{"id":"https://openalex.org/W2465060140","doi":null,"title":"IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.","display_name":"IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.","publication_year":1995,"publication_date":"1995-08-03","ids":{"openalex":"https://openalex.org/W2465060140","mag":"2465060140","pmid":"https://pubmed.ncbi.nlm.nih.gov/7543195"},"language":"en","primary_location":{"id":"pmid:7543195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7543195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S Kirchhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Kirchhoff","raw_affiliation_strings":["GBF--Gesellschaft f\u00fcr Biotechnologische Forschung mbH, Braunschweig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GBF--Gesellschaft f\u00fcr Biotechnologische Forschung mbH, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210124929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002284937","display_name":"Antonis E. Koromilas","orcid":"https://orcid.org/0000-0003-1972-0799","observed_orcids":["https://orcid.org/0000-0003-1972-0799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A E Koromilas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075721841","display_name":"Fred Schaper","orcid":"https://orcid.org/0000-0002-8899-5414","observed_orcids":["https://orcid.org/0000-0002-8899-5414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Schaper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061655234","display_name":"Martina Grashoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Grashoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019957951","display_name":"Nahum Sonenberg","orcid":"https://orcid.org/0000-0002-4707-8759","observed_orcids":["https://orcid.org/0000-0002-4707-8759"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Sonenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091704443","display_name":"H. H\u00e4user","orcid":"https://orcid.org/0000-0002-4418-9859","observed_orcids":["https://orcid.org/0000-0002-4418-9859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Hauser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7812,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.9146856,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"11","issue":"3","first_page":"439","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irf-1","display_name":"IRF1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/protein-kinase-pkr","display_name":"protein kinase PKR","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.8429999947547913},{"id":"https://openalex.org/keywords/interferon-beta-induction","display_name":"interferon-beta induction","score":0.734000027179718},{"id":"https://openalex.org/keywords/tumor-suppressor-activity","display_name":"tumor suppressor activity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/serine-threonine-kinase","display_name":"serine/threonine kinase","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C161238802","wikidata":"https://www.wikidata.org/wiki/Q14905690","display_name":"Protein kinase R","level":5,"score":0.8994380235671997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8090689182281494},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.7157778143882751},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5974308252334595},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5805791616439819},{"id":"https://openalex.org/C2777479484","wikidata":"https://www.wikidata.org/wiki/Q5323131","display_name":"EIF-2 kinase","level":5,"score":0.5455015897750854},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5205293893814087},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.464641809463501},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4448881149291992},{"id":"https://openalex.org/C32300475","wikidata":"https://www.wikidata.org/wiki/Q18027992","display_name":"IRF1","level":4,"score":0.44012778997421265},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43124476075172424},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41754770278930664},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3797554671764374},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.32193928956985474},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.2759326994419098},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25650322437286377},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.23150205612182617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1928112506866455},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16086345911026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12854638695716858}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050856","descriptor_name":"Interferon Regulatory Factor-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7543195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7543195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:2465060140","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7543195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2414538832","https://openalex.org/W2333639788","https://openalex.org/W2077808289","https://openalex.org/W1981964452","https://openalex.org/W1970812281","https://openalex.org/W2071495961","https://openalex.org/W7038124614","https://openalex.org/W2018898580","https://openalex.org/W7096537462","https://openalex.org/W2163476769"],"abstract_inverted_index":{"Expression":[0],"of":[1,10,16,38,43,77,87],"the":[2,8,17,26,39,83],"tumor":[3,52,84],"suppressor":[4,53,85],"IRF-1":[5,27,40,55,88],"results":[6],"in":[7,93],"inhibition":[9,59],"cell":[11,29,57],"growth":[12,30,58],"and":[13,60],"transcriptional":[14],"activation":[15,37],"IFN-beta":[18],"gene.":[19],"IFN":[20,61],"production":[21],"is":[22,33,47,89],"not":[23],"responsible":[24],"for":[25],"mediated":[28,56],"inhibition.":[31],"It":[32],"shown":[34],"here":[35],"that":[36,82],"causes":[41],"induction":[42,62],"PKR":[44,46,65,72],"expression.":[45,66],"a":[48],"serine/threonine":[49],"kinase":[50],"with":[51,64],"activity.":[54],"correlates":[63],"A":[67],"catalytically":[68],"inactive":[69],"dominant":[70],"negative":[71],"mutant":[73],"abolishes":[74],"both":[75],"activities":[76],"IRF-1.":[78],"These":[79],"data":[80],"demonstrate":[81],"activity":[86],"mediated,":[90],"at":[91],"least":[92],"part,":[94],"by":[95],"PKR.":[96]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}