{"id":"https://openalex.org/W2466848815","doi":null,"title":"Exploring variation of mu-opioid receptor gene and subjective opioid effects in healthy men","display_name":"Exploring variation of mu-opioid receptor gene and subjective opioid effects in healthy men","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2466848815","mag":"2466848815"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/40918","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/40918","pdf_url":"http://hdl.handle.net/10852/40918","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/40918","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052457769","display_name":"Hedda Maurud","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hedda Maurud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052457769"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.14509999752044678,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.10270000249147415,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9129999876022339},{"id":"https://openalex.org/keywords/oprm1","display_name":"OPRM1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/a118g-polymorphism","display_name":"A118G polymorphism","score":0.9710000157356262},{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":0.8159999847412109},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.492000013589859},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.4779999852180481},{"id":"https://openalex.org/keywords/lethargy","display_name":"lethargy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/well-being","display_name":"well-being","score":0.8309999704360962},{"id":"https://openalex.org/keywords/healthy-men","display_name":"healthy men","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.7136195302009583},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.6153619289398193},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.46301552653312683},{"id":"https://openalex.org/C14397066","wikidata":"https://www.wikidata.org/wiki/Q14911924","display_name":"\u03bc-opioid receptor","level":4,"score":0.4457045793533325},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4363112449645996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38949689269065857},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35510697960853577},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33721548318862915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2982831597328186},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09635287523269653},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/40918","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/40918","pdf_url":"http://hdl.handle.net/10852/40918","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2466848815","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/handle/10852/40918","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/40918","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/40918","pdf_url":"http://hdl.handle.net/10852/40918","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2466848815.pdf","grobid_xml":"https://content.openalex.org/works/W2466848815.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W16446374","https://openalex.org/W142954314","https://openalex.org/W160294806","https://openalex.org/W192884275","https://openalex.org/W1486023414","https://openalex.org/W1501567039","https://openalex.org/W1518468624","https://openalex.org/W1659527729","https://openalex.org/W1776694187","https://openalex.org/W1818115547","https://openalex.org/W1900414416","https://openalex.org/W1916131873","https://openalex.org/W1967414446","https://openalex.org/W1968161839","https://openalex.org/W1970286686","https://openalex.org/W1978715208","https://openalex.org/W1979385488","https://openalex.org/W1983877031","https://openalex.org/W1985094131","https://openalex.org/W1988182239","https://openalex.org/W1989271036","https://openalex.org/W1993709886","https://openalex.org/W1994458277","https://openalex.org/W1994925343","https://openalex.org/W2011354364","https://openalex.org/W2011653800","https://openalex.org/W2012128092","https://openalex.org/W2012743573","https://openalex.org/W2013796305","https://openalex.org/W2014898651","https://openalex.org/W2016124588","https://openalex.org/W2017974394","https://openalex.org/W2018096782","https://openalex.org/W2020031422","https://openalex.org/W2022649170","https://openalex.org/W2031788594","https://openalex.org/W2034887368","https://openalex.org/W2037831604","https://openalex.org/W2041265673","https://openalex.org/W2064879620","https://openalex.org/W2065775206","https://openalex.org/W2070088299","https://openalex.org/W2072483237","https://openalex.org/W2074406420","https://openalex.org/W2078307955","https://openalex.org/W2080660424","https://openalex.org/W2082558994","https://openalex.org/W2083545276","https://openalex.org/W2084744712","https://openalex.org/W2088730086","https://openalex.org/W2090501717","https://openalex.org/W2092124601","https://openalex.org/W2093433706","https://openalex.org/W2094347820","https://openalex.org/W2112755003","https://openalex.org/W2114207481","https://openalex.org/W2115650553","https://openalex.org/W2119581183","https://openalex.org/W2121429100","https://openalex.org/W2121923873","https://openalex.org/W2123390254","https://openalex.org/W2128443527","https://openalex.org/W2130690736","https://openalex.org/W2130762071","https://openalex.org/W2133555277","https://openalex.org/W2135432300","https://openalex.org/W2140341041","https://openalex.org/W2145773157","https://openalex.org/W2145849285","https://openalex.org/W2151259804","https://openalex.org/W2154804907","https://openalex.org/W2156359899","https://openalex.org/W2161711733","https://openalex.org/W2167246321","https://openalex.org/W2168373111","https://openalex.org/W2169442707","https://openalex.org/W2171028882","https://openalex.org/W2172882315","https://openalex.org/W2206749611","https://openalex.org/W2331919111"],"related_works":["https://openalex.org/W7113045119","https://openalex.org/W2022903755","https://openalex.org/W4387057427","https://openalex.org/W2323386051","https://openalex.org/W2104372273","https://openalex.org/W2089869714","https://openalex.org/W1974645621","https://openalex.org/W2116452148","https://openalex.org/W2022797906","https://openalex.org/W2344819016"],"abstract_inverted_index":{"G-carriers":[0,24,59],"of":[1,6,28,41,53,161,198,211,222,230,235],"the":[2,7,120,156,166,187,212,219,233,238],"functional":[3],"SNP":[4],"A118G":[5],"\u03bc-opioid":[8,42],"receptor":[9],"gene":[10],"OPRM1":[11],"have":[12],"been":[13,32],"associated":[14],"with":[15],"decreased":[16],"pain":[17,244],"sensitivity":[18,63,68],"in":[19,22,38,50,165,209,232],"men,":[20],"and":[21,47,66,132,145,163,169,178,205],"alcoholic":[23],"a":[25,51,72,97,116,140,148],"greater":[26],"effect":[27,234],"naltrexone":[29,65,85,177],"treatment":[30],"has":[31],"found.":[33],"This":[34,215],"study":[35],"investigated":[36],"differences":[37,231],"subjective":[39],"effects":[40,160,197,202],"manipulation":[43],"between":[44,203],"A":[45],"homozygotes":[46],"G":[48],"carriers":[49],"group":[52],"healthy":[54,79],"males.":[55],"We":[56],"hypothesised":[57],"that":[58],"would":[60],"show":[61],"higher":[62],"to":[64,69,184],"lower":[67],"morphine.":[70],"In":[71],"randomized":[73],"double":[74],"blind":[75],"cross-over":[76],"study,":[77],"49":[78],"males":[80],"received":[81],"morphine":[82,179],"(10":[83],"mg),":[84],"(50":[86],"mg)":[87],"or":[88,200,245],"placebo":[89],"per-orally":[90],"on":[91,101,115,139],"three":[92],"separate":[93,149],"days.":[94],"They":[95],"completed":[96],"21":[98],"variable":[99],"questionnaire":[100],"four":[102,125,213],"different":[103],"time":[104,164],"intervals":[105],"(0":[106],"min,":[107,109,111],"60":[108],"120":[110],"150":[112],"min).":[113],"Based":[114],"principal":[117,141],"component":[118,142],"analysis,":[119],"variables":[121],"were":[122,137,171],"sorted":[123],"into":[124],"components:":[126],"Lethargy":[127,168,174],",":[128,130,175],"Wellbeing":[129],"Discomfort":[131],"Other":[133,170],".":[134],"The":[135],"data":[136],"based":[138],"analysis":[143],"scores,":[144],"run":[146],"through":[147],"3x3":[150],"repeated":[151],"measure":[152],"ANOVA":[153],"for":[154,192],"all":[155],"components.":[157,214],"Significant":[158],"main":[159,196],"drug":[162,204,236],"components":[167],"observed.":[172],"For":[173],"both":[176],"gave":[180],"increased":[181],"ratings":[182],"compared":[183],"placebo,":[185],"but":[186,224],"increase":[188],"was":[189,207],"only":[190],"significant":[191,195],"naltrexone.":[193],"No":[194],"genotype":[199,206],"interaction":[201],"observed":[208],"any":[210],"might":[216],"be":[217,227],"due":[218],"low":[220],"doses":[221],"morphine,":[223],"may":[225],"also":[226],"an":[228],"indication":[229],"when":[237],"system":[239],"is":[240],"disturbed,":[241],"like":[242],"during":[243],"addiction.":[246]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-07-22T00:00:00"}
