{"id":"https://openalex.org/W2465845291","doi":null,"title":"Oxidative DNA damage following in vivo exposure to Benzo(a)pyrene in the testis, lung and liver of wild type and Ogg1-deficient mice","display_name":"Oxidative DNA damage following in vivo exposure to Benzo(a)pyrene in the testis, lung and liver of wild type and Ogg1-deficient mice","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2465845291","mag":"2465845291"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/11800","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/11800","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/11800","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018973607","display_name":"Silje Lied","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Silje Lied","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018973607"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.16249999403953552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9549999833106995},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.9580000042915344},{"id":"https://openalex.org/keywords/8-oxoguanine","display_name":"8-oxoguanine","score":0.800000011920929},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.48500001430511475},{"id":"https://openalex.org/keywords/male-germ-cells","display_name":"male germ cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/round-spermatids","display_name":"round spermatids","score":0.968999981880188},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.8730000257492065},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.5339999794960022},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.9380000233650208},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":1.0},{"id":"https://openalex.org/keywords/sperm-quality","display_name":"semen quality","score":0.5690000057220459},{"id":"https://openalex.org/keywords/testicular-cancer","display_name":"testicular cancer","score":0.6859999895095825},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.656000018119812},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.3840000033378601},{"id":"https://openalex.org/keywords/environmental-genotoxicity","display_name":"environmental genotoxicity","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.7683727145195007},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6541250348091125},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.5502347350120544},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5347625017166138},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5258610248565674},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.43575847148895264},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4212223291397095},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.36887890100479126},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.35476547479629517},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3434615135192871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3025512397289276},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.29934796690940857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29763221740722656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2900528609752655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2614749073982239},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.2540724277496338},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1679433286190033}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/11800","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/11800","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2465845291","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/bitstream/10852/11800/1/Lied.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/11800","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/11800","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W61539548","https://openalex.org/W142539256","https://openalex.org/W1279394118","https://openalex.org/W1487243507","https://openalex.org/W1722178794","https://openalex.org/W1881840670","https://openalex.org/W1926290889","https://openalex.org/W1937254250","https://openalex.org/W1973428256","https://openalex.org/W1974412402","https://openalex.org/W1974648730","https://openalex.org/W1981015212","https://openalex.org/W1982257809","https://openalex.org/W1986538990","https://openalex.org/W1986711815","https://openalex.org/W1988122871","https://openalex.org/W1993213162","https://openalex.org/W1997341599","https://openalex.org/W1999000670","https://openalex.org/W1999928710","https://openalex.org/W2001507834","https://openalex.org/W2005356916","https://openalex.org/W2007601885","https://openalex.org/W2008980299","https://openalex.org/W2010237889","https://openalex.org/W2010423267","https://openalex.org/W2011118373","https://openalex.org/W2011734211","https://openalex.org/W2012342785","https://openalex.org/W2013292325","https://openalex.org/W2014168546","https://openalex.org/W2016134181","https://openalex.org/W2020361126","https://openalex.org/W2021363087","https://openalex.org/W2024712394","https://openalex.org/W2025836541","https://openalex.org/W2029243559","https://openalex.org/W2029322058","https://openalex.org/W2029699871","https://openalex.org/W2031054920","https://openalex.org/W2034616285","https://openalex.org/W2035538685","https://openalex.org/W2036100452","https://openalex.org/W2038919867","https://openalex.org/W2040530338","https://openalex.org/W2042316019","https://openalex.org/W2045727840","https://openalex.org/W2048366042","https://openalex.org/W2050224588","https://openalex.org/W2052089730","https://openalex.org/W2052178794","https://openalex.org/W2056862882","https://openalex.org/W2065758000","https://openalex.org/W2067243965","https://openalex.org/W2067264255","https://openalex.org/W2069784172","https://openalex.org/W2070097578","https://openalex.org/W2070597848","https://openalex.org/W2074559096","https://openalex.org/W2077933167","https://openalex.org/W2078564648","https://openalex.org/W2079681465","https://openalex.org/W2080141226","https://openalex.org/W2081676666","https://openalex.org/W2085216390","https://openalex.org/W2086592404","https://openalex.org/W2087290238","https://openalex.org/W2087753682","https://openalex.org/W2089250591","https://openalex.org/W2091518382","https://openalex.org/W2094160671","https://openalex.org/W2094774309","https://openalex.org/W2095496033","https://openalex.org/W2097420884","https://openalex.org/W2099824652","https://openalex.org/W2103122715","https://openalex.org/W2103992678","https://openalex.org/W2104336168","https://openalex.org/W2105172446","https://openalex.org/W2107277218","https://openalex.org/W2110675408","https://openalex.org/W2110722235","https://openalex.org/W2111200869","https://openalex.org/W2113320982","https://openalex.org/W2115075252","https://openalex.org/W2116598568","https://openalex.org/W2119688568","https://openalex.org/W2121428578","https://openalex.org/W2123490472","https://openalex.org/W2126917185","https://openalex.org/W2132035145","https://openalex.org/W2139611206","https://openalex.org/W2147914291","https://openalex.org/W2148984745","https://openalex.org/W2156896172","https://openalex.org/W2157933551","https://openalex.org/W2162396341","https://openalex.org/W2163455087","https://openalex.org/W2163663923","https://openalex.org/W2164095252","https://openalex.org/W2166870789","https://openalex.org/W2167463754","https://openalex.org/W2168420558","https://openalex.org/W2171066719","https://openalex.org/W2171414456","https://openalex.org/W2314948707","https://openalex.org/W2411195645","https://openalex.org/W2414651941","https://openalex.org/W2461295505","https://openalex.org/W2588254949"],"related_works":["https://openalex.org/W2299918778","https://openalex.org/W2048366042","https://openalex.org/W4400885963","https://openalex.org/W2115075252","https://openalex.org/W2119699609","https://openalex.org/W2139589257","https://openalex.org/W2066061165","https://openalex.org/W6981361872","https://openalex.org/W2098823639","https://openalex.org/W1663185096"],"abstract_inverted_index":{"In":[0],"the":[1,12,16,33,41,50,58,62,69,73,77,81,86,89,126,231,336,350,368,397,413,417,449,459,500,508,517,520,553,579,582,595],"industrial":[2],"communities":[3],"of":[4,15,26,37,68,75,88,139,146,151,171,192,207,230,240,261,326,339,349,354,375,381,448,466,474,485,491,546],"today":[5],"there":[6,132],"is":[7,92,128,133,162,176,587],"reason":[8],"for":[9,11,53,222,285,305,575],"concern":[10],"reproductive":[13],"health":[14],"male,":[17],"due":[18],"to":[19,61,97,114,164,198,219,225,238,268,307,322,563],"decreasing":[20],"sperm":[21,104,108],"quality":[22,109],"and":[23,30,55,80,110,131,160,214,271,311,344,431,468,530,543,548],"increased":[24,379],"incidences":[25],"testicular":[27,38,256],"cancer.":[28,148],"Norway":[29],"Denmark":[31],"have":[32,121,142,251,273],"highest":[34],"incidence":[35],"rates":[36,124],"cancer":[39],"in":[40,102,317,362,367,387,396,401,412,416,438,443,446,456,481,498,507,513,527,541,565,589,594],"world.":[42],"There":[43],"has":[44,183],"traditionally":[45],"been":[46,184],"more":[47,346,420,523],"focus":[48],"on":[49,57,72,200,235,519,578],"maternal":[51,82],"contribution":[52],"infertility":[54],"defects":[56],"offspring":[59,70],"compared":[60,267],"paternal":[63,78,90],"contribution.":[64],"The":[65,324,378,464,488,539],"genetic":[66],"constitution":[67],"depends":[71],"integrity":[74,87],"both":[76,428,486,528],"(sperm)":[79],"(oocyte)":[83],"genomes.":[84],"When":[85],"genome":[91],"challenged":[93],"it":[94,525],"may":[95,244,301],"lead":[96],"serious":[98],"conditions;":[99],"Oxidative":[100,391],"damage":[101,168,242,263,364,383,392,440,461,556,586],"human":[103,255,340],"correlates":[105],"with":[106,425,458,472,552],"poor":[107,259],"reduced":[111],"fecundity":[112],"(ability":[113],"conceive":[115],"children).":[116],"Couples":[117],"undergoing":[118],"assisted":[119],"fertilisation":[120],"lower":[122],"success":[123],"when":[125],"father":[127],"a":[129,143,177,201,227,281,359,407,419],"smoker,":[130],"epidemiological":[134],"data":[135],"suggesting":[136],"that":[137,182,243,254,276,295,312,561,584],"children":[138],"smoking":[140],"fathers":[141],"higher":[144,495],"risk":[145],"developing":[147],"One":[149],"component":[150],"cigarette":[152],"smoke,":[153],"Benzo(a)pyrene":[154],"(BaP),":[155],"induce":[156,568],"bulky":[157,287],"DNA":[158,241,248,288,460,555],"adducts":[159],"also":[161,274,394],"believed":[163],"cause":[165],"oxidised":[166],"base":[167],"through":[169],"generation":[170],"reactive":[172],"oxygen":[173],"species":[174],"(ROS).\\nBaP":[175],"polycyclic":[178],"aromatic":[179],"hydrocarbon":[180],"(PAH)":[181],"studied":[185],"extensively.":[186],"PAHs":[187,199],"are":[188,196,597],"an":[189],"ubiquitous":[190],"class":[191],"environmental":[193,309,355],"contaminants.":[194],"We":[195,250,571],"exposed":[197],"daily":[202],"basis":[203],"from":[204,320],"food,":[205],"burning":[206],"fossil":[208],"fuels,":[209],"forest":[210],"fire,":[211],"tobacco":[212],"smoke":[213],"diesel":[215],"exhaust.":[216],"This":[217],"exposure":[218,306,480,562],"humans":[220],"qualifies":[221],"extensive":[223],"studies":[224],"achieve":[226],"good":[228],"understanding":[229],"possible":[232,351],"negative":[233],"effects":[234,353],"humans.\\nBaP-exposure":[236],"leads":[237],"induction":[239,422,473,518,577],"be":[245,302,315],"removed":[246],"via":[247],"repair.":[249],"previously":[252],"shown":[253,275],"cells":[257,279,343,592],"exhibit":[258,280],"repair":[260,327,337],"oxidative":[262,363,382,439,554,569,585],"such":[264,330],"as":[265,331],"8-oxoG,":[266],"rodents.":[269],"We,":[270],"others,":[272],"male":[277,296,341,590],"germ":[278,297,342,591],"low":[282],"NER":[283],"function":[284],"several":[286],"adducts,":[289],"including":[290],"BPDE-adducts.":[291],"These":[292],"findings":[293],"indicate":[294],"cells,":[298],"particularly":[299,303],"human,":[300],"sensitive":[304],"certain":[308],"agents":[310],"care":[313],"should":[314],"taken":[316],"extrapolating":[318],"results":[319],"rodents":[321],"man.":[323],"use":[325],"deficient":[328],"mice,":[329,333],"Ogg1-/-":[332,376,402],"thus":[334],"mimics":[335],"capacity":[338],"allows":[345],"relevant":[347],"analyses":[348],"genotoxic":[352],"agents.\\nIn":[356],"this":[357],"study":[358],"small":[360,408],"increase":[361,409],"was":[365,393,410,423,470,493,503,522],"observed":[366,411,442],"testis":[369,509],"at":[370,404,427,476,510,533],"Day":[371,405,429,432,477,511],"31":[372,406,433],"following":[373,454,479,505,537],"BaP-exposure":[374,455,506],"mice.":[377],"levels":[380,462,545,557],"were":[384,441],"most":[385],"evident":[386],"haploid":[388],"round":[389],"spermatids.":[390],"induced":[395,504,588],"somatic":[398],"tissues":[399,450,483],"investigated":[400],"mice;":[403],"liver":[414,596],"whereas":[415,516,581],"lung":[418,521,580],"pronounced":[421],"detected,":[424],"increases":[426,437],"17":[430,512],"after":[434],"exposure.":[435],"No":[436],"Ogg1+/+":[444,514],"mice":[445,515],"any":[447],"investigated.":[451],"NADP/NADPH-ratios":[452,542],"declined":[453],"line":[457],"observed.":[463,558],"expression":[465,490,544],"Cyp1a1":[467,475,497,547],"Akr1a4":[469,492,502,549],"studied,":[471],"1":[478],"all":[482,499],"examined":[484],"genotypes.":[487],"constitutive":[489],"significantly":[494],"than":[496],"tissues.":[501],"apparent,":[524],"occurred":[526],"genotypes":[529],"took":[531],"place":[532],"earlier":[534],"time":[535],"points":[536],"BaP-exposure.":[538],"decline":[540],"correspond":[550],"well":[551],"\\nWe":[559],"conclude":[560],"BaP":[564],"vivo":[566],"do":[567],"damage.":[570],"provide":[572],"solid":[573],"evidence":[574],"its":[576],"indications":[583],"or":[593],"still":[598],"unresolved.":[599]},"counts_by_year":[],"updated_date":"2026-09-03T10:48:47.769340","created_date":"2016-07-22T00:00:00"}
