{"id":"https://openalex.org/W2465766862","doi":null,"title":"Development of linkage and association methods to map disease genes.","display_name":"Development of linkage and association methods to map disease genes.","publication_year":2002,"publication_date":"2002-10-28","ids":{"openalex":"https://openalex.org/W2465766862","mag":"2465766862"},"language":"en","primary_location":{"id":"pmh:oai:repository.lib.ncsu.edu:1840.16/3139","doi":null,"is_oa":true,"landing_page_url":"http://www.lib.ncsu.edu/resolver/1840.16/3139","pdf_url":"http://www.lib.ncsu.edu/resolver/1840.16/3139","source":{"id":"https://openalex.org/S4306402468","display_name":"NCSU Libraries Repository (North Carolina State University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I137902535","host_organization_name":"North Carolina State University","host_organization_lineage":["https://openalex.org/I137902535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.lib.ncsu.edu/resolver/1840.16/3139","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025154293","display_name":"Wenlei Liu","orcid":"https://orcid.org/0000-0001-6425-9466","observed_orcids":["https://orcid.org/0000-0001-6425-9466"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wenlei Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6425-9466","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025154293"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease-gene-mapping","display_name":"disease gene mapping","score":0.7179999947547913},{"id":"https://openalex.org/keywords/linkage-analysis","display_name":"linkage analysis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/association-analysis","display_name":"association analysis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/identity-by-descent","display_name":"identity by descent","score":0.7059999704360962},{"id":"https://openalex.org/keywords/identity-by-state","display_name":"identity by state","score":0.7310000061988831},{"id":"https://openalex.org/keywords/inbreeding","display_name":"inbreeding","score":0.925000011920929},{"id":"https://openalex.org/keywords/inbreeding-coefficient","display_name":"inbreeding coefficient","score":0.6769999861717224},{"id":"https://openalex.org/keywords/false-positive-rate","display_name":"false positive rate","score":0.6650000214576721},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.7160000205039978},{"id":"https://openalex.org/keywords/qtl-mapping","display_name":"QTL mapping","score":0.8399999737739563},{"id":"https://openalex.org/keywords/expectation-maximization-algorithm","display_name":"expectation-maximization algorithm","score":0.7049999833106995},{"id":"https://openalex.org/keywords/first-cousin-marriage","display_name":"first cousin marriage","score":0.6769999861717224},{"id":"https://openalex.org/keywords/affected-sib-pairs","display_name":"affected sib pairs","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.6504279971122742},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.564693808555603},{"id":"https://openalex.org/C134443026","wikidata":"https://www.wikidata.org/wiki/Q4809584","display_name":"Association mapping","level":5,"score":0.5170108079910278},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5044811964035034},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4956780672073364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4892992675304413},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4836179316043854},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4559015929698944},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.425989031791687},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.3466583490371704},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.13746854662895203},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13214609026908875},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12405768036842346},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.lib.ncsu.edu:1840.16/3139","doi":null,"is_oa":true,"landing_page_url":"http://www.lib.ncsu.edu/resolver/1840.16/3139","pdf_url":"http://www.lib.ncsu.edu/resolver/1840.16/3139","source":{"id":"https://openalex.org/S4306402468","display_name":"NCSU Libraries Repository (North Carolina State University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I137902535","host_organization_name":"North Carolina State University","host_organization_lineage":["https://openalex.org/I137902535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:2465766862","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/3105","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.lib.ncsu.edu:1840.16/3139","doi":null,"is_oa":true,"landing_page_url":"http://www.lib.ncsu.edu/resolver/1840.16/3139","pdf_url":"http://www.lib.ncsu.edu/resolver/1840.16/3139","source":{"id":"https://openalex.org/S4306402468","display_name":"NCSU Libraries Repository (North Carolina State University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I137902535","host_organization_name":"North Carolina State University","host_organization_lineage":["https://openalex.org/I137902535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2465766862.pdf","grobid_xml":"https://content.openalex.org/works/W2465766862.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W10333642","https://openalex.org/W30312686","https://openalex.org/W96717503","https://openalex.org/W138675020","https://openalex.org/W139851368","https://openalex.org/W160329800","https://openalex.org/W230734760","https://openalex.org/W246520654","https://openalex.org/W1484562168","https://openalex.org/W1488079683","https://openalex.org/W1495147141","https://openalex.org/W1499143852","https://openalex.org/W1508985588","https://openalex.org/W1518689009","https://openalex.org/W1527972786","https://openalex.org/W1543868019","https://openalex.org/W1555027860","https://openalex.org/W1557101715","https://openalex.org/W1559667769","https://openalex.org/W1577972870","https://openalex.org/W1595251815","https://openalex.org/W1602558772","https://openalex.org/W1603605751","https://openalex.org/W1605596740","https://openalex.org/W1608179011","https://openalex.org/W1804433231","https://openalex.org/W1864995317","https://openalex.org/W1900087388","https://openalex.org/W1912580359","https://openalex.org/W1964615713","https://openalex.org/W1977104259","https://openalex.org/W1981958843","https://openalex.org/W1986192837","https://openalex.org/W1986347937","https://openalex.org/W1993385690","https://openalex.org/W1997029691","https://openalex.org/W1999377301","https://openalex.org/W1999843368","https://openalex.org/W2006331491","https://openalex.org/W2006363658","https://openalex.org/W2012768252","https://openalex.org/W2023126790","https://openalex.org/W2023334953","https://openalex.org/W2023397820","https://openalex.org/W2024827342","https://openalex.org/W2025014808","https://openalex.org/W2027738088","https://openalex.org/W2030365670","https://openalex.org/W2037379301","https://openalex.org/W2039903188","https://openalex.org/W2041237913","https://openalex.org/W2042103448","https://openalex.org/W2048317517","https://openalex.org/W2049592947","https://openalex.org/W2049633694","https://openalex.org/W2050097906","https://openalex.org/W2051454092","https://openalex.org/W2059543915","https://openalex.org/W2066751658","https://openalex.org/W2070134384","https://openalex.org/W2071880067","https://openalex.org/W2072035915","https://openalex.org/W2073594691","https://openalex.org/W2073917725","https://openalex.org/W2074331928","https://openalex.org/W2074891952","https://openalex.org/W2080043654","https://openalex.org/W2081727941","https://openalex.org/W2082760099","https://openalex.org/W2087311380","https://openalex.org/W2094038255","https://openalex.org/W2094562057","https://openalex.org/W2095901797","https://openalex.org/W2096007233","https://openalex.org/W2096486374","https://openalex.org/W2098101378","https://openalex.org/W2098641743","https://openalex.org/W2107871825","https://openalex.org/W2108421907","https://openalex.org/W2109085886","https://openalex.org/W2111648895","https://openalex.org/W2113218577","https://openalex.org/W2122719196","https://openalex.org/W2123869079","https://openalex.org/W2124910053","https://openalex.org/W2139566265","https://openalex.org/W2144726069","https://openalex.org/W2145185240","https://openalex.org/W2146888035","https://openalex.org/W2152551243","https://openalex.org/W2157359283","https://openalex.org/W2163285329","https://openalex.org/W2169556112","https://openalex.org/W2170343590","https://openalex.org/W2296941683","https://openalex.org/W2301837212","https://openalex.org/W2322147732","https://openalex.org/W2424197052","https://openalex.org/W4301412791"],"related_works":["https://openalex.org/W1492162135","https://openalex.org/W1555027860","https://openalex.org/W2139566265","https://openalex.org/W1977841569","https://openalex.org/W7098783333","https://openalex.org/W2018362256","https://openalex.org/W7099687256","https://openalex.org/W2415799338","https://openalex.org/W1484562168","https://openalex.org/W2076551734"],"abstract_inverted_index":{"Identification":[0],"of":[1,7,11,31,38,85,98,117,137,202,224,341,356],"disease":[2,143,178],"susceptibility":[3],"genes":[4],"is":[5,153,183],"one":[6],"the":[8,16,41,52,65,75,94,127,131,138,149,156,165,195,200,235,240,249,265,304,308,312,339,342,358],"primary":[9],"aims":[10],"contemporary":[12],"genetic":[13],"research.":[14],"With":[15],"recent":[17],"development":[18],"in":[19,126,215,222,260,282],"molecular":[20],"biology":[21],"techniques,":[22],"large-scale":[23],"gene":[24],"mapping":[25,287],"with":[26,68],"a":[27,34,176],"dense":[28],"genome-spanning":[29],"set":[30],"markers":[32,39],"becomes":[33],"reality.":[35],"The":[36,106],"availability":[37],"throughout":[40],"genome":[42],"has":[43],"made":[44],"linkage":[45,58,70,270,272],"and":[46,59,62,71,133,160,209,219,239,271,289,300,307,311],"association":[47,60,72],"studies":[48],"more":[49],"feasible.":[50],"In":[51,74,194,264],"first":[53,257],"chapter,":[54,77,197,267],"we":[55,78,198,268,324,336],"review":[56],"many":[57],"methods":[61],"point":[63],"out":[64],"potential":[66],"problems":[67],"current":[69],"analysis.":[73],"second":[76],"modify":[79],"two":[80,231,241,330],"identity-by-state":[81],"(IBS)":[82],"test":[83,91,167],"statistics":[84,168],"Lange":[86,103],"(Lange":[87],"K.":[88,104],"1986a,":[89],"A":[90],"statistic":[92],"for":[93,124,181,188,252,276],"affected-sib-set":[95],"method.":[96],"Annals":[97],"Human":[99,118],"Genetics":[100,119],"50,":[101],"283--290;":[102],"1986b,":[105],"affected":[107,203,253],"sib-pair":[108],"method":[109],"using":[110,145,279,316],"identity":[111,236],"by":[112],"descent":[113],"relations.":[114],"American":[115],"Journal":[116],"39,":[120],"148--150.)":[121],"to":[122,191,285,328],"allow":[123],"inbreeding":[125,151,182],"population.":[128,263],"We":[129,229,247,294],"evaluate":[130],"power":[132,161,172],"false":[134,157,291],"positive":[135,158,292],"rates":[136,159],"modified":[139,166],"tests":[140],"under":[141,175],"three":[142],"models":[144],"simulated":[146],"data.":[147],"When":[148],"population":[150,218],"coefficient":[152],"large,":[154],"both":[155],"are":[162],"reduced":[163],"when":[164],"were":[169],"applied,":[170],"although":[171],"remained":[173],"high":[174],"recessive":[177],"model.":[179],"Allowing":[180],"therefore":[184],"appropriate":[185],"at":[186],"least":[187],"diseases":[189],"known":[190],"be":[192],"recessive.":[193],"third":[196],"compute":[199],"proportions":[201],"sib":[204,254],"pairs":[205,255],"sharing":[206],"0,":[207],"1":[208],"2":[210],"marker":[211,305,331],"alleles":[212],"identity-by-decent":[213],"(IBD)":[214],"an":[216,261,283,317],"inbred":[217,262],"express":[220],"them":[221],"terms":[223],"higher":[225],"order":[226],"decent":[227],"measures.":[228],"perform":[230],"consistency":[232,242],"checks":[233,243],"on":[234],"state":[237],"probabilities":[238],"verify":[244],"our":[245,326,349],"calculations.":[246],"did":[248],"same":[250],"thing":[251],"from":[256],"cousin":[258],"marriage":[259],"fourth":[266],"study":[269,329],"disequilibrium":[273],"(LD)":[274],"simultaneously":[275,333],"single":[277,322],"QTL":[278,296,309,313],"family":[280],"data":[281],"attempt":[284],"increase":[286,338],"resolution":[288],"reduce":[290],"rates.":[293],"estimate":[295],"allele":[297],"frequencies,":[298],"LD":[299],"recombination":[301],"factions":[302],"between":[303],"loci":[306,332],"locus":[310],"model":[314,327],"parameters":[315,359],"EM":[318,350],"algorithm.":[319],"After":[320],"performing":[321],"analysis,":[323],"extend":[325],"so":[334],"that":[335,348],"can":[337,352],"accuracy":[340],"estimations.":[343],"Our":[344],"simulation":[345],"results":[346],"show":[347],"algorithm":[351],"give":[353],"consistent":[354],"estimates":[355],"all":[357],"considered.":[360]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-07-22T00:00:00"}
