{"id":"https://openalex.org/W2466282957","doi":"https://doi.org/10.1227/01.neu.0000473809.76102.ee","title":"Excitotoxic SLC7A11 Expression Is a Marker of Poor Glioblastoma Survival and a Potential Therapeutic Target","display_name":"Excitotoxic SLC7A11 Expression Is a Marker of Poor Glioblastoma Survival and a Potential Therapeutic Target","publication_year":2015,"publication_date":"2015-11-20","ids":{"openalex":"https://openalex.org/W2466282957","doi":"https://doi.org/10.1227/01.neu.0000473809.76102.ee","mag":"2466282957","pmid":"https://pubmed.ncbi.nlm.nih.gov/26584321"},"language":"en","primary_location":{"id":"doi:10.1227/01.neu.0000473809.76102.ee","doi":"https://doi.org/10.1227/01.neu.0000473809.76102.ee","is_oa":false,"landing_page_url":"https://doi.org/10.1227/01.neu.0000473809.76102.ee","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018164562","display_name":"Ray R. Zhang","orcid":"https://orcid.org/0000-0001-8056-3599","observed_orcids":["https://orcid.org/0000-0001-8056-3599"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray R. Zhang","raw_affiliation_strings":["University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003800857","display_name":"Kelli B. Pointer","orcid":"https://orcid.org/0000-0001-9383-0000","observed_orcids":["https://orcid.org/0000-0001-9383-0000"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelli B. Pointer","raw_affiliation_strings":["University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054371127","display_name":"John S. Kuo","orcid":"https://orcid.org/0000-0001-6809-4806","observed_orcids":["https://orcid.org/0000-0001-6809-4806"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Kuo","raw_affiliation_strings":["University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":0.9326,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76106735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"77","issue":"6","first_page":"N16","last_page":"N17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/slc7a11","display_name":"SLC7A11","score":0.9990000128746033},{"id":"https://openalex.org/keywords/system-xc","display_name":"system xc-","score":0.9449999928474426},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.7210000157356262},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.7179999947547913},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.8299999833106995},{"id":"https://openalex.org/keywords/glutamate-receptor-antagonists","display_name":"glutamate receptor antagonists","score":0.7580000162124634},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7210000157356262},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cysteine-uptake","display_name":"cysteine uptake","score":0.6259999871253967},{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.44699999690055847},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.8856614828109741},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.7882575392723083},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6914863586425781},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4988117218017578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46344804763793945},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.44194889068603516},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3806249499320984},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35474103689193726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31639009714126587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20308047533035278},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1729305386543274},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10363900661468506},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08023306727409363}],"mesh":[{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027182","descriptor_name":"Amino Acid Transport System y+","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1227/01.neu.0000473809.76102.ee","doi":"https://doi.org/10.1227/01.neu.0000473809.76102.ee","is_oa":false,"landing_page_url":"https://doi.org/10.1227/01.neu.0000473809.76102.ee","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:26584321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26584321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"News"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7553671288","display_name":"Integrated Training For Physician-Scientists","funder_award_id":"T32GM008692","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2099513242"],"related_works":["https://openalex.org/W2099513242","https://openalex.org/W4253899561","https://openalex.org/W2552779095","https://openalex.org/W2598613593","https://openalex.org/W4408449380","https://openalex.org/W3195158407","https://openalex.org/W6927465792","https://openalex.org/W2070375246","https://openalex.org/W6889934982","https://openalex.org/W2767273323"],"abstract_inverted_index":{"Glioblastoma":[0],"(GBM)":[1],"is":[2,40,46,53,66,81,124,455,571,674,790],"the":[3,59,67,91,217,267,301,339,343,462,596,623,869],"most":[4],"common":[5],"adult":[6],"primary":[7],"brain":[8,129,186,359,395,612],"cancer,":[9],"and":[10,25,45,119,134,154,183,244,523,530,568,585,605,646,678,695,727,743,763,794,826,835,850,858,873],"approximately":[11],"half":[12,206,219],"of":[13,23,58,107,180,189,261,303,355,361,387,413,423,432,452,473,526,593,633,668,734,741,747,871],"GBM":[14,50,182,201,278,764,818,843,856],"patients":[15,202,509,567,594,644,799],"have":[16],"seizures":[17,44,351,427,793],"that":[18,35,55,86,156,204,369,441,569,838],"significantly":[19,377],"alter":[20],"their":[21],"quality":[22],"life":[24],"complicate":[26],"clinical":[27,450,495],"management.":[28],"Recent":[29],"research":[30],"supports":[31,87],"an":[32,37,176,294,648],"emerging":[33],"hypothesis":[34],"glutamate,":[36,662],"excitatory":[38],"neurotransmitter,":[39],"partially":[41],"responsible":[42],"for":[43,76,559,817,859],"associated":[47,791],"with":[48,195,238,257,276,284,287,306,311,318,330,333,364,383,398,409,416,419,429,435,466,484,510,601,610,622,680,697,777,792,800],"worse":[49],"survival.":[51],"It":[52],"postulated":[54],"glioma":[56,165,308,313,320,335,365,374,566,616,643,702,720,749],"upregulation":[57],"system":[60,577],"xc\u2212":[61],"(SXC)":[62,580],"cysteine/glutamate":[63],"exchanger":[64],"(SLC7A11":[65],"key":[68,557],"catalytic":[69],"subunit)":[70],"causes":[71],"glutamate":[72,93,262,345,505,519,544,587,635,669,676],"release":[73,346],"in":[74,83,127,142,175,193,199,253,297,300,358,392,403,507,543,548,561,564,595,642,700,798,823,876],"exchange":[75],"tumor":[77,88],"cysteine":[78],"uptake.":[79],"Cysteine":[80],"used":[82,501],"glutathione":[84],"synthesis":[85],"proliferation.":[89],"Therefore,":[90],"released":[92],"accumulates":[94],"to":[95,162,212,226,349,421,445,502,513,682,820],"a":[96,150,491,527,540,556,572,665,813],"high":[97,113,467,550,602,742,809],"level":[98],"around":[99],"GBMs,":[100],"inducing":[101],"seizures,":[102],"mediating":[103],"excitotoxicity":[104,123,563],"(increased":[105],"firing":[106],"surrounding":[108],"normal":[109,185,197,213,227,273],"neuronal":[110],"cells)":[111],"through":[112,630],"calcium":[114,249],"influx":[115,250],"into":[116],"peritumoral":[117,184,298,356,370,504,518,562,586,634,661,827],"neurons,":[118],"causing":[120],"apoptosis.":[121],"Pathogenic":[122],"already":[125],"implicated":[126],"traumatic":[128],"injury,":[130],"neurodegenerative":[131],"diseases,":[132],"stroke,":[133],"epilepsy.":[135],"Robert":[136,167,780],"et":[137,168,786],"al1":[138],"directly":[139],"implicate":[140],"SLC7A11":[141,147,172,209,486,560,603,607,698,745,766,788,810,872],"glioma-associated":[143,232,447],"seizure":[144,405],"activity,":[145],"establish":[146,231,808],"expression":[148,174,472,487,581,609,699,767,789,811,870],"as":[149,664,812,855],"poor":[151,796,814],"prognostic":[152,815],"marker,":[153],"show":[155],"SXC":[157,190,223,533,833,853],"inhibitors":[158,854],"are":[159,692],"potentially":[160],"useful":[161],"treat":[163,841],"SXC-positive":[164],"patients.":[166,844],"al":[169],"first":[170],"analyzed":[171,621],"protein":[173,191],"annotated":[177],"tissue":[178,198,703,712,765],"microarray":[179],"patient-matched":[181],"tissue.":[187,750],"Comparison":[188],"levels":[192,506,545],"GBMs":[194],"matched":[196],"41":[200],"showed":[203,293,368,539],"about":[205,430],"highly":[207],"express":[208,222],"(1.17":[210],"relative":[211,225],"tissue,":[214,228],"SLC7A11hi),":[215],"whereas":[216],"other":[218],"did":[220],"not":[221],"(0.08":[224],"SLC7A11neg).":[229],"To":[230],"excitotoxicity,":[233],"cortical":[234,254],"neurons":[235,255,274,299,357,371],"were":[236,279,376],"treated":[237,256],"conditioned":[239],"medium":[240],"derived":[241],"from":[242,461,779],"SLC7A11hi":[243,277,307,319,373,393],"SLC7A11neg":[245,288,312,334,399,436],"glioblastomas.":[246],"Significantly":[247],"more":[248,378,865],"was":[251,407,500,520],"seen":[252],"SLC7A11hi-conditioned":[258],"medium.":[259],"Addition":[260],"receptor":[263],"antagonists":[264],"effectively":[265,840],"blocked":[266],"Ca++":[268],"influx.":[269],"In":[270,290,490,516,863],"cocultured":[271,286],"experiments,":[272],"grown":[275],"substantially":[280],"less":[281,481],"viable":[282],"compared":[283,310,329,382,397,428,696],"those":[285,483],"GBM.":[289],"vivo":[291,404],"testing":[292],"80%":[295],"reduction":[296],"brains":[302],"mice":[304,316,331,362,414,425,433],"implanted":[305,317,332,363,415,434],"cells":[309,321],"cells.":[314,366],"The":[315,449],"also":[322,831],"demonstrated":[323,408],"shortened":[324],"mean":[325,730],"survival":[326,460,584,591,797],"(20-22":[327],"days)":[328],"(27-32":[336],"days).":[337],"Next,":[338],"authors":[340],"assessed":[341,521],"whether":[342],"SLC7A11-mediated":[344],"may":[347,839],"lead":[348],"tumor-associated":[350,861],"by":[352,457,638,706],"patch-clamp":[353],"analysis":[354,733],"slices":[360,396],"Recordings":[367],"near":[372],"xenografts":[375],"depolarized":[379],"at":[380],"baseline":[381],"controls.":[384],"Pharmacological":[385],"induction":[386],"excitability":[388],"increased":[389,446],"epileptiform":[390],"activity":[391],"xenograft":[394,400],"slices.":[401],"Enhanced":[402],"susceptibility":[406],"continuous":[410],"electroencephalography":[411],"monitoring":[412],"SLC7A11-expressing":[417,468,551,842],"GBM,":[418],"70%":[420],"77%":[422],"such":[424],"developing":[426],"10%":[431],"gliomas.":[437,515,878],"These":[438],"findings":[439,807],"illustrate":[440],"SLC7A11-induced":[442],"hyperexcitability":[443],"leads":[444],"seizures.":[448,862],"relevance":[451],"these":[453],"data":[454],"validated":[456],"SLC7A11-stratified":[458],"patient":[459,583,701,748],"REMBRANDT":[463,597],"database:":[464],"Patients":[465],"tumors":[469],"(\u2265150%":[470],"mRNA":[471],"nonneoplastic":[474,611],"brain)":[475],"on":[476],"average":[477],"lived":[478],"9":[479,508],"months":[480],"than":[482],"low":[485,606,744],"(\u226466%;":[488],"Figure).":[489],"pilot":[492],"randomized":[493],"prospective":[494],"trial,":[496],"magnetic":[497,639],"resonance":[498,537,640],"spectroscopy":[499,538,641],"assess":[503],"grade":[511],"II":[512],"IV":[514],"addition,":[517,864],"before":[522,645],"after":[524,546,647,688],"administration":[525,690],"US":[528],"Food":[529],"Drug":[531],"Administration\u2013approved":[532],"inhibitor,":[534],"sulfasalazine.":[535],"Magnetic":[536],"greater":[541],"decrease":[542,762],"sulfasalazine":[547],"biopsy-proven,":[549],"tumors.":[552],"This":[553,829],"strongly":[554],"suggest":[555],"role":[558,822,875],"human":[565],"it":[570],"valid":[573],"druggable":[574],"target.Figure:":[575],"Glioma":[576],"xc":[578],"\u2212":[579],"predicts":[582,795],"response.":[588],"A,":[589],"Kaplan-Meier":[590,620],"plot":[592],"database":[598],"comparing":[599],"gliomas":[600],"(\u2265150%)":[604],"(\u226466%)":[608],"(n":[613,709],"=":[614,627,710,718,753,771,774],"120":[615],"[all":[617],"grades]":[618],"patients;":[619],"log-rank":[624],"test,":[625],"P":[626,736],".02).":[628],"B":[629],"E,":[631,756],"detection":[632],"(Glx)":[636],"measured":[637],"acute":[649],"SAS":[650,689],"dose":[651],"(1":[652],"g).":[653],"B,":[654],"representative":[655],"images":[656],"showing":[657],"voxel":[658],"placement.":[659],"C,":[660],"detected":[663],"peak":[666],"composed":[667],"+":[670],"glutamine":[671],"(Glx),":[672],"which":[673],"predominantly":[675],"(27),":[677],"quantified":[679,705],"respect":[681],"creatine":[683],"(Cr).":[684],"Intracranial":[685],"Glx/Cr":[686,761],"changes":[687],"(Post-SAS)":[691],"graphed":[693],"(bottom)":[694],"(top)":[704],"staining":[707,746],"intensity":[708],"3":[711],"samples":[713],"per":[714],"patient;":[715],"total":[716],"n":[717],"27;":[719],"types":[721],"include":[722],"glioblastoma":[723],"[GBM],":[724],"astrocytoma":[725],"[Astro],":[726],"oligodendroglioma/oligoastrocytoma":[728],"[Oligo];":[729],"\u00b1":[731],"SEM;":[732],"variance,":[735],"<":[737],".001).":[738],"D,":[739],"examples":[740],"Scale":[751],"bars":[752],"100":[754],"mmol/L.":[755],"linear":[757],"correlation":[758],"between":[759],"maximum":[760],"(linear":[768],"regression;":[769],"*P":[770],".0134;":[772],"R2":[773],"0.9996).":[775],"Reprinted":[776],"permission":[778],"SM,":[781],"Buckingham":[782],"SC,":[783],"Campbell":[784],"SL,":[785],"al.":[787],"malignant":[801],"glioma.":[802],"Sci":[803],"Transl":[804],"Med.":[805],"2015;7(289):289ra76.These":[806],"marker":[816],"owing":[819],"its":[821,874],"promoting":[824],"growth":[825],"excitotoxicity.":[828],"study":[830],"identified":[832],"inhibition":[834],"candidate":[836],"drugs":[837],"Further":[845],"work":[846],"should":[847,867],"develop,":[848],"optimize,":[849],"clinically":[851],"evaluate":[852],"therapies":[857],"managing":[860],"studies":[866],"explore":[868],"lower-grade":[877]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
