{"id":"https://openalex.org/W2464748959","doi":"https://doi.org/10.1111/hae.13028","title":"Extended half\u2010life clotting factor concentrates: results from published clinical trials","display_name":"Extended half\u2010life clotting factor concentrates: results from published clinical trials","publication_year":2016,"publication_date":"2016-07-01","ids":{"openalex":"https://openalex.org/W2464748959","doi":"https://doi.org/10.1111/hae.13028","mag":"2464748959","pmid":"https://pubmed.ncbi.nlm.nih.gov/27405672"},"language":"en","primary_location":{"id":"doi:10.1111/hae.13028","doi":"https://doi.org/10.1111/hae.13028","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.13028","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.13028","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.13028","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004338432","display_name":"Guy A. Young","orcid":"https://orcid.org/0000-0001-6013-1254","observed_orcids":["https://orcid.org/0000-0001-6013-1254"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G. Young","raw_affiliation_strings":["Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087552786","display_name":"Johnny Ndoni Mahlangu","orcid":"https://orcid.org/0000-0001-5781-7669","observed_orcids":["https://orcid.org/0000-0001-5781-7669"]},"institutions":[{"id":"https://openalex.org/I107920810","display_name":"National Health Laboratory Service","ror":"https://ror.org/00znvbk37","country_code":"ZA","type":"government","lineage":["https://openalex.org/I107920810"]},{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]},{"id":"https://openalex.org/I2799742747","display_name":"Johannesburg Hospital","ror":"https://ror.org/047x96110","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I2799742747"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"J. N. Mahlangu","raw_affiliation_strings":["Haemophilia Comprehensive Care Centre, Charlotte Maxeke Johannesburg Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemophilia Comprehensive Care Centre, Charlotte Maxeke Johannesburg Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa","institution_ids":["https://openalex.org/I107920810","https://openalex.org/I192619145","https://openalex.org/I2799742747"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004338432"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":5.1639,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.95667723,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"S5","first_page":"25","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.984000027179718},{"id":"https://openalex.org/keywords/hemophilia-b","display_name":"hemophilia B","score":1.0},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.703000009059906},{"id":"https://openalex.org/keywords/factor-ix","display_name":"factor IX","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/inhibitor-development","display_name":"inhibitor development","score":0.6819999814033508},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.5860000252723694},{"id":"https://openalex.org/keywords/central-venous-catheters","display_name":"central venous catheters","score":0.7400000095367432},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.918601393699646},{"id":"https://openalex.org/C2778385053","wikidata":"https://www.wikidata.org/wiki/Q134003","display_name":"Haemophilia","level":2,"score":0.9063907861709595},{"id":"https://openalex.org/C2992139802","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Clotting factor","level":2,"score":0.7831524610519409},{"id":"https://openalex.org/C2781221834","wikidata":"https://www.wikidata.org/wiki/Q425360","display_name":"Factor IX","level":2,"score":0.600904643535614},{"id":"https://openalex.org/C2777232031","wikidata":"https://www.wikidata.org/wiki/Q2092064","display_name":"Haemophilia A","level":3,"score":0.5685732364654541},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5616055727005005},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5452197194099426},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4994163513183594},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4379720985889435},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3517208695411682},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2656383514404297},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002836","descriptor_name":"Hemophilia B","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005164","descriptor_name":"Factor IX","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005164","descriptor_name":"Factor IX","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005164","descriptor_name":"Factor IX","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/hae.13028","doi":"https://doi.org/10.1111/hae.13028","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.13028","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.13028","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},{"id":"pmid:27405672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27405672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia : the official journal of the World Federation of Hemophilia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/hae.13028","doi":"https://doi.org/10.1111/hae.13028","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.13028","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.13028","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306923","display_name":"CSL Behring Foundation for Research and Advancement of Patient Health","ror":"https://ror.org/01jxhxv92"},{"id":"https://openalex.org/F4320307771","display_name":"Bayer","ror":"https://ror.org/04hmn8g73"},{"id":"https://openalex.org/F4320307779","display_name":"Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320311257","display_name":"Baxalta","ror":"https://ror.org/040fqas51"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2464748959.pdf","grobid_xml":"https://content.openalex.org/works/W2464748959.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W592698445","https://openalex.org/W1552409234","https://openalex.org/W1623696825","https://openalex.org/W1964898159","https://openalex.org/W1969271703","https://openalex.org/W1969941406","https://openalex.org/W1971751613","https://openalex.org/W1974965024","https://openalex.org/W1976624075","https://openalex.org/W1997085090","https://openalex.org/W2006458114","https://openalex.org/W2016608925","https://openalex.org/W2025533860","https://openalex.org/W2026336161","https://openalex.org/W2027319450","https://openalex.org/W2059843712","https://openalex.org/W2072339301","https://openalex.org/W2074841269","https://openalex.org/W2085306050","https://openalex.org/W2086294372","https://openalex.org/W2103381450","https://openalex.org/W2160761181","https://openalex.org/W2198649373","https://openalex.org/W2291672567","https://openalex.org/W2315516779","https://openalex.org/W2527024438","https://openalex.org/W2551654419","https://openalex.org/W2560258170","https://openalex.org/W2614074982","https://openalex.org/W2979805398","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2081187509","https://openalex.org/W2891041376","https://openalex.org/W7134232998","https://openalex.org/W1565617506","https://openalex.org/W1586003096","https://openalex.org/W2425394528","https://openalex.org/W2054458899","https://openalex.org/W2604999345","https://openalex.org/W2946273518","https://openalex.org/W2956862224"],"abstract_inverted_index":{"Extended":[0],"half-life":[1,51,97,118,187],"clotting":[2,188],"factor":[3,98,119,189],"concentrates":[4],"have":[5,28,122,164],"been":[6,166],"recently":[7],"introduced":[8],"into":[9,208],"the":[10,23,46,83,116,124,170,194,197],"armamentarium":[11],"of":[12,48,58,91,126,180,185],"treatments":[13],"for":[14,53,76,128,139,147,172,196],"patients":[15,42,67,104,129,141,149,163],"with":[16,35,45,88],"haemophilia":[17,198,209],"A":[18],"and":[19,43,142,169,193],"B.":[20],"In":[21],"general,":[22],"data":[24,159],"from":[25,160],"published":[26,167],"studies":[27],"demonstrated":[29],"these":[30,206],"products":[31,100,121,190,207],"to":[32,65,72,82,85,105,132,143,156,203],"be":[33,201],"safe":[34],"no":[36],"inhibitors":[37,173],"reported":[38],"in":[39,174],"previously":[40,69,161],"treated":[41],"efficacious":[44],"advantage":[47],"a":[49],"longer":[50],"allowing":[52,103],"less":[54],"frequent":[55],"intravenous":[56],"infusions":[57],"factor.":[59],"This":[60],"enhanced":[61],"convenience":[62],"has":[63,80,191],"led":[64,81],"some":[66,140],"not":[68,165],"on":[70,130],"prophylaxis":[71,74,87,131],"begin":[73],"while":[75,110,115],"others,":[77],"especially":[78],"children,":[79],"ability":[84],"provide":[86],"reduced":[89,123],"use":[90],"central":[92],"venous":[93],"catheters.":[94],"The":[95,183],"extended":[96,117,186],"IX":[99],"are":[101],"now":[102],"dose":[106],"every":[107],"1-2":[108],"weeks":[109],"maintaining":[111],"higher":[112],"trough":[113],"levels":[114],"VIII":[120],"frequency":[125],"administration":[127],"as":[133,135,179],"infrequent":[134],"once":[136],"per":[137,145],"week":[138,146],"twice":[144],"all":[148],"including":[150],"younger":[151],"children.":[152],"It":[153],"is":[154,178],"important":[155],"note":[157],"that":[158],"untreated":[162],"yet":[168,181],"incidence":[171],"this":[175],"patient":[176],"population":[177],"unknown.":[182],"era":[184],"begun":[192],"challenge":[195],"community":[199],"will":[200],"how":[202],"best":[204],"integrate":[205],"clinical":[210],"practice.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
