{"id":"https://openalex.org/W2464036658","doi":"https://doi.org/10.1016/j.chroma.2016.06.084","title":"Mechanistic understanding of fouling of protein A chromatography resin","display_name":"Mechanistic understanding of fouling of protein A chromatography resin","publication_year":2016,"publication_date":"2016-07-03","ids":{"openalex":"https://openalex.org/W2464036658","doi":"https://doi.org/10.1016/j.chroma.2016.06.084","mag":"2464036658","pmid":"https://pubmed.ncbi.nlm.nih.gov/27423774"},"language":"en","primary_location":{"id":"doi:10.1016/j.chroma.2016.06.084","doi":"https://doi.org/10.1016/j.chroma.2016.06.084","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.chroma.2016.06.084","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050862781","display_name":"Mili Pathak","orcid":"https://orcid.org/0000-0002-2384-2468","observed_orcids":["https://orcid.org/0000-0002-2384-2468"]},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mili Pathak","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Technology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Technology, New Delhi, India","institution_ids":["https://openalex.org/I68891433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078008569","display_name":"Anurag Singh Rathore","orcid":"https://orcid.org/0000-0002-5913-4244","observed_orcids":["https://orcid.org/0000-0002-5913-4244"]},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Anurag S. Rathore","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Technology, New Delhi, India. Electronic address: asrathore@biotechcmz.com","Department of Chemical Engineering, Indian Institute of Technology, New Delhi, India"],"raw_orcid":"https://orcid.org/0000-0002-5913-4244","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Technology, New Delhi, India. Electronic address: asrathore@biotechcmz.com","institution_ids":["https://openalex.org/I68891433"]},{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Technology, New Delhi, India","institution_ids":["https://openalex.org/I68891433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078008569"],"corresponding_institution_ids":["https://openalex.org/I68891433"],"apc_list":{"value":4040,"currency":"USD","value_usd":4040},"apc_paid":null,"fwci":1.9087,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.85704642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"1459","issue":null,"first_page":"78","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibody-purification","display_name":"monoclonal antibody purification","score":0.8700000047683716},{"id":"https://openalex.org/keywords/nonspecific-adsorption","display_name":"nonspecific adsorption","score":0.8130000233650208},{"id":"https://openalex.org/keywords/intraparticle-diffusion","display_name":"intraparticle diffusion","score":0.597000002861023},{"id":"https://openalex.org/keywords/mass-transfer-coefficient","display_name":"mass transfer coefficient","score":0.671999990940094},{"id":"https://openalex.org/keywords/ligand-degradation","display_name":"ligand degradation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/particle-porosity","display_name":"particle porosity","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7694742679595947},{"id":"https://openalex.org/C115792997","wikidata":"https://www.wikidata.org/wiki/Q1439803","display_name":"Fouling","level":3,"score":0.6918750405311584},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.613842785358429},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.5338631272315979},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.5268800854682922},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.5074791312217712},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.49241554737091064},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.4173823297023773},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3952372074127197},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.14748644828796387},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11891332268714905},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007526","descriptor_name":"Isoelectric Point","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012117","descriptor_name":"Resins, Synthetic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012117","descriptor_name":"Resins, Synthetic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013205","descriptor_name":"Staphylococcal Protein A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013205","descriptor_name":"Staphylococcal Protein A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.chroma.2016.06.084","doi":"https://doi.org/10.1016/j.chroma.2016.06.084","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.chroma.2016.06.084","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},{"id":"pmid:27423774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27423774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Responsible consumption and production","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/12"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7500320712","display_name":"Creation of a process understanding of chromatographic performance loss during biotherapeutic manufacture: A UK-India partnership","funder_award_id":"EP/K029053/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320336850","display_name":"Centre of Excellence for Biopharmaceutical Technology, Indian Institute of Technology Delhi","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W344661252","https://openalex.org/W1493165623","https://openalex.org/W1582192987","https://openalex.org/W1588865224","https://openalex.org/W1841204415","https://openalex.org/W1887231332","https://openalex.org/W1966258901","https://openalex.org/W1978177075","https://openalex.org/W1981034008","https://openalex.org/W1986991045","https://openalex.org/W1987320912","https://openalex.org/W1989220485","https://openalex.org/W1992816819","https://openalex.org/W2001639946","https://openalex.org/W2006966253","https://openalex.org/W2007469546","https://openalex.org/W2008947460","https://openalex.org/W2031434800","https://openalex.org/W2048504787","https://openalex.org/W2052444922","https://openalex.org/W2058204697","https://openalex.org/W2073348265","https://openalex.org/W2073943480","https://openalex.org/W2074493528","https://openalex.org/W2075460275","https://openalex.org/W2076367767","https://openalex.org/W2076902391","https://openalex.org/W2077500683","https://openalex.org/W2082941728","https://openalex.org/W2088069902","https://openalex.org/W2089816495","https://openalex.org/W2090256228","https://openalex.org/W2094508121","https://openalex.org/W2096313292","https://openalex.org/W2096584421","https://openalex.org/W2097463815","https://openalex.org/W2098137588","https://openalex.org/W2104928881","https://openalex.org/W2109186634","https://openalex.org/W2111845430","https://openalex.org/W2123096590","https://openalex.org/W2137750292","https://openalex.org/W2158732854","https://openalex.org/W2161821835","https://openalex.org/W2171134514","https://openalex.org/W2176564148","https://openalex.org/W2212997086","https://openalex.org/W2478991475","https://openalex.org/W2485759320","https://openalex.org/W2495994052","https://openalex.org/W2547266856","https://openalex.org/W4210584437","https://openalex.org/W4285719527","https://openalex.org/W6721161126"],"related_works":["https://openalex.org/W2884856839","https://openalex.org/W2076902391","https://openalex.org/W2782558389","https://openalex.org/W1841204415","https://openalex.org/W2119437697","https://openalex.org/W2104928881","https://openalex.org/W2948528055","https://openalex.org/W2591101949","https://openalex.org/W2727697624","https://openalex.org/W2975590355"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-07-22T00:00:00"}