{"id":"https://openalex.org/W2465638754","doi":"https://doi.org/10.1007/s00401-016-1595-4","title":"High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia","display_name":"High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia","publication_year":2016,"publication_date":"2016-07-08","ids":{"openalex":"https://openalex.org/W2465638754","doi":"https://doi.org/10.1007/s00401-016-1595-4","mag":"2465638754","pmid":"https://pubmed.ncbi.nlm.nih.gov/27393312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4992033"},"language":"en","primary_location":{"id":"doi:10.1007/s00401-016-1595-4","doi":"https://doi.org/10.1007/s00401-016-1595-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00401-016-1595-4","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00401-016-1595-4.pdf","source":{"id":"https://openalex.org/S198620474","display_name":"Acta Neuropathologica","issn_l":"0001-6322","issn":["0001-6322","1432-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs00401-016-1595-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071509158","display_name":"Caroline Baufeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Caroline Baufeld","raw_affiliation_strings":["Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","Department of Neuropathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neuropathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013785948","display_name":"Anja Osterloh","orcid":"https://orcid.org/0000-0003-3554-8108","observed_orcids":["https://orcid.org/0000-0003-3554-8108"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja Osterloh","raw_affiliation_strings":["Department of Neuropathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088006102","display_name":"Stefan Prokop","orcid":"https://orcid.org/0000-0002-5633-2149","observed_orcids":["https://orcid.org/0000-0002-5633-2149"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Stefan Prokop","raw_affiliation_strings":["Department of Neuropathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany","Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112359717","display_name":"Kelly R. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Kelly R. Miller","raw_affiliation_strings":["Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Neuropathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Neuropathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083257675","display_name":"Frank L. Heppner","orcid":"https://orcid.org/0000-0001-9816-8917","observed_orcids":["https://orcid.org/0000-0001-9816-8917"]},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4405268531","display_name":"NeuroCure Cluster of Excellence","ror":"https://ror.org/0188nsq50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268531"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frank L. Heppner","raw_affiliation_strings":["Berlin Institute of Health (BIH), Berlin, Germany. frank.heppner@charite.de","Cluster of Excellence, NeuroCure, Charit\u00e9platz 1, 10117, Berlin, Germany. frank.heppner@charite.de","Department of Neuropathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany. frank.heppner@charite.de","Cluster of Excellence, NeuroCure, Charit\u00e9platz 1, 10117, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9816-8917","affiliations":[{"raw_affiliation_string":"Berlin Institute of Health (BIH), Berlin, Germany. frank.heppner@charite.de","institution_ids":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Cluster of Excellence, NeuroCure, Charit\u00e9platz 1, 10117, Berlin, Germany. frank.heppner@charite.de","institution_ids":["https://openalex.org/I4405268531","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Neuropathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany. frank.heppner@charite.de","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Cluster of Excellence, NeuroCure, Charit\u00e9platz 1, 10117, Berlin, Germany","institution_ids":["https://openalex.org/I4405268531"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5083257675"],"corresponding_institution_ids":["https://openalex.org/I4210139777","https://openalex.org/I4405268531","https://openalex.org/I7877124"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":7.7194,"has_fulltext":true,"cited_by_count":230,"citation_normalized_percentile":{"value":0.9843923,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"132","issue":"3","first_page":"361","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9819999933242798},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.984000027179718},{"id":"https://openalex.org/keywords/gliosis","display_name":"gliosis","score":0.753000020980835},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.7910000085830688},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.38600000739097595},{"id":"https://openalex.org/keywords/anti-inflammatory-response","display_name":"anti-inflammatory response","score":0.7179999947547913},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7940000295639038},{"id":"https://openalex.org/keywords/microglial-gene-expression","display_name":"microglial gene expression","score":0.7300000190734863},{"id":"https://openalex.org/keywords/lipopolysaccharide-response","display_name":"lipopolysaccharide response","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.9684451818466187},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.6192066669464111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.610808789730072},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.551340639591217},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5070984363555908},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4941723644733429},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4577850103378296},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.45500704646110535},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4549543261528015},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4467945396900177},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4355294108390808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3901951313018799},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3055093288421631},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24094653129577637},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18602648377418518}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000821","descriptor_name":"Animal Feed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00401-016-1595-4","doi":"https://doi.org/10.1007/s00401-016-1595-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00401-016-1595-4","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00401-016-1595-4.pdf","source":{"id":"https://openalex.org/S198620474","display_name":"Acta Neuropathologica","issn_l":"0001-6322","issn":["0001-6322","1432-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4992033","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4992033","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathol","raw_type":"Text"},{"id":"pmid:27393312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27393312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neuropathologica","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/29407605","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:29407605","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00401-016-1595-4","doi":"https://doi.org/10.1007/s00401-016-1595-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00401-016-1595-4","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00401-016-1595-4.pdf","source":{"id":"https://openalex.org/S198620474","display_name":"Acta Neuropathologica","issn_l":"0001-6322","issn":["0001-6322","1432-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1657632943","display_name":null,"funder_award_id":"SFB TRR 43","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G211726408","display_name":null,"funder_award_id":"NeuroCure EXC257","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3584538239","display_name":null,"funder_award_id":"EXC257","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4879419993","display_name":null,"funder_award_id":"HE 3130/6\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320329666","display_name":"Berlin Institute of Health","ror":"https://ror.org/0493xsw21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2465638754.pdf","grobid_xml":"https://content.openalex.org/works/W2465638754.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1508215685","https://openalex.org/W1511961767","https://openalex.org/W1585782290","https://openalex.org/W1622777525","https://openalex.org/W1955666311","https://openalex.org/W1974799435","https://openalex.org/W1978567629","https://openalex.org/W1982080687","https://openalex.org/W1998451170","https://openalex.org/W2000054651","https://openalex.org/W2008869160","https://openalex.org/W2012730798","https://openalex.org/W2013543828","https://openalex.org/W2029190354","https://openalex.org/W2040153748","https://openalex.org/W2047021244","https://openalex.org/W2059996790","https://openalex.org/W2067875627","https://openalex.org/W2069968910","https://openalex.org/W2072210142","https://openalex.org/W2076633494","https://openalex.org/W2077033935","https://openalex.org/W2086237072","https://openalex.org/W2087133453","https://openalex.org/W2096500024","https://openalex.org/W2124836944","https://openalex.org/W2125125094","https://openalex.org/W2129316761","https://openalex.org/W2132924600","https://openalex.org/W2139778190","https://openalex.org/W2142272708","https://openalex.org/W2149347131","https://openalex.org/W2154696002","https://openalex.org/W2155702815","https://openalex.org/W2156796753","https://openalex.org/W2156821568","https://openalex.org/W2159619745","https://openalex.org/W2163410184","https://openalex.org/W2165707196","https://openalex.org/W2169342042","https://openalex.org/W2334337188","https://openalex.org/W2525939840","https://openalex.org/W4211216239"],"related_works":["https://openalex.org/W2574861159","https://openalex.org/W6927569514","https://openalex.org/W3042514097","https://openalex.org/W3132587494","https://openalex.org/W3013342059","https://openalex.org/W3030824581","https://openalex.org/W3167811625","https://openalex.org/W3025209623","https://openalex.org/W4396237584","https://openalex.org/W2109357385"],"abstract_inverted_index":{"Diets":[0],"high":[1,75,268],"in":[2,12,56,76,78,115,125,177,186,196,228,241,269,271,275,280,301],"fat":[3,77,270],"(HFD)":[4],"are":[5,35],"known":[6],"to":[7,37,54,73,141,144,159,175,239,249,251,266,297],"cause":[8],"an":[9,194,202],"immune":[10,27,46],"response":[11,28,72,174,284],"the":[13,18,38,44,49,57,67,70,84,126,136,182,187,229,246,261,302],"periphery":[14],"as":[15,17,179,277,279,288],"well":[16,278],"central":[19],"nervous":[20],"system.":[21],"In":[22],"peripheral":[23],"adipose":[24],"tissue,":[25],"this":[26,214,283],"is":[29,290],"primarily":[30],"mediated":[31,149],"by":[32,101,150,193,201],"macrophages":[33],"that":[34,234,263],"recruited":[36],"tissue.":[39],"Similarly,":[40],"reactivity":[41],"of":[42,48,59,69,87,90,122,131,163,208,221,237],"microglia,":[43],"innate":[45],"cells":[47,118],"brain,":[50],"has":[51],"been":[52],"shown":[53],"occur":[55],"hypothalamus":[58,127,189],"mice":[60,91],"fed":[61,92],"a":[62,79,112,120,171,219,272],"high-fat":[63,93],"diet.":[64],"To":[65],"characterize":[66],"nature":[68],"microglial":[71],"diets":[74,267],"temporal":[80],"fashion,":[81],"we":[82,110,134,232],"studied":[83],"phenotypic":[85],"spectrum":[86],"hypothalamic":[88,137,164],"microglia":[89,146,168,173,210,222,238,264,300],"diet":[94,176],"for":[95,225],"3":[96],"days":[97],"and":[98,106,119,147,166],"8":[99,129],"weeks":[100,130],"assessing":[102],"their":[103],"tissue":[104],"reaction":[105,121,140,184],"inflammatory":[107],"signature.":[108],"While":[109],"observed":[111],"significant":[113],"increase":[114,195],"Iba1+":[116],"myeloid":[117,138,152],"GFAP+":[123],"astrocytes":[124],"after":[128],"HFD":[132,240,298],"feeding,":[133],"found":[135,158],"cell":[139],"be":[142],"limited":[143],"endogenous":[145],"not":[148,191,211,244,291],"infiltrating":[151],"cells.":[153],"Moreover,":[154],"obese":[155],"humans":[156,178],"were":[157],"present":[160],"with":[161],"signs":[162],"gliosis":[165],"exacerbated":[167],"dystrophy,":[169],"suggesting":[170],"targeted":[172],"well.":[180],"Notably,":[181],"glial":[183],"occurring":[185],"mouse":[188],"was":[190],"accompanied":[192],"pro-inflammatory":[197,293],"cytokines,":[198],"but":[199,216],"rather":[200],"anti-inflammatory":[203],"reaction.":[204],"Gene":[205],"expression":[206],"analyses":[207],"isolated":[209],"only":[212],"confirmed":[213],"observation,":[215],"also":[217],"revealed":[218],"downregulation":[220],"genes":[223],"important":[224],"sensing":[226],"signals":[227],"microenvironment.":[230],"Finally,":[231],"demonstrate":[233],"long-term":[235],"exposure":[236,296],"vivo":[242],"does":[243,295],"impair":[245],"cell's":[247],"ability":[248],"respond":[250],"additional":[252],"stimuli,":[253],"like":[254],"lipopolysaccharide.":[255],"Taken":[256],"together,":[257],"our":[258],"findings":[259],"support":[260],"notion":[262],"react":[265],"region-specific":[273],"manner":[274],"rodents":[276],"humans;":[281],"however,":[282],"changes":[285],"over":[286],"time":[287],"it":[289],"exclusively":[292],"nor":[294],"prime":[299],"hypothalamus.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":45},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}