{"id":"https://openalex.org/W2466500085","doi":"https://doi.org/10.1101/cshperspect.a028092","title":"The Intraflagellar Transport Machinery","display_name":"The Intraflagellar Transport Machinery","publication_year":2016,"publication_date":"2016-06-28","ids":{"openalex":"https://openalex.org/W2466500085","doi":"https://doi.org/10.1101/cshperspect.a028092","mag":"2466500085","pmid":"https://pubmed.ncbi.nlm.nih.gov/27352625","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5046692"},"language":"en","primary_location":{"id":"doi:10.1101/cshperspect.a028092","doi":"https://doi.org/10.1101/cshperspect.a028092","is_oa":true,"landing_page_url":"https://doi.org/10.1101/cshperspect.a028092","pdf_url":"http://cshperspectives.cshlp.org/content/8/10/a028092.full.pdf","source":{"id":"https://openalex.org/S160223955","display_name":"Cold Spring Harbor Perspectives in Biology","issn_l":"1943-0264","issn":["1943-0264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Biology","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://cshperspectives.cshlp.org/content/8/10/a028092.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046740278","display_name":"Michael John Taschner","orcid":"https://orcid.org/0000-0002-8881-3705","observed_orcids":["https://orcid.org/0000-0002-8881-3705"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Taschner","raw_affiliation_strings":["Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, D-82152 Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, D-82152 Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012945755","display_name":"Esben Lorentzen","orcid":"https://orcid.org/0000-0001-6493-7220","observed_orcids":["https://orcid.org/0000-0001-6493-7220"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Esben Lorentzen","raw_affiliation_strings":["Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, D-82152 Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, D-82152 Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210150093"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":368,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"10","first_page":"a028092","last_page":"a028092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intraflagellar-transport","display_name":"intraflagellar transport","score":1.0},{"id":"https://openalex.org/keywords/cilia","display_name":"cilia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/flagella","display_name":"flagella","score":1.0},{"id":"https://openalex.org/keywords/ciliary-assembly","display_name":"ciliary assembly","score":0.6970000267028809},{"id":"https://openalex.org/keywords/ciliopathy","display_name":"ciliopathies","score":0.8539999723434448},{"id":"https://openalex.org/keywords/ciliary-motility","display_name":"ciliary motility","score":0.7599999904632568},{"id":"https://openalex.org/keywords/ciliary-signaling","display_name":"ciliary signaling","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mammalian-development","display_name":"mammalian development","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C37590093","wikidata":"https://www.wikidata.org/wiki/Q978456","display_name":"Intraflagellar transport","level":4,"score":0.9898530840873718},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.9770255088806152},{"id":"https://openalex.org/C2910395002","wikidata":"https://www.wikidata.org/wiki/Q203031","display_name":"Ciliopathies","level":4,"score":0.9044731855392456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8421058654785156},{"id":"https://openalex.org/C115811362","wikidata":"https://www.wikidata.org/wiki/Q189998","display_name":"Flagellum","level":3,"score":0.7750875353813171},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6117963194847107},{"id":"https://openalex.org/C2781232497","wikidata":"https://www.wikidata.org/wiki/Q1678281","display_name":"Bardet\u2013Biedl syndrome","level":4,"score":0.5591964721679688},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.4750525951385498},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12019270658493042},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.05584979057312012},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.051306456327438354}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1101/cshperspect.a028092","doi":"https://doi.org/10.1101/cshperspect.a028092","is_oa":true,"landing_page_url":"https://doi.org/10.1101/cshperspect.a028092","pdf_url":"http://cshperspectives.cshlp.org/content/8/10/a028092.full.pdf","source":{"id":"https://openalex.org/S160223955","display_name":"Cold Spring Harbor Perspectives in Biology","issn_l":"1943-0264","issn":["1943-0264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5106065","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5046692","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5046692","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5046692","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harb Perspect Biol","raw_type":"Text"},{"id":"pmid:27352625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27352625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor perspectives in biology","raw_type":"Journal Article"},{"id":"pmh:oai:escidoc.org:escidoc:2367859","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-002C-403A-2","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088280","host_organization_name":"Max Planck Digital Library","host_organization_lineage":["https://openalex.org/I4210088280"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_2367859","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-002C-403A-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cold Spring Harbor Perspectives in Biology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1101/cshperspect.a028092","doi":"https://doi.org/10.1101/cshperspect.a028092","is_oa":true,"landing_page_url":"https://doi.org/10.1101/cshperspect.a028092","pdf_url":"http://cshperspectives.cshlp.org/content/8/10/a028092.full.pdf","source":{"id":"https://openalex.org/S160223955","display_name":"Cold Spring Harbor Perspectives in Biology","issn_l":"1943-0264","issn":["1943-0264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2466500085.pdf","grobid_xml":"https://content.openalex.org/works/W2466500085.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W158697384","https://openalex.org/W195123426","https://openalex.org/W235637639","https://openalex.org/W237137681","https://openalex.org/W322675697","https://openalex.org/W1508747385","https://openalex.org/W1523856032","https://openalex.org/W1531339387","https://openalex.org/W1829168284","https://openalex.org/W1899925323","https://openalex.org/W1927073684","https://openalex.org/W1963825895","https://openalex.org/W1964432969","https://openalex.org/W1964896154","https://openalex.org/W1971688911","https://openalex.org/W1976197160","https://openalex.org/W1979921735","https://openalex.org/W1980100245","https://openalex.org/W1982229009","https://openalex.org/W1983208589","https://openalex.org/W1985143102","https://openalex.org/W1989140036","https://openalex.org/W1989813669","https://openalex.org/W1990300808","https://openalex.org/W1993880917","https://openalex.org/W1994076532","https://openalex.org/W1995270654","https://openalex.org/W1995404168","https://openalex.org/W1995651171","https://openalex.org/W1996256749","https://openalex.org/W1997628120","https://openalex.org/W1998854916","https://openalex.org/W2000301861","https://openalex.org/W2001047457","https://openalex.org/W2007764395","https://openalex.org/W2008047816","https://openalex.org/W2008193057","https://openalex.org/W2010673809","https://openalex.org/W2017488523","https://openalex.org/W2026335052","https://openalex.org/W2028928264","https://openalex.org/W2029057053","https://openalex.org/W2030939638","https://openalex.org/W2032141866","https://openalex.org/W2033052818","https://openalex.org/W2033483229","https://openalex.org/W2039238855","https://openalex.org/W2041485433","https://openalex.org/W2043725913","https://openalex.org/W2047722888","https://openalex.org/W2048262130","https://openalex.org/W2051301625","https://openalex.org/W2051598523","https://openalex.org/W2053691011","https://openalex.org/W2055922206","https://openalex.org/W2057006089","https://openalex.org/W2061604906","https://openalex.org/W2065810942","https://openalex.org/W2066034930","https://openalex.org/W2068666076","https://openalex.org/W2072416931","https://openalex.org/W2072520621","https://openalex.org/W2073745454","https://openalex.org/W2074234100","https://openalex.org/W2078543134","https://openalex.org/W2078755430","https://openalex.org/W2079171495","https://openalex.org/W2081871544","https://openalex.org/W2082188981","https://openalex.org/W2083904901","https://openalex.org/W2084741786","https://openalex.org/W2084945515","https://openalex.org/W2085762494","https://openalex.org/W2086283062","https://openalex.org/W2090068859","https://openalex.org/W2091684557","https://openalex.org/W2094152798","https://openalex.org/W2094452381","https://openalex.org/W2095486148","https://openalex.org/W2097907753","https://openalex.org/W2098385247","https://openalex.org/W2100237032","https://openalex.org/W2101150738","https://openalex.org/W2103036283","https://openalex.org/W2104531203","https://openalex.org/W2105663489","https://openalex.org/W2105947646","https://openalex.org/W2106754940","https://openalex.org/W2113447712","https://openalex.org/W2114333899","https://openalex.org/W2114749367","https://openalex.org/W2115163299","https://openalex.org/W2116079099","https://openalex.org/W2117634438","https://openalex.org/W2118640963","https://openalex.org/W2121248205","https://openalex.org/W2121780565","https://openalex.org/W2122297545","https://openalex.org/W2122810646","https://openalex.org/W2123700457","https://openalex.org/W2124931121","https://openalex.org/W2125089548","https://openalex.org/W2126302545","https://openalex.org/W2126661153","https://openalex.org/W2128276285","https://openalex.org/W2129126752","https://openalex.org/W2132150149","https://openalex.org/W2135218853","https://openalex.org/W2139033561","https://openalex.org/W2140864413","https://openalex.org/W2141570562","https://openalex.org/W2145289321","https://openalex.org/W2145818287","https://openalex.org/W2147112193","https://openalex.org/W2147783201","https://openalex.org/W2148499715","https://openalex.org/W2148802709","https://openalex.org/W2150269114","https://openalex.org/W2152931318","https://openalex.org/W2154261437","https://openalex.org/W2158220085","https://openalex.org/W2159407840","https://openalex.org/W2161570516","https://openalex.org/W2161870393","https://openalex.org/W2166172589","https://openalex.org/W2166977115","https://openalex.org/W2167075028","https://openalex.org/W2168569886","https://openalex.org/W2171253503","https://openalex.org/W2173846013","https://openalex.org/W2177346644","https://openalex.org/W2287626401","https://openalex.org/W2300250224","https://openalex.org/W2336464353","https://openalex.org/W2346539852","https://openalex.org/W2348394504","https://openalex.org/W2360618002","https://openalex.org/W2383312019"],"related_works":["https://openalex.org/W4211143281","https://openalex.org/W4414021089","https://openalex.org/W2094118209","https://openalex.org/W117047863","https://openalex.org/W2095443801","https://openalex.org/W4376880376","https://openalex.org/W2593995774","https://openalex.org/W7099847286","https://openalex.org/W2079613349","https://openalex.org/W4322581885"],"abstract_inverted_index":{"Eukaryotic":[0],"cilia":[1,20],"and":[2,17,31,35,54,93,122,129],"flagella":[3],"are":[4],"evolutionarily":[5],"conserved":[6],"organelles":[7],"that":[8],"protrude":[9],"from":[10],"the":[11,42,51,72,119],"cell":[12],"surface.":[13],"The":[14],"unique":[15],"location":[16],"properties":[18],"of":[19,45,75,80,101,112,125],"allow":[21],"them":[22],"to":[23,87],"function":[24],"in":[25,70,77,95],"vital":[26],"processes":[27],"such":[28],"as":[29,105],"motility":[30],"signaling.":[32],"Ciliary":[33],"assembly":[34],"maintenance":[36],"rely":[37],"on":[38,118],"intraflagellar":[39],"transport":[40,48],"(IFT),":[41],"bidirectional":[43],"movement":[44],"a":[46,78,99,115],"multicomponent":[47],"system":[49],"between":[50],"ciliary":[52,126],"base":[53],"tip.":[55],"Since":[56],"its":[57],"initial":[58],"discovery":[59],"more":[60],"than":[61],"two":[62],"decades":[63],"ago,":[64],"considerable":[65],"effort":[66],"has":[67],"been":[68],"invested":[69],"dissecting":[71],"molecular":[73],"mechanisms":[74,124],"IFT":[76,84,113,120],"variety":[79],"model":[81],"organisms.":[82],"Importantly,":[83],"was":[85],"shown":[86],"be":[88],"essential":[89],"for":[90],"mammalian":[91],"development,":[92],"defects":[94],"this":[96],"process":[97],"cause":[98],"number":[100],"human":[102],"pathologies":[103],"known":[104],"ciliopathies.":[106],"Here,":[107],"we":[108],"review":[109],"current":[110],"knowledge":[111],"with":[114],"particular":[116],"emphasis":[117],"machinery":[121],"specific":[123],"cargo":[127],"recognition":[128],"transport.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":44},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":42},{"year":2022,"cited_by_count":43},{"year":2021,"cited_by_count":38},{"year":2020,"cited_by_count":42},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":38},{"year":2017,"cited_by_count":44},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-07-22T00:00:00"}