{"id":"https://openalex.org/W2467043041","doi":null,"title":"Steroid withdrawal, rejection and the mixed lymphocyte reaction in children after renal transplantation.","display_name":"Steroid withdrawal, rejection and the mixed lymphocyte reaction in children after renal transplantation.","publication_year":1993,"publication_date":"1993-10-01","ids":{"openalex":"https://openalex.org/W2467043041","mag":"2467043041","pmid":"https://pubmed.ncbi.nlm.nih.gov/8246367"},"language":"en","primary_location":{"id":"pmid:8246367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8246367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039281014","display_name":"Elizabeth G. Ingulli","orcid":"https://orcid.org/0000-0003-2591-8945","observed_orcids":["https://orcid.org/0000-0003-2591-8945"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Ingulli","raw_affiliation_strings":["Renal Division, SUNY Children's Health Center at Brooklyn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division, SUNY Children's Health Center at Brooklyn","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108599572","display_name":"Sharma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Sharma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101775001","display_name":"Anup Kumar Singh","orcid":"https://orcid.org/0000-0003-4522-9098","observed_orcids":["https://orcid.org/0000-0003-4522-9098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041388284","display_name":"Manikkam Suthanthiran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Suthanthiran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037453705","display_name":"Amir H. Tejani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Tejani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4881,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.82911392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"43","issue":null,"first_page":"S36","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticosteroid-withdrawal","display_name":"corticosteroid withdrawal","score":0.7730000019073486},{"id":"https://openalex.org/keywords/pediatric-kidney-transplantation","display_name":"pediatric kidney transplantation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.6859999895095825},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.7829999923706055},{"id":"https://openalex.org/keywords/allograft-tolerance","display_name":"allograft tolerance","score":0.800000011920929},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.7879999876022339},{"id":"https://openalex.org/keywords/prednisone-taper","display_name":"prednisone taper","score":0.890999972820282},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.703000009059906},{"id":"https://openalex.org/keywords/long-term-corticosteroid-therapy","display_name":"long-term corticosteroid therapy","score":0.800000011920929},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8004389405250549},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.7245953679084778},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6190078258514404},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5089612007141113},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.4923456907272339},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.47479337453842163},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45736274123191833},{"id":"https://openalex.org/C2778740727","wikidata":"https://www.wikidata.org/wiki/Q12055129","display_name":"Mixed lymphocyte reaction","level":4,"score":0.4213113784790039},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40334099531173706},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3384496569633484},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2722669243812561},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.1275193989276886}],"mesh":[{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011182","descriptor_name":"Postoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8246367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8246367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},{"id":"mag:2467043041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8246367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2408908472","https://openalex.org/W2399459610","https://openalex.org/W2397851505","https://openalex.org/W2017278250","https://openalex.org/W1500996383","https://openalex.org/W1982460719","https://openalex.org/W2158796201","https://openalex.org/W3185472244","https://openalex.org/W2500457136","https://openalex.org/W2120095600"],"abstract_inverted_index":{"With":[0],"improved":[1],"long-term":[2],"graft":[3],"survival":[4],"after":[5,124,139,162],"renal":[6,57],"transplantation,":[7],"cardiovascular":[8,52],"mortality":[9],"is":[10,21,30],"emerging":[11],"as":[12],"the":[13,62,68,106,127,132,142,165,172,225],"leading":[14],"cause":[15,36],"of":[16,37,64,70,90,105,116,126,131,141,154,196,212,227],"death":[17],"in":[18,25,55,72],"adults":[19],"and":[20,40,67,78,98,185],"also":[22],"being":[23],"reported":[24],"children.":[26],"Chronic":[27],"corticosteroid":[28],"therapy":[29],"thought":[31],"to":[32,50,75,95,121,149,159,201,207,217],"be":[33],"an":[34,71,110],"important":[35],"post-transplant":[38],"hyperlipidemia":[39],"hypertension.":[41],"This":[42],"study":[43],"describes":[44],"a":[45,86,114,152],"steroid":[46,128,175,186],"withdrawal":[47],"protocol":[48],"initiated":[49],"reduced":[51],"risk":[53],"factors":[54],"pediatric":[56],"allograft":[58,228],"recipients,":[59],"reports":[60],"on":[61,101],"rate":[63],"rejection":[65,87,112,147],"observed":[66],"use":[69],"vitro":[73],"method":[74],"measure":[76],"immunoresponsiveness":[77],"identify":[79],"those":[80],"patients":[81,92,108,145],"who":[82],"have":[83],"not":[84],"experienced":[85,109],"episode.":[88],"Thirty-six":[89],"67":[91],"were":[93,99,199,215],"able":[94],"discontinue":[96],"prednisone":[97],"maintained":[100],"cyclosporine":[102],"alone.":[103],"Twenty-two":[104],"36":[107,122],"acute":[111],"episode":[113],"mean":[115,153],"14":[117],"months":[118,138,156],"(range":[119,157],"1.5":[120],"months)":[123,161],"completion":[125,140],"taper.":[129,143],"Ten":[130],"22":[133],"rejections":[134],"occurred":[135],"within":[136],"12":[137],"Fourteen":[144],"remain":[146],"free":[148],"date":[150],"for":[151],"70.3":[155],"19":[158],"111":[160],"withdrawal.":[163],"Using":[164],"mixed":[166],"lymphocyte":[167],"culture":[168],"reaction,":[169],"we":[170],"tested":[171],"hypothesis":[173],"that":[174],"dependent":[176],"recipients":[177,188],"(SDR)":[178],"will":[179,190],"express":[180],"donor":[181,192,202,218],"antigen":[182],"specific":[183,203,219],"responsiveness":[184],"independent":[187],"(SIR)":[189],"exhibit":[191],"antigen-specific":[193],"tolerance.":[194,229],"Four":[195],"seven":[197],"SDR":[198],"tolerant":[200],"antigens":[204],"but":[205],"responsive":[206,216],"unrelated":[208],"controls,":[209],"while":[210],"five":[211],"six":[213],"SIR":[214],"antigens.":[220],"These":[221],"unanticipated":[222],"results":[223],"highlight":[224],"complexity":[226]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
