{"id":"https://openalex.org/W2464038992","doi":null,"title":"[Reevaluation of indications for adjuvant hormone therapy in primary breast cancer with high metastatic risk].","display_name":"[Reevaluation of indications for adjuvant hormone therapy in primary breast cancer with high metastatic risk].","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2464038992","mag":"2464038992","pmid":"https://pubmed.ncbi.nlm.nih.gov/1932838"},"language":"fr","primary_location":{"id":"pmid:1932838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1932838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin du cancer","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109128780","display_name":"Pierre\u2010Marie Martin","orcid":"https://orcid.org/0009-0007-8111-2897","observed_orcids":["https://orcid.org/0009-0007-8111-2897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Martin","raw_affiliation_strings":["Service d'oncologie m\u00e9dicale-biopathologie, facult\u00e9 de m\u00e9decine Nord, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'oncologie m\u00e9dicale-biopathologie, facult\u00e9 de m\u00e9decine Nord, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113058696","display_name":"S Romain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Romain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110015491","display_name":"F. Spyratos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Spyratos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109908641","display_name":"J M Spitalier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Spitalier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018883404","display_name":"Yves Ayme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ayme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027286177","display_name":"Henri Brandone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Brandone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044043166","display_name":"C Bressac","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Bressac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020624203","display_name":"Daniel Hans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Hans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088324209","display_name":"Jocelyne D. Jacquemier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Jacquemier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110043435","display_name":"K. Hac\u00e8ne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Hacene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.30649559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"78","issue":"8","first_page":"709","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adjuvant-endocrine-therapy","display_name":"adjuvant endocrine therapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/primary-breast-cancer","display_name":"primary breast cancer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.7990000247955322},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/menopausal-status","display_name":"menopausal status","score":0.984000027179718},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9810000061988831},{"id":"https://openalex.org/keywords/oophorectomy","display_name":"oophorectomy","score":0.996999979019165},{"id":"https://openalex.org/keywords/therapeutic-indications","display_name":"treatment indications","score":0.4009999930858612},{"id":"https://openalex.org/keywords/treatment-response-heterogeneity","display_name":"treatment response heterogeneity","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8871457576751709},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.766607403755188},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6835298538208008},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6512497663497925},{"id":"https://openalex.org/C2778311097","wikidata":"https://www.wikidata.org/wiki/Q5903784","display_name":"Hormonal therapy","level":4,"score":0.6348760724067688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5909175276756287},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.5813499689102173},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5658107399940491},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5474439859390259},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.545281708240509},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5104228854179382},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4525829553604126},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4431007504463196},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4409591555595398},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.4393477439880371},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1932838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1932838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin du cancer","raw_type":"Clinical Trial"},{"id":"mag:2464038992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1932838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2461933174","https://openalex.org/W2018760628","https://openalex.org/W2011991341","https://openalex.org/W2406990460","https://openalex.org/W2040827342","https://openalex.org/W2262044290","https://openalex.org/W2096366696","https://openalex.org/W2055063249","https://openalex.org/W2371314350","https://openalex.org/W1981492719"],"abstract_inverted_index":{"This":[0],"study":[1],"concerns":[2],"the":[3,13,28,51,101,133,136,139,143,147,162,168,195,209],"correlation":[4],"between":[5],"ER":[6],"and":[7,12,54,57,103,156,217],"PR":[8],"status,":[9],"menopausal":[10,157],"status":[11],"effect":[14,82],"of":[15,40,83,105,135,145,149,153,164,170,178,208],"adjuvant":[16,70],"hormonotherapy":[17,150],"in":[18,31,76,87,91,109,151,167,180,199],"high":[19],"risk":[20],"primary":[21],"breast":[22],"cancer":[23],"patients.":[24],"We":[25],"have":[26],"compared":[27],"results":[29],"obtained":[30],"a":[32,41,79,122,182],"randomized":[33],"trial":[34],"(Institut":[35],"Paoli-Calmettes,":[36],"Marseille)":[37],"with":[38,66,99],"those":[39],"historic":[42],"series":[43],"(Centre":[44],"Ren\u00e9":[45],"Huguenin,":[46],"Saint-Cloud).":[47],"The":[48],"patients":[49,67,93,179],"presented":[50],"same":[52],"clinical":[53,218],"histological":[55],"criteria":[56],"received":[58],"identical":[59],"therapeutic":[60,184],"protocols":[61],"(chemotherapy":[62],"and/or":[63],"hormonotherapy).":[64],"Compared":[65],"receiving":[68],"no":[69],"treatment,":[71],"it":[72,190],"appeared":[73,117],"that:":[74],"1)":[75],"post-menopausal":[77],"patients,":[78,89,111],"significant":[80],"detrimental":[81],"tamoxifen":[84],"was":[85,96],"found":[86],"ER-negative":[88],"while":[90],"ER-positive":[92,129],"hormonal":[94,112],"treatment":[95],"well":[97],"correlated":[98],"both":[100],"presence":[102],"level":[104],"steroid":[106],"receptors;":[107],"2)":[108],"pre-menopausal":[110],"therapy":[113,202],"(oophorectomy":[114],"+":[115],"tamoxifen)":[116],"to":[118,172,201],"be":[119,192],"mediated":[120],"by":[121],"complex":[123],"mechanism":[124],"involving":[125],"more":[126],"than":[127],"an":[128],"cell":[130],"population.":[131,197],"In":[132],"light":[134],"published":[137],"results,":[138],"present":[140],"findings":[141],"underline":[142],"importance":[144,163],"reevaluating":[146],"indications":[148],"terms":[152],"hormone":[154],"receptors":[155],"status.":[158],"They":[159,174],"also":[160],"indicate":[161],"biological":[165],"factors":[166],"evaluation":[169],"response":[171,200],"therapy.":[173],"can":[175],"identify,":[176],"subsets":[177,205],"whom":[181],"given":[183],"protocol":[185],"is":[186,206],"detrimental,":[187],"even":[188],"though":[189],"may":[191],"beneficial":[193],"for":[194],"overall":[196],"heterogeneity":[198],"among":[203],"patient":[204],"one":[207],"most":[210],"important":[211],"problems":[212],"which":[213],"confronts":[214],"medical":[215],"statisticians":[216],"investigators.":[219]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
