{"id":"https://openalex.org/W2467130867","doi":"https://doi.org/10.1111/voxs.12282","title":"Two solvent/detergent\u2010treated plasma products with a different biochemical profile","display_name":"Two solvent/detergent\u2010treated plasma products with a different biochemical profile","publication_year":2016,"publication_date":"2016-06-23","ids":{"openalex":"https://openalex.org/W2467130867","doi":"https://doi.org/10.1111/voxs.12282","mag":"2467130867"},"language":"en","primary_location":{"id":"doi:10.1111/voxs.12282","doi":"https://doi.org/10.1111/voxs.12282","is_oa":true,"landing_page_url":"https://doi.org/10.1111/voxs.12282","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/voxs.12282","source":{"id":"https://openalex.org/S92625435","display_name":"ISBT Science Series","issn_l":"1751-2816","issn":["1751-2816","1751-2824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISBT Science Series","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/voxs.12282","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057190372","display_name":"Andrea Neisser\u2010Svae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130982","display_name":"Octapharma (United States)","ror":"https://ror.org/03vfc4p83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210087655","https://openalex.org/I4210130982"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Neisser\u2010Svae","raw_affiliation_strings":["Octapharma USA, Hoboken, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Octapharma USA, Hoboken, NJ, USA","institution_ids":["https://openalex.org/I4210130982"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055812879","display_name":"Andrea Heger","orcid":"https://orcid.org/0000-0001-7722-6049","observed_orcids":["https://orcid.org/0000-0001-7722-6049"]},"institutions":[{"id":"https://openalex.org/I4210111127","display_name":"Octapharma (Austria)","ror":"https://ror.org/022k50n33","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210087655","https://openalex.org/I4210111127"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A. Heger","raw_affiliation_strings":["Octapharma Pharmazeutika Produktionsges.m.b.H, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Octapharma Pharmazeutika Produktionsges.m.b.H, Vienna, Austria","institution_ids":["https://openalex.org/I4210111127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057190372"],"corresponding_institution_ids":["https://openalex.org/I4210130982"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.2303,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53225904,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"11","issue":"2","first_page":"94","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.16779999434947968,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solvent-detergent-treated-plasma","display_name":"solvent/detergent-treated plasma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/coagulation-factors","display_name":"coagulation factors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.8029999732971191},{"id":"https://openalex.org/keywords/von-willebrand-factor-multimers","display_name":"von Willebrand factor multimers","score":0.972000002861023},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.4169999957084656},{"id":"https://openalex.org/keywords/factor-ix","display_name":"factor IX","score":0.8069999814033508},{"id":"https://openalex.org/keywords/factor-xi","display_name":"factor XI","score":0.828000009059906},{"id":"https://openalex.org/keywords/protein-c","display_name":"protein C","score":0.9399999976158142},{"id":"https://openalex.org/keywords/protein-s","display_name":"protein S","score":0.9980000257492065},{"id":"https://openalex.org/keywords/plasmin-inhibitor","display_name":"plasmin inhibitor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ultrafiltration","display_name":"ultrafiltration","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.643683671951294},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.6036630868911743},{"id":"https://openalex.org/C50817676","wikidata":"https://www.wikidata.org/wiki/Q7880534","display_name":"Ultrafiltration (renal)","level":2,"score":0.5215104222297668},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.48658502101898193},{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.4679884612560272},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.41215789318084717},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3297503888607025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3069247305393219},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.2771280109882355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2374434471130371},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21233823895454407},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06713166832923889}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/voxs.12282","doi":"https://doi.org/10.1111/voxs.12282","is_oa":true,"landing_page_url":"https://doi.org/10.1111/voxs.12282","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/voxs.12282","source":{"id":"https://openalex.org/S92625435","display_name":"ISBT Science Series","issn_l":"1751-2816","issn":["1751-2816","1751-2824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISBT Science Series","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1111/voxs.12282","doi":"https://doi.org/10.1111/voxs.12282","is_oa":true,"landing_page_url":"https://doi.org/10.1111/voxs.12282","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/voxs.12282","source":{"id":"https://openalex.org/S92625435","display_name":"ISBT Science Series","issn_l":"1751-2816","issn":["1751-2816","1751-2824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISBT Science Series","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2467130867.pdf","grobid_xml":"https://content.openalex.org/works/W2467130867.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W39129397","https://openalex.org/W168010597","https://openalex.org/W1490436562","https://openalex.org/W1822278626","https://openalex.org/W1876196958","https://openalex.org/W1924159747","https://openalex.org/W1989190812","https://openalex.org/W2023068203","https://openalex.org/W2029496238","https://openalex.org/W2031571437","https://openalex.org/W2037486491","https://openalex.org/W2039098715","https://openalex.org/W2046603339","https://openalex.org/W2058442810","https://openalex.org/W2089200801","https://openalex.org/W2107198289","https://openalex.org/W2110026546","https://openalex.org/W2114315172","https://openalex.org/W2129949749","https://openalex.org/W2141553906","https://openalex.org/W2144044710","https://openalex.org/W2152520723","https://openalex.org/W2153235907","https://openalex.org/W2158771004","https://openalex.org/W2160332454","https://openalex.org/W2164149361"],"related_works":["https://openalex.org/W2154632445","https://openalex.org/W2083239894","https://openalex.org/W2001836156","https://openalex.org/W1876196958","https://openalex.org/W2063136806","https://openalex.org/W2383644643","https://openalex.org/W2059022080","https://openalex.org/W2375165165","https://openalex.org/W2041898921","https://openalex.org/W2414422120"],"abstract_inverted_index":{"Background":[0],"and":[1,18,36,43,45,57,83,100,134,154,160,167],"Objectives":[2],"The":[3,38,209],"distribution":[4],"of":[5,40,118,139,147,218],"US\u2010produced":[6],"solvent/detergent":[7],"(S/D)\u2010treated":[8],"plasma":[9,62,189],"(Plas+SD)":[10],"was":[11,70,124],"discontinued":[12],"in":[13,53,72,88,112,126,198],"2003":[14],"due":[15],"to":[16,78,108,131,214],"bleeding":[17],"thrombotic":[19],"events.":[20],"In":[21,65,115],"this":[22,113],"work,":[23],"we":[24],"were":[25,51,85,104,172],"searching":[26],"for":[27,158,175,204],"explanations":[28],"that":[29,221],"might":[30],"explain":[31],"these":[32,170],"severe":[33],"side\u2010effects.":[34],"Materials":[35],"Methods":[37],"activities":[39],"coagulation":[41,80],"factors":[42,81],"inhibitors":[44],"von":[46],"Willebrand":[47],"factor":[48],"(VWF)":[49],"multimers":[50,123],"tested":[52,150],"three":[54],"Plas+SD":[55,68,90,128,141,225],"batches":[56],"compared":[58,77,130],"with":[59,223],"an":[60],"S/D\u2010treated":[61],"named":[63],"OctaplasLG.":[64],"addition,":[66,116],"the":[67,89,127,140,152,176,180,193,205,219,224],"process":[69,200],"investigated":[71],"downscale":[73],"studies.":[74],"Results":[75],"When":[76],"OctaplasLG,":[79],"(F)V":[82],"FXI":[84],"significantly":[86,105],"increased":[87],"product,":[91],"whereas":[92],"FIX,":[93],"protein":[94,97],"C":[95],"(PC),":[96],"S":[98],"(PS)":[99],"plasmin":[101],"inhibitor":[102],"(PI)":[103],"decreased,":[106],"leading":[107],"a":[109,215],"haemostatic":[110],"imbalance":[111],"product.":[114,226],"loss":[117],"high":[119],"molecular":[120],"weight":[121],"VWF":[122],"observed":[125],"product":[129],"both":[132,187],"OctaplasLG":[133],"normal":[135],"plasma.":[136],"Downscale":[137],"studies":[138],"manufacturing":[142,190],"steps":[143,201],"revealed":[144],"significant":[145],"losses":[146,171],"all":[148],"parameters":[149,178],"during":[151],"S/D\u2010treatment":[153],"removal":[155],"steps.":[156],"Except":[157],"PS":[159],"PI,":[161],"which":[162],"remained":[163],"decreased":[164],"by":[165,179],"47%":[166],"65%,":[168],"respectively,":[169],"nearly":[173],"compensated":[174],"other":[177],"subsequent":[181],"ultrafiltration":[182],"step":[183],"performed.":[184],"Conclusion":[185],"Although":[186],"S/D":[188],"processes":[191],"have":[192],"same":[194],"basic":[195],"set\u2010up,":[196],"differences":[197],"single":[199],"are":[202],"responsible":[203],"different":[206],"biochemical":[207],"profiles.":[208],"study":[210],"performed":[211],"may":[212],"contribute":[213],"better":[216],"understanding":[217],"side\u2010effects":[220],"occurred":[222]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
