{"id":"https://openalex.org/W2465002136","doi":"https://doi.org/10.1183/13993003.congress-2015.pa4076","title":"Relationship of cold frequency and virus detection to exacerbations in COPD patients","display_name":"Relationship of cold frequency and virus detection to exacerbations in COPD patients","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2465002136","doi":"https://doi.org/10.1183/13993003.congress-2015.pa4076","mag":"2465002136"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2015.pa4076","doi":"https://doi.org/10.1183/13993003.congress-2015.pa4076","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2015.pa4076","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"6.1 Epidemiology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111371216","display_name":"Neil W. Johnston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Neil Johnston","raw_affiliation_strings":["Firestone Institute for Respiratory Health, McMaster University Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Firestone Institute for Respiratory Health, McMaster University Department of Medicine","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010019658","display_name":"Marita Olsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marita Olsson","raw_affiliation_strings":["Discovery Sciences, AstraZeneca R&D"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Sciences, AstraZeneca R&D","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111826482","display_name":"Staffan Edsb\u00e4cker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Staffan Edsbacker","raw_affiliation_strings":["Innovative Medicines Unit, AstraZeneca R&D"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovative Medicines Unit, AstraZeneca R&D","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055336852","display_name":"Maria Gerhardsson de Verdier","orcid":"https://orcid.org/0000-0002-4029-1215","observed_orcids":["https://orcid.org/0000-0002-4029-1215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Gerhardsson de Verdier","raw_affiliation_strings":["Observational Research Centre, AstraZeneca R&D"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Observational Research Centre, AstraZeneca R&D","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Per Gustafson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Per Gustafson","raw_affiliation_strings":["ECD RIA TMU, AstraZeneca R&D"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ECD RIA TMU, AstraZeneca R&D","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063703192","display_name":"Christopher McCrae","orcid":"https://orcid.org/0000-0001-7184-9069","observed_orcids":["https://orcid.org/0000-0001-7184-9069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher McCrae","raw_affiliation_strings":["Innovative Medicines Unit, AstraZeneca R&D"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovative Medicines Unit, AstraZeneca R&D","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043373594","display_name":"Andrew McIvor","orcid":"https://orcid.org/0000-0001-9411-0160","observed_orcids":["https://orcid.org/0000-0001-9411-0160"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew McIvor","raw_affiliation_strings":["Firestone Institute for Respiratory Health, McMaster University Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Firestone Institute for Respiratory Health, McMaster University Department of Medicine","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA4076","last_page":"PA4076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.6930000185966492},{"id":"https://openalex.org/keywords/acute-exacerbation","display_name":"acute exacerbation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/respiratory-viruses","display_name":"respiratory viruses","score":0.7379999756813049},{"id":"https://openalex.org/keywords/virus-detection","display_name":"virus detection","score":0.5519999861717224},{"id":"https://openalex.org/keywords/exacerbation-risk","display_name":"exacerbation risk","score":0.8040000200271606},{"id":"https://openalex.org/keywords/symptom-severity","display_name":"symptom severity","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sputum","display_name":"sputum","score":0.5849999785423279},{"id":"https://openalex.org/keywords/nasal-fluid","display_name":"nasal fluid","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9238103628158569},{"id":"https://openalex.org/C190729725","wikidata":"https://www.wikidata.org/wiki/Q5012817","display_name":"CLs upper limits","level":2,"score":0.7573617696762085},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6635892987251282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6334744691848755},{"id":"https://openalex.org/C73269764","wikidata":"https://www.wikidata.org/wiki/Q954529","display_name":"Poisson regression","level":3,"score":0.6130818128585815},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49027445912361145},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.4311607778072357},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.07290777564048767},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0721946656703949},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2015.pa4076","doi":"https://doi.org/10.1183/13993003.congress-2015.pa4076","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2015.pa4076","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"6.1 Epidemiology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2592039943","https://openalex.org/W2110265450","https://openalex.org/W4388410732","https://openalex.org/W4410889946","https://openalex.org/W1915599982","https://openalex.org/W2041341240","https://openalex.org/W4416635706","https://openalex.org/W147306992","https://openalex.org/W2906390882","https://openalex.org/W2529644354"],"abstract_inverted_index":{"Background:":[0],"Cold":[1],"frequency":[2],"is":[3],"positively":[4],"associated":[5,240],"with":[6,26,119,134,186,199,233,241,263],"risks":[7],"of":[8,95,132,144,167,236,245,269],"acute":[9],"exacerbations":[10],"(AE)":[11],"in":[12,23,88,92,113,211],"COPD.":[13],"We":[14],"measured":[15],"AE":[16,22,80,90,126,151,168,185,215,224,247],"risk":[17,152,166,244],"and":[18,27,63,72,248],"symptom":[19,114,191,251],"severity":[20,115,212,252],"during":[21,253],"COPD":[24,38,246,255],"patients":[25,39,256],"without":[28,146],"self-reported":[29],"cold-like":[30],"symptoms":[31],"(CLS).":[32],"Methods:":[33],"Forty-six":[34],"community-based":[35],"GOLD":[36],"1-4":[37],"transmitted":[40,53],"daily":[41],"health":[42],"diaries":[43,54],"by":[44],"fax":[45],"from":[46,57,65],"December":[47,58,66],"2006":[48],"to":[49,60,68,110,197,205],"April":[50,69],"2007,":[51],"50":[52],"using":[55,99],"BlackBerrys":[56],"2007":[59],"November":[61],"2008":[62,67],"71":[64],"2009.":[70],"Sputum":[71],"nasal":[73],"fluid":[74],"collection":[75],"for":[76,160,261],"virology":[77],"occurred":[78],"if":[79],"or":[81],"colds":[82],"were":[83,108,137,141,179],"suspected.":[84],"The":[85,148,207],"relative":[86],"increase":[87],"the":[89,93,189,234],"rate":[91],"presence":[94,235],"CLS":[96,136,162,178,187,201,217,238],"was":[97,169,193,218],"examined":[98],"a":[100,242,259],"Poisson":[101],"regression":[102],"model.":[103],"Generalised":[104],"estimating":[105],"equation":[106],"models":[107],"used":[109],"examine":[111],"differences":[112],"scores.":[116],"Results:":[117],"Compliance":[118],"diary":[120],"transmission":[121],"exceeded":[122],"95%.":[123],"Among":[124],"263":[125],"meeting":[127],"Anthonisen":[128],"criteria":[129],"79":[130],"(44%)":[131],"180":[133],"coincident":[135],"virus":[138,222,229],"positive,":[139],"as":[140],"26":[142],"(31%)":[143],"83":[145],"CLS.":[147,237,270],"population":[149],"mean":[150,209],"increased":[153,249],"1.3":[154],"times":[155,171],"(95%":[156,172],"CI":[157,173],"1.3,1.4":[158],"p<.001)":[159,175],"each":[161],"episode.":[163],"Within":[164],"subject":[165],"30":[170],"20,47":[174],"greater":[176],"when":[177,182],"present":[180,188],"than":[181],"not.":[183],"During":[184],"median":[190],"score":[192,213],"0.86":[194],"(range":[195,203],"-2.7":[196],"6.0),":[198],"no":[200],"0.29":[202],"-1.1":[204],"2.7).":[206],"estimated":[208],"difference":[210],"between":[214,221],"with/without":[216],"0.51":[219],"(p<0.001),":[220],"positive/negative":[223],"0.52":[225],"(p<0.001).":[226],"Conclusions:":[227],"Positive":[228],"testing":[230],"correlates":[231],"poorly":[232],"are":[239],"higher":[243],"respiratory":[250],"these.":[254],"should":[257],"be":[258],"priority":[260],"treatment":[262],"emerging":[264],"drugs":[265],"that":[266],"target":[267],"causes":[268]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}