{"id":"https://openalex.org/W2465521091","doi":null,"title":"Structural inferences of the ETS1 DNA-binding domain determined by mutational analysis.","display_name":"Structural inferences of the ETS1 DNA-binding domain determined by mutational analysis.","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W2465521091","mag":"2465521091","pmid":"https://pubmed.ncbi.nlm.nih.gov/8290254"},"language":"en","primary_location":{"id":"pmid:8290254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8290254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074589649","display_name":"George Mavrothalassitis","orcid":"https://orcid.org/0000-0001-6214-3179","observed_orcids":["https://orcid.org/0000-0001-6214-3179"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Mavrothalassitis","raw_affiliation_strings":["Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21702-1201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21702-1201","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035537529","display_name":"Robert J. Fisher","orcid":"https://orcid.org/0000-0003-4598-2274","observed_orcids":["https://orcid.org/0000-0003-4598-2274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Fisher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038044937","display_name":"FE Smyth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Smyth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069635194","display_name":"D K Watson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D K Watson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110119108","display_name":"T S Papas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T S Papas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1678,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.78073177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"2","first_page":"425","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.3244999945163727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ets-transcription-factors","display_name":"ETS transcription factors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dna-binding-domain","display_name":"DNA-binding domain","score":0.9869999885559082},{"id":"https://openalex.org/keywords/basic-region","display_name":"basic region","score":0.6420000195503235},{"id":"https://openalex.org/keywords/sequence-specific-dna-recognition","display_name":"sequence-specific DNA recognition","score":0.7770000100135803},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6679999828338623},{"id":"https://openalex.org/keywords/transactivation-activity","display_name":"transactivation activity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/conserved-domains","display_name":"conserved domains","score":0.6389999985694885},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7745152711868286},{"id":"https://openalex.org/C33987129","wikidata":"https://www.wikidata.org/wiki/Q13479514","display_name":"DNA-binding domain","level":4,"score":0.6270392537117004},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.6034919023513794},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5622572302818298},{"id":"https://openalex.org/C5179208","wikidata":"https://www.wikidata.org/wiki/Q3782057","display_name":"HMG-box","level":5,"score":0.5092655420303345},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5004851818084717},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4736382067203522},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.4695841670036316},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.46919888257980347},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4514622986316681},{"id":"https://openalex.org/C156569929","wikidata":"https://www.wikidata.org/wiki/Q24723866","display_name":"B3 domain","level":5,"score":0.45084598660469055},{"id":"https://openalex.org/C19408993","wikidata":"https://www.wikidata.org/wiki/Q24784063","display_name":"bZIP domain","level":5,"score":0.4470144808292389},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4216685891151428},{"id":"https://openalex.org/C199487717","wikidata":"https://www.wikidata.org/wiki/Q24786260","display_name":"Helix-turn-helix","level":5,"score":0.41820281744003296},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41292449831962585},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.3823193609714508},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2417108118534088},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.20671743154525757},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11207354068756104}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050783","descriptor_name":"Proto-Oncogene Proteins c-ets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050784","descriptor_name":"Proto-Oncogene Protein c-ets-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8290254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8290254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:2465521091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8290254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1526458434","https://openalex.org/W2146886804","https://openalex.org/W2064017844","https://openalex.org/W2043930487","https://openalex.org/W2108820065","https://openalex.org/W1981888736","https://openalex.org/W2342275145","https://openalex.org/W2054205310","https://openalex.org/W13853719","https://openalex.org/W1985173600"],"abstract_inverted_index":{"The":[0],"ets":[1,236],"family":[2],"of":[3,35,39,85,107,121,153,173,202,234],"transcription":[4],"factors":[5],"is":[6,89,112,176,208,226],"characterized":[7],"by":[8],"a":[9,65,75,195],"conserved":[10,53],"region":[11,54,106,131,146,201],"that":[12,45,82,138,166,207,218],"harbors":[13],"the":[14,33,36,40,49,70,86,104,108,144,154,167,199,203,219,235],"DNA-binding":[15,37,62,163],"activity.":[16,182],"We":[17,43,215],"performed":[18],"extensive":[19],"deletion":[20],"and":[21,126,232],"mutational":[22,184],"analyses,":[23],"as":[24,26,96,98,186,188],"well":[25,187],"DNA-peptide":[27],"interaction":[28],"studies":[29],"necessary":[30,90],"to":[31,59,114,133,177,193,210],"identify":[32],"determinants":[34],"activity":[38,63,152],"ETS1":[41,109,155,204],"oncoprotein.":[42],"found":[44],"amino":[46,51,141],"acids":[47,142],"beyond":[48],"85":[50],"acid":[52],"are":[55,147],"required":[56,148],"in":[57,64],"order":[58],"afford":[60],"maximum":[61],"heterologous":[66],"system.":[67],"Mutation":[68],"throughout":[69],"binding":[71,79,110,205,237],"domain":[72,88,175,206],"can":[73],"have":[74],"detrimental":[76],"effect":[77],"on":[78],"activity,":[80,164],"indicating":[81,137,165],"proper":[83,229],"folding":[84,231],"entire":[87],"for":[91,149,198,228],"DNA":[92,117,180],"binding.":[93,150],"A":[94],"peptide,":[95],"small":[97],"37":[99],"residues":[100],"(K37N),":[101],"derived":[102],"from":[103],"basic":[105,145,200],"domain,":[111],"sufficient":[113],"exhibit":[115],"sequence-specific":[116,179],"recognition.":[118],"Total":[119],"randomization":[120],"Lysine":[122,124],"379,":[123],"381":[125],"Arginine":[127],"391":[128],"within":[129,143],"this":[130,174],"fails":[132],"provide":[134,178],"functional":[135],"substitutions,":[136],"these":[139],"specific":[140],"Transactivation":[151],"proteins":[156],"bearing":[157],"mutations":[158],"was":[159],"consistent":[160],"with":[161,213],"their":[162],"primary":[168],"(if":[169],"not":[170],"only)":[171],"function":[172],"recognition":[181],"Our":[183],"analysis,":[185],"modeling":[189],"predictions,":[190],"lead":[191],"us":[192],"propose":[194,217],"helix-turn-helix":[196],"structure":[197],"able":[209],"interact":[211],"directly":[212],"DNA.":[214],"also":[216],"hydrophobic":[220],"alpha-helical":[221],"region,":[222],"surrounding":[223],"tryptophan":[224],"338,":[225],"fundamental":[227],"protein":[230],"functioning":[233],"domain.":[238]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}