{"id":"https://openalex.org/W2467183266","doi":null,"title":"Experimental infection of the woodchuck (Marmota monax monax) with woodchuck hepatitis virus.","display_name":"Experimental infection of the woodchuck (Marmota monax monax) with woodchuck hepatitis virus.","publication_year":1986,"publication_date":"1986-07-01","ids":{"openalex":"https://openalex.org/W2467183266","mag":"2467183266","pmid":"https://pubmed.ncbi.nlm.nih.gov/3724063"},"language":"en","primary_location":{"id":"pmid:3724063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3724063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055533435","display_name":"GAIL V. TYLER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G V Tyler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090377841","display_name":"Snyder Rl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Snyder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108188026","display_name":"Jesse W. Summers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Summers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5996,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90079782,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"55","issue":"1","first_page":"51","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/woodchuck-hepatitis-virus","display_name":"woodchuck hepatitis virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/marmota-monax","display_name":"Marmota monax","score":0.8880000114440918},{"id":"https://openalex.org/keywords/experimental-infection","display_name":"experimental infection","score":0.9279999732971191},{"id":"https://openalex.org/keywords/acute-hepatitis","display_name":"acute hepatitis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hbcag","display_name":"HBcAg","score":0.4320000112056732},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.7390000224113464},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.7369999885559082},{"id":"https://openalex.org/keywords/hepatocellular-necrosis","display_name":"liver necrosis","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C2781079990","wikidata":"https://www.wikidata.org/wiki/Q8032510","display_name":"Woodchuck hepatitis virus","level":5,"score":0.9677330255508423},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5664502382278442},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5604472160339355},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.5146597027778625},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.494704931974411},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.4911046028137207},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.483646035194397},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.47079434990882874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4687417149543762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.400251567363739},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38257792592048645},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.37721017003059387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37290698289871216},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.32843834161758423},{"id":"https://openalex.org/C2780617729","wikidata":"https://www.wikidata.org/wiki/Q1356878","display_name":"Hepadnaviridae","level":4,"score":0.2875213921070099}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006518","descriptor_name":"Hepatitis Viruses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006524","descriptor_name":"Hepatitis, Viral, Animal","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006524","descriptor_name":"Hepatitis, Viral, Animal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006524","descriptor_name":"Hepatitis, Viral, Animal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008392","descriptor_name":"Marmota","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012589","descriptor_name":"Sciuridae","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3724063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3724063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:2467183266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3724063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1768221818","https://openalex.org/W1814828787","https://openalex.org/W2054192564","https://openalex.org/W2144266248","https://openalex.org/W2425138882","https://openalex.org/W2374920516","https://openalex.org/W110311297","https://openalex.org/W1981884306","https://openalex.org/W1590188654","https://openalex.org/W2041548797"],"abstract_inverted_index":{"Six":[0],"woodchucks,":[1],"10":[2],"1/2":[3],"months":[4],"of":[5,12,21,104,115,129,136,146,162,166,173,233,236],"age,":[6],"injected":[7,26],"intramuscularly":[8],"with":[9,27,119,133,171,198,219],"0.02":[10],"ml":[11],"woodchuck":[13,215,223],"hepatitis":[14,121,209,239],"virus":[15],"(WHV)-positive":[16],"serum":[17,140],"and":[18,24,37,59,80,97,101,117,141,176,180],"two":[19],"woodchucks":[20,93],"similar":[22],"age":[23],"origin":[25],"phosphate":[28],"buffered":[29],"saline":[30],"were":[31,48,169],"studied":[32],"by":[33,76,84,216],"serial":[34],"blood":[35],"samples":[36,47],"liver":[38,73,130],"biopsy":[39,74],"sections":[40,75],"over":[41],"an":[42,227],"18":[43],"week":[44],"period.":[45],"Serum":[46],"assayed":[49],"for":[50,230],"WHV":[51,62,66],"surface":[52],"antigen":[53,64,68],"(WHsAg),":[54],"its":[55],"corresponding":[56],"antibody":[57,60],"(anti-WHs)":[58],"to":[61],"core":[63,67],"(anti-WHc).":[65],"(WHcAg)":[69],"was":[70,82,150],"detected":[71,83,153],"in":[72,112,154,159,194,213,240],"fluorescent":[77],"labeled":[78],"anti-WHc,":[79],"WHsAg":[81,137,157],"the":[85,113,134,139,144,155,160,190,195,214,222,231,234],"Victoria":[86],"blue":[87],"stain.":[88],"All":[89],"six":[90],"experimentally":[91],"infected":[92],"eventually":[94],"developed":[95,99],"anti-WHs":[96],"four":[98,196],"serologic":[100],"histologic":[102,127],"signs":[103,128],"acute":[105,120,199,208,237],"hepatitis.":[106,200],"Hepatic":[107],"lesions":[108,110],"resembled":[109],"described":[111],"livers":[114],"chimpanzees":[116],"humans":[118],"B":[122],"viral":[123,238],"infections.":[124],"The":[125,183,201],"first":[126],"change":[131],"coincided":[132],"appearance":[135],"within":[138,143],"WHcAg":[142,149],"cytoplasm":[145,161],"hepatocytes.":[147,163],"After":[148],"no":[151],"longer":[152],"serum,":[156],"appeared":[158],"Microfocal":[164],"areas":[165],"hepatic":[167],"necrosis":[168],"associated":[170],"aggregates":[172],"lymphocytes,":[174],"macrophages,":[175],"a":[177],"few":[178],"neutrophils":[179],"plasma":[181],"cells.":[182],"periportal":[184],"exudate":[185],"became":[186],"increasingly":[187],"abundant":[188],"during":[189],"18-week":[191],"study":[192,205,232],"period":[193],"animals":[197],"results":[202],"from":[203],"this":[204],"indicate":[206],"that":[207],"may":[210],"be":[211],"induced":[212],"experimental":[217],"infection":[218],"WHV.":[220],"Furthermore,":[221],"might":[224],"serve":[225],"as":[226],"excellent":[228],"model":[229],"pathogenesis":[235],"man.":[241]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
