{"id":"https://openalex.org/W2463858784","doi":null,"title":"Efficiency of gentamicin loaded in bacterial polysaccharides microcapsules against intracellular Gram-positive and Gram-negative invasive pathogens.","display_name":"Efficiency of gentamicin loaded in bacterial polysaccharides microcapsules against intracellular Gram-positive and Gram-negative invasive pathogens.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2463858784","mag":"2463858784","pmid":"https://pubmed.ncbi.nlm.nih.gov/26743289"},"language":"en","primary_location":{"id":"pmid:26743289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26743289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042005786","display_name":"Croitoru Cd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61641377","display_name":"Universitatea Na\u021bional\u0103 de \u0218tiin\u021b\u0103 \u0219i Tehnologie Politehnica Bucure\u0219ti","ror":"https://ror.org/0558j5q12","country_code":"RO","type":"education","lineage":["https://openalex.org/I61641377"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Cristina Doina Croitoru","raw_affiliation_strings":["Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania; danedmih@gmail.com","Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania; danedmih@gmail.com","institution_ids":["https://openalex.org/I61641377"]},{"raw_affiliation_string":"Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania","institution_ids":["https://openalex.org/I61641377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035496604","display_name":"Dan Eduard Mih\u0103iescu","orcid":"https://orcid.org/0000-0001-9873-3912","observed_orcids":["https://orcid.org/0000-0001-9873-3912"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Eduard Mihaiescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001059217","display_name":"Mariana Carmen Chifiriuc","orcid":"https://orcid.org/0000-0001-6098-1857","observed_orcids":["https://orcid.org/0000-0001-6098-1857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariana Carmen Chifiriuc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114125287","display_name":"Alexandra Bolocan","orcid":"https://orcid.org/0000-0003-2880-6922","observed_orcids":["https://orcid.org/0000-0003-2880-6922"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Bolocan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037454823","display_name":"Coralia Bleo\u0163u","orcid":"https://orcid.org/0000-0002-9031-338X","observed_orcids":["https://orcid.org/0000-0002-9031-338X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Coralia Bleotu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029913928","display_name":"Grumezescu Am","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandru Mihai Grumezescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090239925","display_name":"Crina Maria Saviuc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Crina Maria Saviuc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112168645","display_name":"Veronica Laz\u0103r","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veronica Laz\u0103r","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018191349","display_name":"Carmen Curu\u021biu","orcid":"https://orcid.org/0000-0002-4608-4487","observed_orcids":["https://orcid.org/0000-0002-4608-4487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Curu\u0163iu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"56","issue":"4","first_page":"1417","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.22030000388622284,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":1.0},{"id":"https://openalex.org/keywords/bacterial-polysaccharides","display_name":"bacterial polysaccharides","score":0.9750000238418579},{"id":"https://openalex.org/keywords/microcapsules","display_name":"microcapsules","score":0.9819999933242798},{"id":"https://openalex.org/keywords/intracellular-drug-delivery","display_name":"intracellular drug delivery","score":0.9350000023841858},{"id":"https://openalex.org/keywords/intracellular-infection","display_name":"intracellular infection","score":0.6449999809265137},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":1.0},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.9160000085830688},{"id":"https://openalex.org/keywords/polymeric-drug-delivery","display_name":"polymeric drug delivery","score":0.7590000033378601},{"id":"https://openalex.org/keywords/targeted-release","display_name":"targeted release","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.8785128593444824},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.8363244533538818},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.72043776512146},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6607848405838013},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6404439210891724},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.48188239336013794},{"id":"https://openalex.org/C161369605","wikidata":"https://www.wikidata.org/wiki/Q41803","display_name":"Gram","level":3,"score":0.4728073179721832},{"id":"https://openalex.org/C2776051709","wikidata":"https://www.wikidata.org/wiki/Q632006","display_name":"Gram-negative bacteria","level":4,"score":0.4317835569381714},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4010125398635864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37862086296081543},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.35664358735084534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17951354384422302},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.10272637009620667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:26743289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26743289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","raw_type":"Journal Article"},{"id":"mag:2463858784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26743289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W104933661","https://openalex.org/W1526922847","https://openalex.org/W1971863203","https://openalex.org/W1976600818","https://openalex.org/W1977711966","https://openalex.org/W1996697333","https://openalex.org/W2010502870","https://openalex.org/W2013754028","https://openalex.org/W2015720649","https://openalex.org/W2026457034","https://openalex.org/W2045136590","https://openalex.org/W2045523528","https://openalex.org/W2052489968","https://openalex.org/W2059937737","https://openalex.org/W2062835892","https://openalex.org/W2063536646","https://openalex.org/W2064809559","https://openalex.org/W2067673936","https://openalex.org/W2076387592","https://openalex.org/W2096629830","https://openalex.org/W2102029922","https://openalex.org/W2102900787","https://openalex.org/W2112561464","https://openalex.org/W2120022730","https://openalex.org/W2238342433","https://openalex.org/W2274780378"],"related_works":["https://openalex.org/W2063536646","https://openalex.org/W4393279587","https://openalex.org/W2030358722","https://openalex.org/W4206682938","https://openalex.org/W2101964492","https://openalex.org/W2102900787","https://openalex.org/W2062263525","https://openalex.org/W1971863203","https://openalex.org/W2132075442","https://openalex.org/W2285061384"],"abstract_inverted_index":{"Gentamicin":[0],"is":[1],"an":[2,31,87],"aminoglycoside":[3],"antibiotic":[4],"with":[5],"a":[6],"wide":[7],"spectrum":[8],"of":[9,37,53,61,67,96],"anti-bacterial":[10],"activity,":[11],"but":[12],"however,":[13],"due":[14],"to":[15,76],"its":[16],"high":[17],"solubility":[18],"in":[19,64],"water,":[20],"it":[21],"poorly":[22],"penetrates":[23],"inside":[24],"the":[25,35,50,54,58,65,69,93],"cells.":[26],"This":[27,84],"major":[28],"inconvenient":[29],"constitutes":[30],"important":[32],"challenge":[33],"for":[34,49,92],"treatment":[36],"intracellular":[38,59,82,94],"bacterial":[39,100],"infections,":[40],"which":[41],"might":[42],"be":[43],"solved":[44],"using":[45],"appropriate":[46],"delivery":[47,72,90],"systems":[48,73],"targeted":[51],"release":[52,95],"bioactive":[55],"agents":[56],"at":[57],"sites":[60],"infection.":[62],"Thus,":[63],"case":[66],"antibiotics,":[68],"use":[70],"drug":[71],"may":[74],"contribute":[75],"increase":[77],"their":[78],"therapeutic":[79],"activity":[80],"against":[81],"pathogens.":[83],"paper":[85],"presents":[86],"efficient":[88],"polymeric":[89],"system":[91],"gentamicin":[97],"based":[98],"on":[99],"polysaccharides.":[101]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}