania major","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8673851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8673851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The new microbiologica","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/33258","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/33258","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2467190088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8673851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083474917","https://openalex.org/W2081798138","https://openalex.org/W7042657386","https://openalex.org/W2471253452","https://openalex.org/W2122158599","https://openalex.org/W1976871252","https://openalex.org/W2165204489","https://openalex.org/W2053708558","https://openalex.org/W2119272968","https://openalex.org/W2418156774"],"abstract_inverted_index":{"Four":[0],"groups":[1],"of":[2,16,33,39,51,56,88,105,120,125],"female":[3],"Balb/c":[4],"mice":[5],"were":[6],"inoculated":[7],"in":[8,77,98,101,109,134],"the":[9,48,68,71,86,103,113,118,123,141],"left":[10],"hind":[11],"footpad":[12],"with":[13,30,47,67],"30":[14],"microliters":[15,32],"RPMI":[17,34],"1640":[18,35],"medium":[19,52,76],"containing":[20,36,53],"10(7)":[21],"Leishmania":[22],"major":[23],"amastigotes/ml.":[24],"One":[25],"group":[26,46,64,73],"was":[27,65,94],"injected":[28],"sc":[29],"200":[31],"180":[37],"micrograms":[38],"pefloxacin":[40,121],"for":[41],"20":[42],"days,":[43],"a":[44],"second":[45],"same":[49],"amount":[50],"100":[54],"units":[55],"recombinant":[57],"murine":[58],"interferon":[59],"gamma":[60],"(rmIFN-gamma).":[61],"The":[62],"third":[63],"treated":[66],"association,":[69],"while":[70,91],"fourth":[72],"received":[74],"plain":[75],"an":[78],"identical":[79],"regimen.":[80],"Pefloxacin":[81],"or":[82,144],"IFN-gamma":[83,145],"significantly":[84,95],"decreased":[85],"size":[87],"primary":[89],"lesions,":[90,107],"their":[92],"association":[93],"more":[96],"efficient":[97],"this":[99],"respect,":[100],"reducing":[102],"incidence":[104],"metastatic":[106],"and":[108],"clearing":[110],"parasites":[111],"from":[112],"spleen.":[114],"We":[115],"also":[116],"investigated":[117],"effect":[119],"on":[122,140],"activation":[124],"mouse":[126],"spleen":[127],"cells":[128],"by":[129],"Concanavalin":[130],"A":[131],"(Con":[132],"A)":[133],"vitro,":[135],"without":[136],"detecting":[137],"any":[138],"interference":[139],"proliferative":[142],"response":[143],"production.":[146]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
