{"id":"https://openalex.org/W2463964629","doi":null,"title":"The effects of formulation on the immunostimulatory activity of dihydroheptaprenol.","display_name":"The effects of formulation on the immunostimulatory activity of dihydroheptaprenol.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2463964629","mag":"2463964629","pmid":"https://pubmed.ncbi.nlm.nih.gov/12447843"},"language":"en","primary_location":{"id":"pmid:12447843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12447843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary therapeutics : research in applied veterinary medicine","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043298435","display_name":"James A. Roth","orcid":"https://orcid.org/0000-0003-3562-668X","observed_orcids":["https://orcid.org/0000-0003-3562-668X"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A Roth","raw_affiliation_strings":["Iowa State University, College of Veterinary Medicine, Department of Veterinary Microbiology and Preventive Medicine, Ames, IA 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iowa State University, College of Veterinary Medicine, Department of Veterinary Microbiology and Preventive Medicine, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103340656","display_name":"Beth Hibbard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beth Hibbard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111528772","display_name":"Dagmar \u0395. Frank","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dagmar E Frank","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057994380","display_name":"Lyle D. Kesl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lyle Kesl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090855938","display_name":"Edward J. Robb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward J Robb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.27030992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"3","first_page":"347","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.22609999775886536,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.22609999775886536,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.21330000460147858,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.14169999957084656,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunostimulants","display_name":"immunostimulants","score":0.7739999890327454},{"id":"https://openalex.org/keywords/formulation-effects","display_name":"formulation effects","score":0.6029999852180481},{"id":"https://openalex.org/keywords/miglyol","display_name":"Miglyol","score":0.7730000019073486},{"id":"https://openalex.org/keywords/subcutaneous-administration","display_name":"subcutaneous administration","score":0.8180000185966492},{"id":"https://openalex.org/keywords/intranasal-administration","display_name":"intranasal administration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neutrophil-function","display_name":"neutrophil function","score":0.5210000276565552},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.777999997138977},{"id":"https://openalex.org/keywords/body-temperature","display_name":"body temperature","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6783583760261536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6720768213272095},{"id":"https://openalex.org/C2779564620","wikidata":"https://www.wikidata.org/wiki/Q241595","display_name":"Lecithin","level":2,"score":0.6093546152114868},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4581005871295929},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4048304855823517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20756900310516357}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003574","descriptor_name":"Cytochrome c Group","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004655","descriptor_name":"Emulsions","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018375","descriptor_name":"Neutrophil Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12447843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12447843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary therapeutics : research in applied veterinary medicine","raw_type":"Clinical Trial"},{"id":"mag:2463964629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12447843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W145168283","https://openalex.org/W1943399209","https://openalex.org/W2004263247","https://openalex.org/W2009872401","https://openalex.org/W2057727500","https://openalex.org/W2058580590","https://openalex.org/W2061715387","https://openalex.org/W2312429505","https://openalex.org/W2315594377"],"related_works":["https://openalex.org/W2039788612","https://openalex.org/W2253211603","https://openalex.org/W135855443","https://openalex.org/W2522337922","https://openalex.org/W2039594393","https://openalex.org/W7146747411","https://openalex.org/W1970430777","https://openalex.org/W82177955","https://openalex.org/W2149655114","https://openalex.org/W3011023376"],"abstract_inverted_index":{"Holstein":[0],"steer":[1],"calves":[2],"received":[3],"a":[4,15,51],"single":[5],"injection":[6],"of":[7,76,91,103,113],"Miglyol":[8,29,38,86],"(Sasol":[9],"Chemical":[10],"Industries,":[11],"Ltd.)":[12],"subcutaneously":[13,49,96],"as":[14],"placebo,":[16],"dihydroheptaprenol":[17],"(DHP)":[18],"(4":[19,30,39],"mg/kg)":[20,31,40],"emulsified":[21,44],"with":[22],"lecithin":[23,46],"subcutaneously,":[24,32],"DHP":[25,34,43,83,104],"in":[26,28,35,37,45,54,85],"solution":[27,36],"or":[33,97],"intranasally.":[41,98],"The":[42,82,99],"emulsion":[47],"administered":[48,95],"caused":[50],"substantial":[52],"increase":[53],"body":[55],"temperature,":[56],"total":[57,60],"leukocyte":[58],"count,":[59,62],"neutrophil":[61,63,67],"cytochrome-c":[64],"reduction,":[65],"and":[66,101],"iodination":[68],"24":[69],"hours":[70],"after":[71],"administration":[72],"and,":[73],"for":[74],"some":[75],"the":[77,110],"parameters,":[78],"at":[79],"48":[80],"hours.":[81],"formulation":[84,102],"did":[87],"not":[88],"have":[89,106],"any":[90],"these":[92],"effects":[93,108],"when":[94],"carrier":[100],"apparently":[105],"major":[107],"on":[109],"biologic":[111],"activity":[112],"DHP.":[114]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
