{"id":"https://openalex.org/W2465028554","doi":null,"title":"[FGF23 and the heart].","display_name":"[FGF23 and the heart].","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2465028554","mag":"2465028554","pmid":"https://pubmed.ncbi.nlm.nih.gov/25504170","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6350534"},"language":"it","primary_location":{"id":"pmid:25504170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25504170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6350534","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060234485","display_name":"Ikenna I. Ezumba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Ezumba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028902678","display_name":"L. Darryl Quarles","orcid":"https://orcid.org/0000-0002-5082-7896","observed_orcids":["https://orcid.org/0000-0002-5082-7896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L D Quarles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074587712","display_name":"Csaba Pal Kovesdy","orcid":"https://orcid.org/0000-0002-8204-911X","observed_orcids":["https://orcid.org/0000-0002-8204-911X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C P Kovesdy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1423,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.12936733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"31","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.972000002861023},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.8209999799728394},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/mineral-and-bone-disorder","display_name":"mineral and bone disorder","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.8190000057220459},{"id":"https://openalex.org/keywords/pathophysiological-pathways","display_name":"pathophysiological pathways","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8483302593231201},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.7429429292678833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.692294716835022},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6703864336013794},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6374326944351196},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6138423085212708},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5294886231422424},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5253374576568604},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.5221415162086487},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4980194568634033},{"id":"https://openalex.org/C203857694","wikidata":"https://www.wikidata.org/wiki/Q5158344","display_name":"Concentric hypertrophy","level":4,"score":0.46394774317741394},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4605822265148163},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.4363787770271301},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2251042127609253},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15931367874145508},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:25504170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25504170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5330857","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6350534","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6350534","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6350534/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"G Ital Nefrol","raw_type":"Text"},{"id":"mag:2465028554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25504170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5330857","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6350534","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2586886983","display_name":"Regulation and Function of FGF23","funder_award_id":"R01AR045955","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W1964311752","https://openalex.org/W1964769443","https://openalex.org/W1967918805","https://openalex.org/W1971484061","https://openalex.org/W1971735000","https://openalex.org/W1972458772","https://openalex.org/W1973733126","https://openalex.org/W1974739160","https://openalex.org/W1975258397","https://openalex.org/W1976544899","https://openalex.org/W1977645780","https://openalex.org/W1978114446","https://openalex.org/W1979425916","https://openalex.org/W1979749207","https://openalex.org/W1983098935","https://openalex.org/W1984041554","https://openalex.org/W1987394548","https://openalex.org/W1988215184","https://openalex.org/W1989622420","https://openalex.org/W1993754429","https://openalex.org/W1996698106","https://openalex.org/W1996978408","https://openalex.org/W1999648128","https://openalex.org/W2000596634","https://openalex.org/W2001405719","https://openalex.org/W2001962405","https://openalex.org/W2003490678","https://openalex.org/W2007331929","https://openalex.org/W2011104926","https://openalex.org/W2011349880","https://openalex.org/W2011862587","https://openalex.org/W2013057766","https://openalex.org/W2013670186","https://openalex.org/W2015668150","https://openalex.org/W2017219647","https://openalex.org/W2019397580","https://openalex.org/W2020088730","https://openalex.org/W2023869058","https://openalex.org/W2027418334","https://openalex.org/W2033735075","https://openalex.org/W2037498463","https://openalex.org/W2043958868","https://openalex.org/W2050565170","https://openalex.org/W2051969301","https://openalex.org/W2053091007","https://openalex.org/W2054151200","https://openalex.org/W2055172928","https://openalex.org/W2056263872","https://openalex.org/W2058721308","https://openalex.org/W2059099969","https://openalex.org/W2060629558","https://openalex.org/W2060906962","https://openalex.org/W2061569406","https://openalex.org/W2064548125","https://openalex.org/W2068949553","https://openalex.org/W2073168952","https://openalex.org/W2077315258","https://openalex.org/W2078730571","https://openalex.org/W2082246696","https://openalex.org/W2085387237","https://openalex.org/W2086615343","https://openalex.org/W2086822373","https://openalex.org/W2089817491","https://openalex.org/W2091200828","https://openalex.org/W2093291689","https://openalex.org/W2094354621","https://openalex.org/W2094551185","https://openalex.org/W2095948376","https://openalex.org/W2098828778","https://openalex.org/W2100644178","https://openalex.org/W2103141097","https://openalex.org/W2106711282","https://openalex.org/W2107420262","https://openalex.org/W2107471648","https://openalex.org/W2108218799","https://openalex.org/W2108947052","https://openalex.org/W2111097992","https://openalex.org/W2111614075","https://openalex.org/W2111899789","https://openalex.org/W2114360920","https://openalex.org/W2114372930","https://openalex.org/W2118752987","https://openalex.org/W2119470206","https://openalex.org/W2119846536","https://openalex.org/W2120129493","https://openalex.org/W2120619511","https://openalex.org/W2121435915","https://openalex.org/W2122892477","https://openalex.org/W2125079553","https://openalex.org/W2125383113","https://openalex.org/W2125408889","https://openalex.org/W2127647640","https://openalex.org/W2128473811","https://openalex.org/W2128749750","https://openalex.org/W2129321769","https://openalex.org/W2131843552","https://openalex.org/W2132537604","https://openalex.org/W2135537978","https://openalex.org/W2137069121","https://openalex.org/W2137720344","https://openalex.org/W2138484848","https://openalex.org/W2140998775","https://openalex.org/W2141482249","https://openalex.org/W2143470199","https://openalex.org/W2144934728","https://openalex.org/W2146278956","https://openalex.org/W2147201241","https://openalex.org/W2148873853","https://openalex.org/W2152171089","https://openalex.org/W2153481494","https://openalex.org/W2154225761","https://openalex.org/W2155036045","https://openalex.org/W2156595626","https://openalex.org/W2157248652","https://openalex.org/W2157448600","https://openalex.org/W2159323221","https://openalex.org/W2159397492","https://openalex.org/W2162615269","https://openalex.org/W2164650897","https://openalex.org/W2166385931","https://openalex.org/W2167092665","https://openalex.org/W2167995070","https://openalex.org/W2168322307","https://openalex.org/W2170092490","https://openalex.org/W2170810459","https://openalex.org/W2170995361","https://openalex.org/W2270719279","https://openalex.org/W2475261460","https://openalex.org/W2527550773","https://openalex.org/W2586813559"],"related_works":["https://openalex.org/W1967664222","https://openalex.org/W2763090493","https://openalex.org/W7098650842","https://openalex.org/W7128744787","https://openalex.org/W2149362302","https://openalex.org/W1609377807","https://openalex.org/W2984646011","https://openalex.org/W2885939429","https://openalex.org/W2616973692","https://openalex.org/W2508823587"],"abstract_inverted_index":{"The":[0,110],"prevalence":[1,26,112],"of":[2,27,64,69,113,175,193,211,220,252],"chronic":[3,153,189],"kidney":[4,154,190],"disease":[5,42,46,74,162,267],"(CKD)":[6],"has":[7],"now":[8],"reached":[9],"epidemic":[10],"proportions":[11],"and":[12,32,44,93,131,142,167,197,243],"it":[13,18],"is":[14,36,52,85,102,119],"very":[15],"likely":[16],"that":[17,56,75],"will":[19],"continue":[20],"to":[21,49,71,121,129,135,233,262],"rise":[22],"with":[23,58,82,139,152,188,270],"the":[24,104,107,172,179,212,222,225,247,253],"increasing":[25],"juvenile":[28],"diabetes":[29],"mellitus,":[30],"hypertension":[31],"aging":[33],"population.":[34,109],"CKD":[35,59,118,194],"a":[37,61,86],"risk":[38,63,158,183],"factor":[39,205],"for":[40,160,258],"cardiovascular":[41,45,161,176,182,248,266],"(CVD)":[43],"can":[47],"lead":[48,232,261],"CKD.":[50,271],"It":[51],"also":[53],"well":[54],"known":[55],"patients":[57,81,151,187,269],"have":[60,147,208,240],"higher":[62,87],"death":[65,92],"from":[66,89,126],"CVD":[67,235],"than":[68,97],"progressing":[70],"end-stage":[72],"renal":[73,77],"requires":[76],"replacement":[78],"therapy.":[79],"In":[80],"CKD,":[83],"there":[84],"mortality":[88],"sudden":[90],"cardiac":[91,122],"congestive":[94,114],"heart":[95,115],"failure":[96,116],"coronary":[98],"artery":[99],"disease,":[100,155,191],"which":[101,124,200,229],"not":[103,170],"case":[105],"in":[106,117,150,186,268],"general":[108],"high":[111],"due":[120],"remodeling":[123,128],"progresses":[125],"concentric":[127,130],"eccentric":[132],"hypertrophy,":[133],"leading":[134],"left":[136],"ventricular":[137],"hypertrophy":[138],"both":[140,241],"systolic":[141],"diastolic":[143],"dysfunction.":[144],"Recent":[145],"studies":[146],"suggested":[148],"that,":[149],"common":[156],"traditional":[157],"factors":[159,184],"such":[163],"as":[164],"hypertension,":[165],"hyperlipidemia":[166],"obesity":[168],"may":[169,231,239,260],"be":[171],"main":[173],"determinants":[174],"disease.":[177],"Among":[178],"various":[180],"non-traditional":[181],"present":[185],"abnormalities":[192],"related":[195],"mineral":[196],"bone":[198],"disorder,":[199],"includes":[201],"elevated":[202],"fibroblast":[203],"growth":[204],"23":[206],"(FGF23)":[207],"been":[209],"one":[210],"most":[213,254],"extensively":[214],"studied.":[215],"However,":[216],"after":[217],"many":[218],"years":[219],"research,":[221],"debate":[223],"over":[224],"exact":[226],"pathways":[227,257],"by":[228],"FGF23":[230,238,259],"increased":[234],"still":[236],"continues.":[237],"direct":[242],"indirect":[244],"effects":[245],"on":[246],"system.":[249],"Better":[250],"understanding":[251],"relevant":[255],"pathophysiologic":[256],"therapeutic":[263],"interventions":[264],"against":[265]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-07-22T00:00:00"}