{"id":"https://openalex.org/W2464535652","doi":null,"title":"Effects of tumor necrosis factor-alpha on calcium movement in rat ventricular myocytes.","display_name":"Effects of tumor necrosis factor-alpha on calcium movement in rat ventricular myocytes.","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W2464535652","mag":"2464535652","pmid":"https://pubmed.ncbi.nlm.nih.gov/14653948"},"language":"en","primary_location":{"id":"pmid:14653948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14653948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W2464535652"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100339643","display_name":"Xiaoqiang Li","orcid":"https://orcid.org/0000-0003-2463-8298","observed_orcids":["https://orcid.org/0000-0003-2463-8298"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Qiang Li","raw_affiliation_strings":["Department of Pharmacology, The Fourth Military Medical University, Xi-an 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The Fourth Military Medical University, Xi-an 710032, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008968270","display_name":"Ming Zhao","orcid":"https://orcid.org/0000-0002-7539-3887","observed_orcids":["https://orcid.org/0000-0002-7539-3887"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming-Gao Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055309139","display_name":"Qibing Mei","orcid":"https://orcid.org/0000-0001-7460-5115","observed_orcids":["https://orcid.org/0000-0001-7460-5115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi-Bing Mei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yan-Feng Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan-Feng Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075819658","display_name":"Haifang Wang","orcid":"https://orcid.org/0000-0002-7660-2089","observed_orcids":["https://orcid.org/0000-0002-7660-2089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai-Fang Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101564449","display_name":"Dan Chen","orcid":"https://orcid.org/0000-0002-7815-2587","observed_orcids":["https://orcid.org/0000-0002-7815-2587"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101851336","display_name":"Yi Cui","orcid":"https://orcid.org/0000-0002-7649-8664","observed_orcids":["https://orcid.org/0000-0002-7649-8664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Cui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6502,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.73554468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"24","issue":"12","first_page":"1224","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.049400001764297485,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/l-type-calcium-current","display_name":"L-type calcium current","score":0.8690000176429749},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8289999961853027},{"id":"https://openalex.org/keywords/calcium-release-from-intracellular-stores","display_name":"calcium release from intracellular stores","score":0.7440000176429749},{"id":"https://openalex.org/keywords/nicardipine","display_name":"nicardipine","score":0.871999979019165},{"id":"https://openalex.org/keywords/steady-state-inactivation","display_name":"steady-state inactivation","score":0.781000018119812},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.4519999921321869},{"id":"https://openalex.org/keywords/cardiac-ion-channels","display_name":"cardiac ion channels","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6613707542419434},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5533728003501892},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.5366603136062622},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5251436233520508},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.5216667652130127},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5210756063461304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48594963550567627},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4773566722869873},{"id":"https://openalex.org/C2778043224","wikidata":"https://www.wikidata.org/wiki/Q729213","display_name":"Nicardipine","level":3,"score":0.4486980140209198},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4448360800743103},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33249688148498535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2528747320175171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22293993830680847},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.1986018419265747},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1391124427318573}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14653948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14653948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:2464535652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14653948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038189746","https://openalex.org/W2047052635","https://openalex.org/W835382339","https://openalex.org/W2924049413","https://openalex.org/W2356111855","https://openalex.org/W2922956816","https://openalex.org/W2112419965","https://openalex.org/W2369494297","https://openalex.org/W645437729","https://openalex.org/W2007887289"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"study":[2],"the":[3,40,44,69,87,169,176,212,219],"effects":[4,194],"of":[5,43,71,105,173,221],"tumor":[6],"necrosis":[7],"factor-alpha":[8],"(TNF-alpha)":[9],"on":[10,195],"calcium":[11,25,34,72],"movement":[12],"in":[13,63,117,206],"rat":[14,207],"ventricular":[15,208],"myocytes.":[16],"METHODS:":[17],"Intracellular":[18],"free":[19,60,107,214],"Ca2+":[20,61,215,222],"concentration":[21,62],"was":[22,37,55,111],"measured":[23],"with":[24,39,75],"fluorescent":[26],"probe":[27],"Fluo-3/AM":[28],"and":[29,51,124,154,198],"laser":[30,76],"confocal":[31,77],"microscope.":[32,78],"L-type":[33],"current":[35],"(ICa,L)":[36],"recorded":[38],"whole-cell":[41,118],"configuration":[42],"patch-clamp":[45,119],"techniques.":[46],"RESULTS:":[47],"At":[48,121],"2,":[49,122],"20":[50],"200":[52,125],"microg/L,":[53,126],"TNF-alpha":[54,99,114,127,203],"found":[56,112],"to":[57,92,101,175,184,218],"increase":[58],"intracellular":[59,106,224],"a":[64],"dose-dependent":[65],"manner":[66],"illustrated":[67],"by":[68,131],"increment":[70],"fluorescence":[73],"density":[74],"Nicardipine":[79],"0.5":[80],"micromol/L":[81],"slightly":[82],"attenuated":[83],"TNF-alpha-induced":[84],"response.":[85],"When":[86],"cardiac":[88],"myocytes":[89],"were":[90],"exposed":[91],"caffeine":[93],"(100":[94],"mmol/L)":[95],"for":[96],"30":[97],"min,":[98],"failed":[100],"induce":[102],"any":[103],"change":[104],"calcium.":[108],"However,":[109],"it":[110,191],"that":[113],"inhibited":[115,204],"I(Ca,L)":[116,130,174,205],"experiments.":[120],"20,":[123],"decreased":[128],"peak":[129],"3.9":[132],"%":[133,144,156],"(-5.1":[134,145,157],"pA/pF+/-0.3":[135,146,150,158],"pA/pF":[136,147,159],"vs":[137,148,160],"-4.9":[138],"pA/pF+/-0.2":[139],"pA/pF,":[140,151,163],"n=9,":[141,152,164],"P>0.05),":[142],"15.7":[143],"-4.3":[149],"P<0.05)":[153],"19.6":[155],"-4.1":[161],"pA/pF+/-0.4":[162],"P<0.01),":[165],"respectively.":[166],"It":[167],"shifted":[168,179],"steady-state":[170,196],"inactivation":[171],"curve":[172],"left":[177],"(V1/2":[178],"from":[180,200,223],"-28.7":[181],"mV+/-0.3":[182],"mV":[183],"-37.8":[185],"mV+/-1.4":[186],"mV,":[187],"n=7,":[188],"P<0.05),":[189],"while":[190,210],"took":[192],"no":[193],"activation":[197],"recovery":[199],"inactivation.":[201],"CONCLUSION:":[202],"myocytes,":[209],"increasing":[211],"intercellular":[213],"level":[216],"due":[217],"release":[220],"stores.":[225]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
