{"id":"https://openalex.org/W2463735202","doi":null,"title":"(sterol balance/cholesterol synthesis/bile acid synthesis/plasma lipi","display_name":"(sterol balance/cholesterol synthesis/bile acid synthesis/plasma lipi","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2463735202","mag":"2463735202"},"language":"en","primary_location":{"id":"mag:2463735202","doi":null,"is_oa":false,"landing_page_url":"https://www.jstor.org/stable/13651","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113560936","display_name":"Donald J. McNamara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald J. McNamara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058341893","display_name":"Clinton D. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clinton D. Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047722061","display_name":"Thomas S. Parker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas S. Parker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09160168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.058400001376867294,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/portocaval-anastomosis","display_name":"portacaval anastomosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/bile-acid-synthesis","display_name":"bile acid synthesis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.871999979019165},{"id":"https://openalex.org/keywords/serum-bile-acids","display_name":"serum bile acids","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.37700000405311584},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7998073697090149},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7414689064025879},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6849112510681152},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.5800835490226746},{"id":"https://openalex.org/C3017755632","wikidata":"https://www.wikidata.org/wiki/Q14913010","display_name":"Cholesterol synthesis","level":4,"score":0.48464304208755493},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.48381489515304565},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46751075983047485},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.4433337450027466},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.4382627308368683},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3666059374809265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3491418957710266},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.23648077249526978},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14712494611740112},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12595444917678833},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.11956402659416199},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2463735202","doi":null,"is_oa":false,"landing_page_url":"https://www.jstor.org/stable/13651","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2118313918"],"related_works":["https://openalex.org/W1972088252","https://openalex.org/W2101816307","https://openalex.org/W7009323738","https://openalex.org/W2114205827","https://openalex.org/W2093965367","https://openalex.org/W2055033457","https://openalex.org/W2397889695","https://openalex.org/W2083733543","https://openalex.org/W2040195812","https://openalex.org/W1982757068"],"abstract_inverted_index":{"Measurements":[0],"of":[1,5,12,16,55,66,81,98,107,140,162],"the":[2,10,13,48,52,63,91,151,167],"key":[3],"parameters":[4],"choles-":[6],"terol":[7],"homeostasis":[8,188],"and":[9,31,35,37,57,62,70,94,116,124,130,180,189],"mass":[11],"body":[14,68,99],"pools":[15],"cholesterol":[17,61,69,187],"were":[18],"carried":[19],"out":[20],"in":[21,90,111,154,177],"two":[22],"patients":[23,47,115,118],"with":[24],"familial":[25],"hypercholesterol-":[26],"emia":[27],"(FH),":[28],"one":[29,32],"homozygote":[30],"heterozygote,":[33],"before":[34,129],"28":[36],"18":[38],"months,":[39],"respectively,":[40],"after":[41,121,131],"portacaval":[42],"anastomosis":[43],"(PCA).":[44],"In":[45,74,166],"both":[46,155],"procedure":[49],"significantly":[50],"reduced":[51],"plasma":[53,127],"concentrations":[54],"total":[56,95],"low":[58],"density":[59],"lipoprotein":[60],"daily":[64],"rate":[65],"whole":[67],"bile":[71,109],"acid":[72],"synthesis.":[73],"addition,":[75],"PCA":[76],"caused":[77],"a":[78,122,136,174],"net":[79],"efflux":[80],"accumulated":[82],"tissue":[83],"cho-":[84],"lesterol":[85],"as":[86],"demonstrated":[87],"by":[88,105,125],"reductions":[89],"rapidly":[92],"exchangeable":[93,96],"masses":[97],"cholesterol.":[100],"Shunt":[101],"patency":[102],"was":[103],"verified":[104],"demonstration":[106],"increased":[108,126,138],"acids":[110],"serum":[112,141],"from":[113,117],"fasting":[114],"2":[119],"hr":[120],"meal":[123],"glucagon":[128],"arginine":[132],"infusion.":[133],"Other":[134],"than":[135],"persistently":[137],"level":[139],"alkaline":[142],"phos-":[143],"phatase,":[144],"liver":[145],"function":[146],"tests":[147],"have":[148],"fallen":[149],"within":[150],"normal":[152],"range":[153],"patients;":[156],"there":[157,170],"has":[158,171],"been":[159,173],"no":[160],"evidence":[161],"hepatic":[163],"encepha-":[164],"lopathy.":[165],"homozygous":[168],"patient":[169],"also":[172],"striking":[175],"resolution":[176],"xanthoma":[178],"size":[179],"distribution.":[181],"These":[182],"multiple":[183],"ef-":[184],"fects":[185],"on":[186],"pool":[190],"sizes":[191],"strongly":[192],"suggest":[193]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-07-22T00:00:00"}