{"id":"https://openalex.org/W2467166619","doi":null,"title":"Treatment of multiple myeloma with thalidomide, dexamethasone, and zoledronate in an inner-city population with high prevalence of HIV/AIDS","display_name":"Treatment of multiple myeloma with thalidomide, dexamethasone, and zoledronate in an inner-city population with high prevalence of HIV/AIDS","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2467166619","mag":"2467166619"},"language":"en","primary_location":{"id":"mag:2467166619","doi":null,"is_oa":false,"landing_page_url":"https://cebp.aacrjournals.org/content/16/11_Supplement/B80.abstract","pdf_url":null,"source":{"id":"https://openalex.org/S2764672815","display_name":"Cancer Epidemiology and Prevention Biomarkers","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Epidemiology and Prevention Biomarkers","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034898853","display_name":"Uwe Klueppelberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uwe Klueppelberg","raw_affiliation_strings":["SUNY - Downstate Medical Center, Brooklyn, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY - Downstate Medical Center, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091643041","display_name":"Eric L. Smith","orcid":"https://orcid.org/0000-0002-0296-7587","observed_orcids":["https://orcid.org/0000-0002-0296-7587"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L. Smith","raw_affiliation_strings":["SUNY - Downstate Medical Center, Brooklyn, NY"],"raw_orcid":"https://orcid.org/0000-0002-0296-7587","affiliations":[{"raw_affiliation_string":"SUNY - Downstate Medical Center, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011258393","display_name":"Marc Justin Braunstein","orcid":"https://orcid.org/0000-0002-0859-7257","observed_orcids":["https://orcid.org/0000-0002-0859-7257"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Braunstein","raw_affiliation_strings":["SUNY - Downstate Medical Center, Brooklyn, NY"],"raw_orcid":"https://orcid.org/0000-0002-0859-7257","affiliations":[{"raw_affiliation_string":"SUNY - Downstate Medical Center, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043093823","display_name":"Olcay Batuman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olcay Batuman","raw_affiliation_strings":["SUNY - Downstate Medical Center, Brooklyn, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY - Downstate Medical Center, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181697535"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31299582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8949999809265137},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/hiv-aids","display_name":"HIV/AIDS","score":0.7620000243186951},{"id":"https://openalex.org/keywords/newly-diagnosed-multiple-myeloma","display_name":"newly diagnosed multiple myeloma","score":0.8199999928474426},{"id":"https://openalex.org/keywords/low-dose-thalidomide","display_name":"low-dose thalidomide","score":0.8330000042915344},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.6779999732971191},{"id":"https://openalex.org/keywords/osteonecrosis-of-the-jaw","display_name":"osteonecrosis of the jaw","score":0.8230000138282776},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5490000247955322},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.4410000145435333},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.36899998784065247},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8832792043685913},{"id":"https://openalex.org/C2779609412","wikidata":"https://www.wikidata.org/wiki/Q203174","display_name":"Thalidomide","level":3,"score":0.7719312906265259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6377694010734558},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.6178218126296997},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6005095839500427},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5910862684249878},{"id":"https://openalex.org/C191093355","wikidata":"https://www.wikidata.org/wiki/Q9250577","display_name":"Exact test","level":2,"score":0.5739827752113342},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45497819781303406},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4325530230998993},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4316372871398926},{"id":"https://openalex.org/C66339696","wikidata":"https://www.wikidata.org/wiki/Q6089397","display_name":"Log-rank test","level":3,"score":0.41390669345855713},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.37635427713394165},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3696008026599884},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28534573316574097},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2467166619","doi":null,"is_oa":false,"landing_page_url":"https://cebp.aacrjournals.org/content/16/11_Supplement/B80.abstract","pdf_url":null,"source":{"id":"https://openalex.org/S2764672815","display_name":"Cancer Epidemiology and Prevention Biomarkers","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Epidemiology and Prevention Biomarkers","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2552953477","https://openalex.org/W2536858063","https://openalex.org/W2580095565","https://openalex.org/W2582748701","https://openalex.org/W2243209818","https://openalex.org/W2591483844","https://openalex.org/W2416073348","https://openalex.org/W2267500201","https://openalex.org/W2127597989","https://openalex.org/W2331217181"],"abstract_inverted_index":{"B80":[0],"This":[2],"single-arm,":[3],"open-label":[4],"trial":[5],"evaluated":[6],"the":[7,22,154,158,248,258],"efficacy":[8],"and":[9,18,42,46,73,106,148,181,265,276,284],"safety":[10],"of":[11,24,37,116,142,170,177,223,244,247,272,282,291,300],"low-dose":[12],"thalidomide":[13],"in":[14,28,218,242,261,274,302,310],"combination":[15,262],"with":[16,34,44,52,58,162,200,228,263],"dexamethasone":[17,266],"zoledronate":[19,264],"(TDZ)":[20],"for":[21,49,67,83,86,91,165,211],"treatment":[23,271],"multiple":[25],"myeloma":[26],"(MM)":[27],"a":[29,307],"largely":[30],"African-Caribbean":[31],"inner-city":[32],"population":[33],"high":[35,298],"prevalence":[36],"HIV/AIDS.":[38],"TDZ":[39,64,288],"is":[40],"non-myelotoxic":[41],"compatible":[43],"HAART,":[45],"thus":[47],"appropriate":[48],"HIV+":[50,147,277],"patients":[51,57,150,220],"MM.":[53,311],"Methods:":[54],"45":[55,171],"consecutive":[56],"newly":[59],"diagnosed":[60],"MM":[61,273],"were":[62,151,173,182,192,202,225,236],"enrolled.":[63],"was":[65,112,250],"given":[66],"24":[68],"months":[69],"or":[70,132,157],"until":[71],"progression,":[72],"consisted":[74],"of:":[75],"thalidomide,":[76],"100":[77],"mg":[78,82,103,109],"daily;":[79],"dexamethasone,":[80],"10-40":[81],"4":[84,97,102],"days/week":[85],"3":[87],"weeks":[88],"each":[89,99],"month":[90],"6":[92,219],"months,":[93],"then":[94],"reduced":[95],"to":[96],"days":[98],"month;":[100],"zoledronate,":[101],"IV":[104],"monthly;":[105],"ASA,":[107,215],"81":[108],"daily.":[110],"Response":[111],"stratified":[113],"by":[114,153],"reduction":[115],"M":[117],"protein":[118],"levels:":[119],">":[120,127],"75%":[121],"(very":[122],"good":[123],"partial":[124],"response":[125,130,135],"[VPR]),":[126],"50-75%":[128],"(partial":[129],"[PR]),":[131],"25-50%":[133],"(minor":[134],"[MR]).":[136],"Kaplan-Meier":[137],"survival":[138],"analyses":[139],"provided":[140],"estimates":[141],"longitudinal":[143],"survival.":[144,296],"Differences":[145],"between":[146],"HIV-":[149],"assessed":[152],"log-rank":[155],"test":[156],"Fisher":[159],"Exact":[160],"Test":[161],"mid-P":[163],"correction":[164],"small":[166],"samples.":[167],"Results:":[168],"8":[169,196],"enrollees":[172],"HIV":[174,197,201,275,301],"seropositive,":[175],"7":[176],"whom":[178,224],"had":[179],"AIDS":[180],"on":[183],"HAART.":[184],"38":[185],"(27F/11M;":[186],"median":[187],"age":[188],"=":[189],"60.4":[190],"years)":[191],"evaluable,":[193],"including":[194],"all":[195,222],"patients.":[198,278],"Patients":[199],"younger":[203],"(Mann-Whitney":[204],"U":[205],"test,":[206],"P":[207],".2":[210],"both).":[212],"Despite":[213],"prophylactic":[214],"thromboembolism":[216],"occurred":[217,241],"(16%),":[221],"successfully":[226],"treated":[227],"full":[229],"anticoagulation.":[230],"Other":[231],"toxicities":[232],"\u2265":[233],"Grade":[234],"2,":[235],"not":[237,251],"observed.":[238],"Skeletal":[239],"events":[240,286],"8%":[243],"patients;":[245],"osteonecrosis":[246],"jaw":[249],"encountered.":[252],"Conclusion:":[253],"Thalidomide":[254],"administered":[255],"at":[256],"half":[257],"standard":[259],"dose":[260],"provides":[267],"safe,":[268],"efficacious":[269],"long-term":[270],"The":[279,297],"modest":[280],"frequency":[281],"toxicity":[283],"skeletal":[285],"under":[287],"improves":[289],"quality":[290],"life":[292],"as":[293,295],"well":[294],"incidence":[299],"our":[303],"study":[304],"cohort":[305],"suggests":[306],"pathogenetic":[308],"role":[309]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-07-22T00:00:00"}