{"id":"https://openalex.org/W2464949422","doi":"https://doi.org/10.1039/c6nr02974d","title":"Nanoconjugation prolongs endosomal signaling of the epidermal growth factor receptor and enhances apoptosis","display_name":"Nanoconjugation prolongs endosomal signaling of the epidermal growth factor receptor and enhances apoptosis","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2464949422","doi":"https://doi.org/10.1039/c6nr02974d","mag":"2464949422","pmid":"https://pubmed.ncbi.nlm.nih.gov/27378391","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5081566"},"language":"en","primary_location":{"id":"doi:10.1039/c6nr02974d","doi":"https://doi.org/10.1039/c6nr02974d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c6nr02974d","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5081566","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110147065","display_name":"Linxi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Wu","raw_affiliation_strings":["Boston University","Boston, USA","Department of Chemistry and The Photonics Center","Department of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and The Photonics Center","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004517900","display_name":"Fangda Xu","orcid":"https://orcid.org/0009-0007-9966-864X","observed_orcids":["https://orcid.org/0009-0007-9966-864X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Xu","raw_affiliation_strings":["Boston University","Boston, USA","Department of Chemistry and The Photonics Center","Department of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and The Photonics Center","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067330655","display_name":"Bj\u00f6rn M. Reinhard","orcid":"https://orcid.org/0000-0003-2550-5331","observed_orcids":["https://orcid.org/0000-0003-2550-5331"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B. M. Reinhard","raw_affiliation_strings":["Boston University","Boston, USA","Department of Chemistry and The Photonics Center","Department of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and The Photonics Center","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067330655"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":null,"apc_paid":null,"fwci":1.0457,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.69368973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"28","first_page":"13755","last_page":"13768"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.133200004696846,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9459999799728394},{"id":"https://openalex.org/keywords/egf-signaling","display_name":"EGF signaling","score":0.5839999914169312},{"id":"https://openalex.org/keywords/early-endosomes","display_name":"early endosomes","score":0.8410000205039978},{"id":"https://openalex.org/keywords/receptor-phosphorylation","display_name":"receptor phosphorylation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.9444971084594727},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7868055105209351},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7191169261932373},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6210799813270569},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5804135799407959},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.46428409218788147},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4396364688873291},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4385787844657898},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41852816939353943},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3754790127277374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23760545253753662},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10308602452278137},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.037333935499191284}],"mesh":[{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1039/c6nr02974d","doi":"https://doi.org/10.1039/c6nr02974d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c6nr02974d","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:27378391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27378391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5081566","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5081566","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanoscale","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5081566","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5081566","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanoscale","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2405771447","display_name":"Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor Signal Transduction Pathway Using Plasmon Coupling","funder_award_id":"R01CA138509","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W654122616","https://openalex.org/W1268908084","https://openalex.org/W1587227490","https://openalex.org/W1815158833","https://openalex.org/W1942214720","https://openalex.org/W1942708165","https://openalex.org/W1964321121","https://openalex.org/W1964746125","https://openalex.org/W1964966535","https://openalex.org/W1966311581","https://openalex.org/W1969117282","https://openalex.org/W1970238879","https://openalex.org/W1973681903","https://openalex.org/W1976041621","https://openalex.org/W1983723803","https://openalex.org/W1986137370","https://openalex.org/W1993331221","https://openalex.org/W1994266956","https://openalex.org/W1996139192","https://openalex.org/W1999364829","https://openalex.org/W2000749669","https://openalex.org/W2002429753","https://openalex.org/W2004987572","https://openalex.org/W2005574904","https://openalex.org/W2007719101","https://openalex.org/W2009993736","https://openalex.org/W2014261553","https://openalex.org/W2015704490","https://openalex.org/W2017886031","https://openalex.org/W2019772485","https://openalex.org/W2020791325","https://openalex.org/W2023861623","https://openalex.org/W2024502310","https://openalex.org/W2025429964","https://openalex.org/W2026494961","https://openalex.org/W2028415754","https://openalex.org/W2028531434","https://openalex.org/W2031933070","https://openalex.org/W2035697316","https://openalex.org/W2038122461","https://openalex.org/W2038326186","https://openalex.org/W2045377189","https://openalex.org/W2045583680","https://openalex.org/W2049253479","https://openalex.org/W2052591337","https://openalex.org/W2054735667","https://openalex.org/W2056442594","https://openalex.org/W2056787790","https://openalex.org/W2060416249","https://openalex.org/W2061497413","https://openalex.org/W2075570230","https://openalex.org/W2077228161","https://openalex.org/W2078636414","https://openalex.org/W2079116168","https://openalex.org/W2082315732","https://openalex.org/W2082543204","https://openalex.org/W2083219195","https://openalex.org/W2085263133","https://openalex.org/W2085365699","https://openalex.org/W2093279818","https://openalex.org/W2095248480","https://openalex.org/W2097097666","https://openalex.org/W2097840191","https://openalex.org/W2099133435","https://openalex.org/W2099335992","https://openalex.org/W2102449174","https://openalex.org/W2104257202","https://openalex.org/W2106181213","https://openalex.org/W2111309386","https://openalex.org/W2113972541","https://openalex.org/W2115271408","https://openalex.org/W2116422958","https://openalex.org/W2117692326","https://openalex.org/W2119398013","https://openalex.org/W2125233904","https://openalex.org/W2125614971","https://openalex.org/W2129998516","https://openalex.org/W2138321569","https://openalex.org/W2143891754","https://openalex.org/W2166155213","https://openalex.org/W2170019668","https://openalex.org/W2224153875","https://openalex.org/W2312836697","https://openalex.org/W2315643348","https://openalex.org/W2318663109","https://openalex.org/W2325707043","https://openalex.org/W2326407270","https://openalex.org/W2327573547","https://openalex.org/W2336933474","https://openalex.org/W2406928924","https://openalex.org/W2620241325","https://openalex.org/W4211075026","https://openalex.org/W4256245095","https://openalex.org/W4256503849"],"related_works":["https://openalex.org/W2625520370","https://openalex.org/W3016357073","https://openalex.org/W2075570230","https://openalex.org/W3113910343","https://openalex.org/W2916205210","https://openalex.org/W4292616314","https://openalex.org/W2076395634","https://openalex.org/W4384500367","https://openalex.org/W2909150868","https://openalex.org/W2104257202"],"abstract_inverted_index":{"It":[0],"is":[1,108],"becoming":[2],"increasingly":[3],"clear":[4],"that":[5,84,98,118,141],"intracellular":[6,39,62],"signaling":[7,21,40,140],"can":[8],"be":[9],"subject":[10],"to":[11,23],"strict":[12],"spatial":[13],"control.":[14],"As":[15],"the":[16,47,61,87,94,99,105,124,145,149],"covalent":[17],"attachment":[18],"of":[19,49,64,90,101,126,148],"a":[20,24,42,135],"ligand":[22],"nanoparticle":[25],"(NP)":[26],"impacts":[27],"ligand-receptor":[28,152],"binding,":[29],"uptake,":[30],"and":[31,68,78,97],"trafficking,":[32],"nanoconjugation":[33,50,85,133],"provides":[34],"new":[35],"opportunities":[36],"for":[37,138],"manipulating":[38],"in":[41,93,104,123],"controlled":[43],"fashion.":[44],"To":[45],"establish":[46],"effect":[48],"on":[51],"epidermal":[52],"growth":[53],"factor":[54],"(EGF)":[55],"mediated":[56,113],"signaling,":[57],"we":[58],"investigate":[59],"here":[60],"fate":[63],"nanoconjugated":[65],"EGF":[66,112],"(NP-EGF)":[67],"its":[69],"bound":[70],"receptor":[71],"(EGFR)":[72],"by":[73,110,143],"quantitative":[74],"correlated":[75],"darkfield/fluorescence":[76],"microscopy":[77],"density-based":[79],"endosomal":[80],"fractionation.":[81],"We":[82],"demonstrate":[83],"prolongs":[86],"dwell":[88],"time":[89],"phosphorylated":[91],"receptors":[92],"early":[95,106],"endosomes":[96,107],"retention":[100],"activated":[102,150],"EGFR":[103],"accompanied":[109],"an":[111],"apoptosis":[114,122],"at":[115],"effective":[116],"concentrations":[117],"do":[119],"not":[120],"induce":[121],"case":[125],"free":[127],"EGF.":[128],"Overall,":[129],"these":[130],"findings":[131],"indicate":[132],"as":[134],"rational":[136],"strategy":[137],"modifying":[139],"acts":[142],"modulating":[144],"temporo-spatial":[146],"distribution":[147],"EGF-EGFR":[151],"complex.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
