{"id":"https://openalex.org/W2464974158","doi":null,"title":"Effect of airborne particulate extracts on monocyte oxidative metabolism.","display_name":"Effect of airborne particulate extracts on monocyte oxidative metabolism.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2464974158","mag":"2464974158","pmid":"https://pubmed.ncbi.nlm.nih.gov/9276001"},"language":"en","primary_location":{"id":"pmid:9276001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9276001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023183087","display_name":"Roberto Fabiani","orcid":"https://orcid.org/0000-0003-4865-9413","observed_orcids":["https://orcid.org/0000-0003-4865-9413"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Fabiani","raw_affiliation_strings":["Department of Cellular and Molecular Biology, University of Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Biology, University of Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017567144","display_name":"Lucia Pampanella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Pampanella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063914924","display_name":"Alba Minelli","orcid":"https://orcid.org/0000-0001-9560-9289","observed_orcids":["https://orcid.org/0000-0001-9560-9289"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Minelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006374661","display_name":"Isabella Mezzasoma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Mezzasoma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051777748","display_name":"Anna Vecchiarelli","orcid":"https://orcid.org/0000-0002-3185-6720","observed_orcids":["https://orcid.org/0000-0002-3185-6720"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Vecchiarelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086811765","display_name":"Giacomo Morozzi","orcid":"https://orcid.org/0009-0005-3361-7810","observed_orcids":["https://orcid.org/0009-0005-3361-7810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Morozzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.29893393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"2-3","first_page":"195","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.24230000376701355,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airborne-particulate-matter","display_name":"airborne particulate matter","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/oxidative-metabolism","display_name":"oxidative metabolism","score":0.7239999771118164},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.7329999804496765},{"id":"https://openalex.org/keywords/respiratory-burst","display_name":"respiratory burst","score":0.9950000047683716},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9679999947547913},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.8870000243186951},{"id":"https://openalex.org/keywords/zymosan","display_name":"zymosan","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cell-membrane-damage","display_name":"cell membrane damage","score":0.6150000095367432},{"id":"https://openalex.org/keywords/cytosolic-release","display_name":"cytosolic release","score":0.5989999771118164},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C2778870864","wikidata":"https://www.wikidata.org/wiki/Q3083725","display_name":"Zymosan","level":3,"score":0.8447632789611816},{"id":"https://openalex.org/C99971728","wikidata":"https://www.wikidata.org/wiki/Q838181","display_name":"Respiratory burst","level":2,"score":0.6890142560005188},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6882253885269165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6199482083320618},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.5716392993927002},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4897198975086212},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4674924910068512},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.4660284221172333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44875770807266235},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39553746581077576},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3534192740917206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27522218227386475},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2560286223888397},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2241232693195343},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07341247797012329},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9276001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9276001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer","raw_type":"Journal Article"},{"id":"mag:2464974158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9276001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083143470","https://openalex.org/W2029628372","https://openalex.org/W2080049917","https://openalex.org/W4249812917","https://openalex.org/W2041999489","https://openalex.org/W2034396729","https://openalex.org/W2150764365","https://openalex.org/W1987516870","https://openalex.org/W2031018453","https://openalex.org/W1976786481"],"abstract_inverted_index":{"Alveolar":[0],"macrophages":[1],"lie":[2],"on":[3,96],"the":[4,8,12,54,79,90,97,106,145,165,176,180,197,201,213,216,226,231,235,244,257,267,270,284],"air":[5],"side":[6],"of":[7,11,56,82,92,121,150,162,167,175,194,200,208,230,237,269],"alveolar-capillary":[9],"barrier":[10],"lung.":[13],"They":[14],"originate":[15],"from":[16,105,225,283],"circulating":[17],"monocytes":[18,30,103,233],"and":[19,31,42,124,173,186,219,276,286],"are":[20,63],"an":[21,37],"important":[22],"first-line":[23],"host":[24],"defense":[25],"against":[26],"inhaled":[27],"microorganisms.":[28],"In":[29,100],"macrophages,":[32,84],"phagocytosis":[33],"is":[34,53,71,87,289],"associated":[35],"with":[36,118,130,137,184,215,240],"increase":[38],"in":[39,196,302],"O2":[40],"consumption":[41],"superoxide":[43,146,287],"anion":[44],"(O2-)":[45],"generation,":[46],"that":[47,62,74,204,256,265],"is,":[48],"\"the":[49],"respiratory":[50,98],"burst\".":[51],"O2-":[52,141,168,280],"precursor":[55],"highly":[57],"reactive,":[58],"oxygen-derived":[59],"free":[60],"radicals":[61],"used":[64],"to":[65,171,294],"kill":[66],"potential":[67],"pathogens.":[68],"Although":[69],"it":[70],"well":[72],"known":[73,88],"airborne":[75,93,258],"particulate":[76,94,122,160,259],"matter":[77,260],"inhibits":[78],"phagocytic":[80],"activity":[81],"alveolar":[83],"very":[85],"little":[86],"about":[89],"effect":[91,264],"extracts":[95],"burst.":[99],"this":[101,298],"study,":[102],"isolated":[104],"peripheral":[107],"blood":[108],"were":[109,182,210,223],"incubated":[110],"for":[111,127,279],"2":[112],"hr":[113],"at":[114,158],"37":[115],"degrees":[116],"C":[117],"increasing":[119],"concentrations":[120],"extract":[123],"then":[125],"stimulated":[126,183],"30":[128],"min":[129],"phorbol":[131],"12-myristate":[132],"13":[133],"acetate":[134],"(PMA)":[135],"or":[136],"Zymosan.":[138],"The":[139,153],"released":[140,224],"was":[142,169,191,254],"measured":[143],"by":[144,212],"dismutase":[147],"inhibitable":[148],"reduction":[149],"cytochrome":[151],"C.":[152],"results":[154],"cleary":[155],"showed":[156],"that,":[157],"a":[159,192,205,241,250,262],"concentration":[161],"0.17":[163],"mg/mL,":[164],"production":[166,281],"reduced":[170],"22%":[172],"40%":[174],"control":[177],"values":[178],"when":[179],"cells":[181,209,239,285],"PMA":[185],"Zymosan,":[187],"respectively.":[188],"Concomitantly,":[189],"there":[190],"release":[193],"LDH":[195],"supernatant":[198],"(50%":[199],"total),":[202],"indicating":[203],"large":[206],"proportion":[207],"damaged":[211],"treatment":[214],"environmental":[217],"pollutants,":[218],"some":[220],"cytosolic":[221],"components":[222],"cells.":[227],"Giemsa":[228],"staining":[229],"treated":[232],"revealed":[234],"presence":[236],"many":[238],"dispersed":[242],"cytosol;":[243],"nucleus,":[245],"although":[246],"not":[247],"destroyed,":[248],"had":[249],"different":[251],"shape.":[252],"It":[253,292],"suggested":[255],"has":[261],"toxic":[263],"induces":[266],"disintegration":[268],"plasma":[271],"membrane.":[272],"Cytosolic":[273],"factors":[274],"(proteins":[275],"coenzymes)":[277],"necessary":[278],"leak":[282],"generation":[288],"therefore":[290],"reduced.":[291],"remains":[293],"be":[295],"determined":[296],"whether":[297],"phenomenon":[299],"also":[300],"occurs":[301],"vivo.":[303]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
