{"id":"https://openalex.org/W2466473274","doi":null,"title":"LPS-induced inflammatory responses and analysis of cardioprotective gene expression in mouse primary cardiac fibroblasts and cardiac myocytes","display_name":"LPS-induced inflammatory responses and analysis of cardioprotective gene expression in mouse primary cardiac fibroblasts and cardiac myocytes","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2466473274","mag":"2466473274"},"language":"en","primary_location":{"id":"pmh:oai:nmbu.brage.unit.no:11250/186550","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/186550","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11250/186550","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033454595","display_name":"Mrinal Kumar Das","orcid":"https://orcid.org/0000-0002-7749-7591","observed_orcids":["https://orcid.org/0000-0002-7749-7591"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mrinal K. Das","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7749-7591","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033454595"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/septic-cardiomyopathy","display_name":"septic cardiomyopathy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cardiac-fibroblasts","display_name":"cardiac fibroblasts","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.996999979019165},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.902999997138977},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.996999979019165},{"id":"https://openalex.org/keywords/gdf15","display_name":"GDF15","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.843999981880188},{"id":"https://openalex.org/keywords/matricellular-proteins","display_name":"matricellular proteins","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6938174366950989},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5774602293968201},{"id":"https://openalex.org/C3018686881","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac myocyte","level":3,"score":0.4817764461040497},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4600076973438263},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4433450400829315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4134898781776428},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37560492753982544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3421403765678406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3040808439254761},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1863815188407898}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:nmbu.brage.unit.no:11250/186550","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/186550","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2466473274","doi":null,"is_oa":false,"landing_page_url":"https://brage.bibsys.no/xmlui/handle/11250/186550","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:nmbu.brage.unit.no:11250/186550","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/186550","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W49841745","https://openalex.org/W78888789","https://openalex.org/W118616534","https://openalex.org/W157540157","https://openalex.org/W192578485","https://openalex.org/W647870132","https://openalex.org/W658571831","https://openalex.org/W1515994079","https://openalex.org/W1521502403","https://openalex.org/W1538768461","https://openalex.org/W1550722396","https://openalex.org/W1888999677","https://openalex.org/W1919248155","https://openalex.org/W1964842286","https://openalex.org/W1971925894","https://openalex.org/W1972934337","https://openalex.org/W1974011244","https://openalex.org/W1974429316","https://openalex.org/W1975215292","https://openalex.org/W1979076069","https://openalex.org/W1979960552","https://openalex.org/W1982431350","https://openalex.org/W1983893679","https://openalex.org/W1984437045","https://openalex.org/W1996028958","https://openalex.org/W1997093143","https://openalex.org/W1998833219","https://openalex.org/W1999512677","https://openalex.org/W1999790619","https://openalex.org/W2000439702","https://openalex.org/W2001044525","https://openalex.org/W2001564526","https://openalex.org/W2003811379","https://openalex.org/W2004487653","https://openalex.org/W2006182686","https://openalex.org/W2006468572","https://openalex.org/W2006558163","https://openalex.org/W2006919847","https://openalex.org/W2007338571","https://openalex.org/W2009929467","https://openalex.org/W2010216650","https://openalex.org/W2012126480","https://openalex.org/W2013197361","https://openalex.org/W2014547268","https://openalex.org/W2017033551","https://openalex.org/W2021132199","https://openalex.org/W2023782236","https://openalex.org/W2024774657","https://openalex.org/W2024992082","https://openalex.org/W2029157767","https://openalex.org/W2029746173","https://openalex.org/W2031353853","https://openalex.org/W2036909269","https://openalex.org/W2038460784","https://openalex.org/W2038501199","https://openalex.org/W2043513395","https://openalex.org/W2046678766","https://openalex.org/W2049927822","https://openalex.org/W2050166408","https://openalex.org/W2051266478","https://openalex.org/W2053042661","https://openalex.org/W2053865773","https://openalex.org/W2057123987","https://openalex.org/W2057198069","https://openalex.org/W2057386289","https://openalex.org/W2059451868","https://openalex.org/W2062835892","https://openalex.org/W2063695842","https://openalex.org/W2064506356","https://openalex.org/W2067420120","https://openalex.org/W2068200074","https://openalex.org/W2068365384","https://openalex.org/W2069398444","https://openalex.org/W2071465162","https://openalex.org/W2071695884","https://openalex.org/W2074994532","https://openalex.org/W2075144099","https://openalex.org/W2078575750","https://openalex.org/W2083430194","https://openalex.org/W2085952814","https://openalex.org/W2086226482","https://openalex.org/W2087203965","https://openalex.org/W2087867048","https://openalex.org/W2087920840","https://openalex.org/W2088339631","https://openalex.org/W2088915027","https://openalex.org/W2095575219","https://openalex.org/W2095833996","https://openalex.org/W2099231162","https://openalex.org/W2101108802","https://openalex.org/W2101243001","https://openalex.org/W2107206386","https://openalex.org/W2107805895","https://openalex.org/W2109560931","https://openalex.org/W2110671224","https://openalex.org/W2111180872","https://openalex.org/W2112278084","https://openalex.org/W2112417973","https://openalex.org/W2114752142","https://openalex.org/W2118098537","https://openalex.org/W2120886434","https://openalex.org/W2123987062","https://openalex.org/W2124328583","https://openalex.org/W2126012511","https://openalex.org/W2129319296","https://openalex.org/W2129501902","https://openalex.org/W2130073289","https://openalex.org/W2133341222","https://openalex.org/W2136968990","https://openalex.org/W2140174247","https://openalex.org/W2141498118","https://openalex.org/W2142070428","https://openalex.org/W2144533837","https://openalex.org/W2145162181","https://openalex.org/W2145649086","https://openalex.org/W2148142581","https://openalex.org/W2154220045","https://openalex.org/W2157101465","https://openalex.org/W2162010936","https://openalex.org/W2163738693","https://openalex.org/W2166030187","https://openalex.org/W2167636398","https://openalex.org/W2168383601","https://openalex.org/W2169804106","https://openalex.org/W2169804478","https://openalex.org/W2173272774","https://openalex.org/W2185204540","https://openalex.org/W2288348491","https://openalex.org/W2300346211","https://openalex.org/W2316578603","https://openalex.org/W2319070317","https://openalex.org/W2322434197","https://openalex.org/W2328385897","https://openalex.org/W2332881305","https://openalex.org/W2333242047","https://openalex.org/W2394914850","https://openalex.org/W2404378449","https://openalex.org/W2405578227","https://openalex.org/W2411628700","https://openalex.org/W2412282524","https://openalex.org/W2415945904","https://openalex.org/W2768146862","https://openalex.org/W2911242374"],"related_works":["https://openalex.org/W1993169730","https://openalex.org/W2019959697","https://openalex.org/W1806528843","https://openalex.org/W2179584574","https://openalex.org/W3032799009","https://openalex.org/W2095072263","https://openalex.org/W4296046228","https://openalex.org/W178922339","https://openalex.org/W2773091346","https://openalex.org/W1578735843"],"abstract_inverted_index":{"Sepsis,":[0],"an":[1,6],"uncontrolled":[2],"inflammatory":[3],"response":[4],"is":[5],"important":[7],"cause":[8],"of":[9,18,23,100,122,134,158,176,192,195,213,216,235,237,246,272,292,304,316,320,327,345,368,380],"death":[10,319,354],"among":[11],"the":[12,58,60,78,98,115,119,130,137,156,211,242,255,268,342,366],"critically":[13],"ill":[14],"patients.":[15],"Several":[16,39],"lines":[17],"evidences":[19],"have":[20,102],"confirmed":[21],"depression":[22],"myocardial":[24,35,55],"function":[25],"in":[26,37,53,65,89,105,129,136,199,208,229,254,265,278,296,311,330,355,370],"sepsis":[27],"which":[28],"led":[29],"researchers":[30],"to":[31,85,166,222,261,282,308,364],"focus":[32],"intensely":[33],"on":[34],"dysfunction":[36,91],"sepsis.":[38],"studies":[40],"reported":[41],"that":[42,228,241],"LPS-induced":[43,317,352],"pro-inflammatory":[44],"cytokines,":[45],"TNF-\u03b1":[46,196,217,248,273],"and":[47,77,92,110,118,127,143,149,170,180,197,205,218,249,274,294,349],"IL-1\u03b2":[48,198,219,250,275],"play":[49,86],"a":[50],"key":[51],"role":[52],"sepsis-induced":[54],"dysfunction.":[56],"On":[57],"contrary,":[59],"secreted":[61],"CCN":[62],"matricellular":[63],"proteins,":[64],"particular":[66],"CCN2/CTGF":[67],"(connective":[68],"tissue":[69],"growth":[70],"factor),":[71],"CCN5/WISP-2":[72],"(Wnt1-inducible":[73],"signalling":[74],"pathway":[75],"protein-2)":[76],"TGF-\u03b2":[79],"superfamily":[80],"cytokine,":[81],"GDF-15":[82],"were":[83,220,251,306],"shown":[84],"cardioprotective":[87],"roles":[88],"cardiac":[90,108,111,141,144,162,203,209,230,238,258,266,299,313,322,332,356,377],"remodelling.":[93],"In":[94,285,335],"our":[95,336],"present":[96],"study,":[97],"effects":[99,344,367],"LPS":[101,135,167,256,297,369],"been":[103],"investigated":[104,155],"adult":[106,138,159,201,321],"mouse":[107,139,160,202,374],"fibroblasts":[109,142,204,210,239,259],"myocytes.":[112,206,231,314],"We":[113,153],"assessed":[114],"mRNA":[116,193,214,302],"levels":[117,121,194,245,271,303],"protein":[120,244,270],"TNF-\u03b1,":[123],"IL-1\u03b2,":[124],"CCN2,":[125,347],"CCN5":[126,295,348],"GDF15":[128,305,350],"absence":[131],"or":[132],"presence":[133],"primary":[140,161],"myocytes":[145,163,267,323],"by":[146,183],"real-time":[147],"q-PCR":[148,189],"Western":[150,232],"blot":[151,233],"analyses.":[152],"also":[154,361],"viability":[157,329],"after":[164],"exposure":[165],"(0.1":[168],"\u03bcg/ml":[169],"10":[171],"\u03bcg/ml)":[172],"for":[173],"different":[174],"periods":[175],"time":[177],"(0,":[178],"3,6,12":[179],"24":[181],"hours)":[182],"trypan":[184],"blue":[185],"exclusion":[186],"assay.":[187],"Real-time":[188],"demonstrates":[190,324],"induction":[191,212],"LPS-treated":[200,279,312,331],"Particularly,":[207],"expressions":[215],"found":[221,307],"be":[223,309,362],"much":[224],"more":[225],"robust":[226],"than":[227],"analysis":[234,289],"extracts":[236],"revealed":[240,290],"precursor":[243,269],"both":[247],"significantly":[252],"induced":[253],"stimulated":[257,298],"compared":[260,281],"non-stimulated":[262],"cells.":[263,284],"However,":[264],"remained":[276],"unchanged":[277],"cells":[280],"control":[283],"addition,":[286],"gene":[287],"expression":[288],"down-regulation":[291],"CCN2":[293],"fibroblasts,":[300],"whereas":[301],"up-regulated":[310],"Assessment":[315],"cell":[318,328,353,357],"significant":[325],"decrease":[326],"myocyte":[333],"cultures.":[334,358],"future":[337],"studies,":[338],"we":[339],"will":[340],"investigate":[341],"cytoprotective":[343],"recombinant":[346],"at":[351],"It":[359],"would":[360],"interesting":[363],"delineate":[365],"vivo":[371],"using":[372],"CCN2-transgenic":[373],"model":[375],"with":[376],"specific":[378],"overexpression":[379],"CCN2.":[381]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-07-22T00:00:00"}