{"id":"https://openalex.org/W2465474902","doi":null,"title":"[Development of antisense nucleotides for therapy].","display_name":"[Development of antisense nucleotides for therapy].","publication_year":2006,"publication_date":"2006-02-01","ids":{"openalex":"https://openalex.org/W2465474902","mag":"2465474902","pmid":"https://pubmed.ncbi.nlm.nih.gov/16532848"},"language":"zh","primary_location":{"id":"pmid:16532848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16532848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044152423","display_name":"Ju Wang","orcid":"https://orcid.org/0000-0002-9684-4288","observed_orcids":["https://orcid.org/0000-0002-9684-4288"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ju Wang","raw_affiliation_strings":["Department of General Surgery, The First Hospital of Jilin University, Changchun 130021, China. wangju_86@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The First Hospital of Jilin University, Changchun 130021, China. wangju_86@163.com","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lei Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103001763","display_name":"Youde Wang","orcid":"https://orcid.org/0000-0001-6422-3543","observed_orcids":["https://orcid.org/0000-0001-6422-3543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youde Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24885607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"1","first_page":"230","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.2215999960899353,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.996999979019165},{"id":"https://openalex.org/keywords/antisense-therapy","display_name":"antisense therapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/gene-expression-inhibition","display_name":"gene expression inhibition","score":0.828000009059906},{"id":"https://openalex.org/keywords/antisense-drug-development","display_name":"antisense drug development","score":0.7170000076293945},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.7790305614471436},{"id":"https://openalex.org/C2908938912","wikidata":"https://www.wikidata.org/wiki/Q4067124","display_name":"Antisense therapy","level":5,"score":0.7717558145523071},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.682202935218811},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6306617856025696},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.591652512550354},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5588194131851196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5452374815940857},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5376817584037781},{"id":"https://openalex.org/C202416437","wikidata":"https://www.wikidata.org/wiki/Q423832","display_name":"Antisense RNA","level":4,"score":0.49944210052490234},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49519672989845276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4398963153362274},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3242604732513428},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26086413860321045},{"id":"https://openalex.org/C14363569","wikidata":"https://www.wikidata.org/wiki/Q418639","display_name":"Locked nucleic acid","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16532848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16532848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi","raw_type":"English Abstract"},{"id":"mag:2465474902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16532848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2429923729","https://openalex.org/W3216095951","https://openalex.org/W1974957637","https://openalex.org/W2439834355","https://openalex.org/W71656912","https://openalex.org/W2051192216","https://openalex.org/W4396986127","https://openalex.org/W7007634191","https://openalex.org/W625557250","https://openalex.org/W2993177574"],"abstract_inverted_index":{"Antisense":[0],"oligonucleotides":[1,57],"(ASODN)":[2],"for":[3,36],"therapy":[4],"is":[5,10,23],"a":[6,61],"genetic":[7,65],"technology":[8],"which":[9],"based":[11],"on":[12],"the":[13,26,38,78,88,93],"base-complementary":[14],"principle.":[15],"DNA":[16],"or":[17,32],"RNA":[18],"sequence":[19],"synthesized":[20],"by":[21],"biotechnology":[22],"transferred":[24],"into":[25],"target":[27,41],"cells":[28],"to":[29],"form":[30],"mRNA-DNA":[31],"mRNA-RNA":[33],"double":[34],"strand":[35],"inhibiting":[37],"expression":[39],"of":[40,55,64,80],"genes.":[42],"In":[43],"this":[44],"way":[45],"we":[46,91],"can":[47],"control":[48],"and":[49,73,84],"treat":[50],"some":[51],"diseases.":[52,86],"The":[53],"development":[54],"antisense":[56],"drugs":[58],"has":[59],"opened":[60],"new":[62],"area":[63],"pharmacology.":[66],"This":[67],"paper":[68],"reviews":[69],"its":[70,74],"classifications,":[71],"mechanics":[72],"wide":[75],"application":[76],"in":[77],"treatment":[79],"viral":[81],"infection,":[82],"tumor":[83],"cardiovascular":[85],"At":[87],"same":[89],"time":[90],"pose":[92],"problems":[94],"that":[95],"need":[96],"solving.":[97]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-07-22T00:00:00"}
