{"id":"https://openalex.org/W2464448564","doi":"https://doi.org/10.1128/jb.00294-16","title":"The Last r Locus Unveiled: T4 RIII Is a Cytoplasmic Antiholin","display_name":"The Last r Locus Unveiled: T4 RIII Is a Cytoplasmic Antiholin","publication_year":2016,"publication_date":"2016-07-06","ids":{"openalex":"https://openalex.org/W2464448564","doi":"https://doi.org/10.1128/jb.00294-16","mag":"2464448564","pmid":"https://pubmed.ncbi.nlm.nih.gov/27381920"},"language":"en","primary_location":{"id":"doi:10.1128/jb.00294-16","doi":"https://doi.org/10.1128/jb.00294-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.00294-16","pdf_url":"https://jb.asm.org/content/jb/198/18/2448.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jb.asm.org/content/jb/198/18/2448.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100419220","display_name":"Yi Chen","orcid":"https://orcid.org/0000-0001-7146-3975","observed_orcids":["https://orcid.org/0000-0001-7146-3975"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Chen","raw_affiliation_strings":["Center for Phage Technology, Texas A&amp;M University, College Station, Texas, USA","Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Phage Technology, Texas A&amp;M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028655504","display_name":"Ry Young","orcid":"https://orcid.org/0000-0001-8001-2914","observed_orcids":["https://orcid.org/0000-0001-8001-2914"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ry Young","raw_affiliation_strings":["Center for Phage Technology, Texas A&amp;M University, College Station, Texas, USA","Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Phage Technology, Texas A&amp;M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":1.9859,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.85303729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"198","issue":"18","first_page":"2448","last_page":"2457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacteriophage-t4","display_name":"bacteriophage T4","score":0.890999972820282},{"id":"https://openalex.org/keywords/phage-lysis","display_name":"phage lysis","score":0.5740000009536743},{"id":"https://openalex.org/keywords/membrane-permeabilization","display_name":"membrane permeabilization","score":0.8349999785423279},{"id":"https://openalex.org/keywords/superinfection","display_name":"superinfection","score":0.7260000109672546},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7839999794960022},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9250696897506714},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6037351489067078},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5382245779037476},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.471591591835022},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14955514669418335}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017122","descriptor_name":"Bacteriophage T4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017122","descriptor_name":"Bacteriophage T4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017122","descriptor_name":"Bacteriophage T4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057074","descriptor_name":"Virus Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057074","descriptor_name":"Virus Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057074","descriptor_name":"Virus Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jb.00294-16","doi":"https://doi.org/10.1128/jb.00294-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.00294-16","pdf_url":"https://jb.asm.org/content/jb/198/18/2448.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmid:27381920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27381920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4999926","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4999926","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/180841","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/180841","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"doi:10.1128/jb.00294-16","doi":"https://doi.org/10.1128/jb.00294-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.00294-16","pdf_url":"https://jb.asm.org/content/jb/198/18/2448.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","score":0.550000011920929,"display_name":"Life on land"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1043083363","display_name":"CONTROL OF VIRUS INDUCED LYSIS","funder_award_id":"R37GM027099","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2040398346","display_name":null,"funder_award_id":"GM27099","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G8334644758","display_name":null,"funder_award_id":"R01 GM027099","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2464448564.pdf","grobid_xml":"https://content.openalex.org/works/W2464448564.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W220070148","https://openalex.org/W1479966051","https://openalex.org/W1580017026","https://openalex.org/W1604284105","https://openalex.org/W1760978447","https://openalex.org/W1763795632","https://openalex.org/W1852844868","https://openalex.org/W1887260387","https://openalex.org/W1892161004","https://openalex.org/W1938897093","https://openalex.org/W1964752230","https://openalex.org/W1967534828","https://openalex.org/W1975414190","https://openalex.org/W1995280127","https://openalex.org/W2008365039","https://openalex.org/W2013736176","https://openalex.org/W2021584093","https://openalex.org/W2026535661","https://openalex.org/W2034912210","https://openalex.org/W2041942886","https://openalex.org/W2047670590","https://openalex.org/W2059500096","https://openalex.org/W2060011824","https://openalex.org/W2068903512","https://openalex.org/W2070906511","https://openalex.org/W2074046561","https://openalex.org/W2075601567","https://openalex.org/W2076716973","https://openalex.org/W2083818002","https://openalex.org/W2093529725","https://openalex.org/W2094049400","https://openalex.org/W2096205995","https://openalex.org/W2099898868","https://openalex.org/W2103080995","https://openalex.org/W2112773023","https://openalex.org/W2112812495","https://openalex.org/W2113369659","https://openalex.org/W2146668848","https://openalex.org/W2148641266","https://openalex.org/W2154927969","https://openalex.org/W2287705443","https://openalex.org/W2322217549","https://openalex.org/W2505019356","https://openalex.org/W2613645997"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2133790197","https://openalex.org/W2056064843","https://openalex.org/W2147212144","https://openalex.org/W2182810250","https://openalex.org/W2115675860","https://openalex.org/W1886625688","https://openalex.org/W2052173596","https://openalex.org/W2058209790","https://openalex.org/W2028554823"],"abstract_inverted_index":{"UNLABELLED:":[0],"The":[1,138],"latent":[2],"period":[3],"of":[4,50,77,87,99,140,152,177,219,222,228,237,249,261,280,315],"phage":[5,262],"T4,":[6],"normally":[7],"\u223c25":[8],"min,":[9],"can":[10],"be":[11,56],"extended":[12],"indefinitely":[13],"if":[14],"the":[15,33,47,59,73,78,88,97,173,204,217,229,234,240,246,252,271,277,281,293,304],"infected":[16],"cell":[17,320],"is":[18,36,112,180,191,257],"superinfected":[19],"after":[20],"5":[21],"min.":[22],"This":[23],"phenomenon,":[24],"designated":[25],"lysis":[26,148],"inhibition":[27,256],"(LIN),":[28],"was":[29,132,136],"first":[30],"described":[31],"in":[32,41,117,157,225,239,251,264],"1940s":[34],"and":[35,82,123,154,165,242,284],"genetically":[37],"defined":[38],"by":[39,64,200,270,311],"mutations":[40],"diverse":[42],"T4":[43,79,193,213,263,294],"r":[44,92],"genes.":[45],"RI,":[46,273,307],"main":[48,305],"effector":[49],"LIN,":[51],"has":[52,95],"been":[53,96],"shown":[54],"to":[55,58,72,266,276],"secreted":[57],"periplasm,":[60],"where,":[61],"upon":[62],"activation":[63],"superinfection":[65],"with":[66,172,203,233,245,303],"a":[67,141,158,181,192,220,258,298,313],"T-even":[68],"virion,":[69],"it":[70],"binds":[71,275],"C-terminal":[74],"periplasmic":[75,278],"domain":[76,183,279],"holin":[80,185,283,309],"T":[81,238,250,282,310],"blocks":[83,196,285],"its":[84,286],"lethal":[85],"permeabilization":[86],"cytoplasmic":[89,174,299],"membrane.":[90],"Another":[91],"locus,":[93],"rIII,":[94],"subject":[98],"conflicting":[100],"reports.":[101],"In":[102,128],"this":[103],"study,":[104],"we":[105,207,290],"show":[106],"that":[107,169,189,195,215,292],"RIII,":[108],"an":[109,209],"82-amino-acid":[110],"protein,":[111],"also":[113],"required":[114],"for":[115,184,212],"LIN":[116,131,160,214],"both":[118],"Escherichia":[119],"coli":[120,125],"B":[121],"strains":[122],"E.":[124],"K-12":[126],"strains.":[127],"T4\u0394rIII":[129],"infections,":[130],"briefly":[133],"established":[134],"but":[135],"unstable.":[137],"overexpression":[139],"cloned":[142],"rIII":[143,153,296],"gene":[144,295],"alone":[145],"impeded":[146],"T-mediated":[147],"temporarily.":[149],"However,":[150],"coexpression":[151],"rI":[155],"resulted":[156],"stable":[159],"state.":[161],"Bacterial":[162],"two-hybrid":[163],"assays":[164,167],"pulldown":[166],"showed":[168],"RIII":[170,190,243],"interacts":[171],"N":[175,247],"terminus":[176,236,248],"T,":[178],"which":[179,274],"critical":[182],"function.":[186,288],"We":[187],"conclude":[188],"antiholin":[194,272,300],"membrane":[197],"hole":[198],"formation":[199],"interacting":[201,232,244],"directly":[202],"holin.":[205],"Accordingly,":[206],"propose":[208],"augmented":[210],"model":[211],"involves":[216],"stabilization":[218],"complex":[221,314],"three":[223,316],"proteins":[224,317],"two":[226,319],"compartments":[227],"cell:":[230],"RI":[231],"C":[235],"periplasm":[241],"cytoplasm.":[253],"IMPORTANCE:":[254],"Lysis":[255],"unique":[259],"feature":[260],"response":[265],"environmental":[267],"conditions,":[268],"effected":[269],"hole-forming":[287],"Here":[289],"report":[291],"encodes":[297],"that,":[301],"together":[302],"antiholin,":[306],"inhibits":[308],"forming":[312],"spanning":[318],"compartments.":[321]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-07-22T00:00:00"}
