{"id":"https://openalex.org/W2463671312","doi":"https://doi.org/10.1097/00007611-198712000-00008","title":"Limited Stage Small Cell Lung Cancer: Analysis of Clinical Prognostic Factors","display_name":"Limited Stage Small Cell Lung Cancer: Analysis of Clinical Prognostic Factors","publication_year":1987,"publication_date":"1987-12-01","ids":{"openalex":"https://openalex.org/W2463671312","doi":"https://doi.org/10.1097/00007611-198712000-00008","mag":"2463671312","pmid":"https://pubmed.ncbi.nlm.nih.gov/2827319"},"language":"en","primary_location":{"id":"doi:10.1097/00007611-198712000-00008","doi":"https://doi.org/10.1097/00007611-198712000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007611-198712000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S89143414","display_name":"Southern Medical Journal","issn_l":"0038-4348","issn":["0038-4348","1541-8243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Southern Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065917441","display_name":"John Daniel Hainsworth","orcid":"https://orcid.org/0000-0002-2848-6546","observed_orcids":["https://orcid.org/0000-0002-2848-6546"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN D. HAINSWORTH","raw_affiliation_strings":["Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn","Vanderbilt University,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University,#TAB#","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707106","display_name":"David H. Johnson","orcid":"https://orcid.org/0000-0001-6851-6888","observed_orcids":["https://orcid.org/0000-0001-6851-6888"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID H. JOHNSON","raw_affiliation_strings":["Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083674919","display_name":"Robert V. Farese","orcid":"https://orcid.org/0000-0001-8103-2239","observed_orcids":["https://orcid.org/0000-0001-8103-2239"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT V. FARESE","raw_affiliation_strings":["Vanderbilt University,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University,#TAB#","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112182842","display_name":"JODY W. MACEY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JODY W. MACEY","raw_affiliation_strings":["Vanderbilt University,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University,#TAB#","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108500409","display_name":"William K. Vaughn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WILLIAM K. VAUGHN","raw_affiliation_strings":["Vanderbilt University,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University,#TAB#","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073724595","display_name":"F. Anthony Greco","orcid":"https://orcid.org/0009-0009-4578-0630","observed_orcids":["https://orcid.org/0009-0009-4578-0630"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F ANTHONY GRECO","raw_affiliation_strings":["Vanderbilt University,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University,#TAB#","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":0.1934,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61291111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"80","issue":"12","first_page":"1518","last_page":"1522"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limited-stage-small-cell-lung-cancer","display_name":"limited-stage small cell lung cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/serum-lactate-dehydrogenase","display_name":"serum lactate dehydrogenase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6290000081062317},{"id":"https://openalex.org/keywords/tumor-volume","display_name":"tumor volume","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tnm-staging","display_name":"TNM staging","score":0.8949999809265137},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7879999876022339},{"id":"https://openalex.org/keywords/chest-radiotherapy","display_name":"chest radiotherapy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.8169999718666077},{"id":"https://openalex.org/keywords/chest-x-ray","display_name":"chest radiography","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9710178375244141},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.7916845679283142},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.6728617548942566},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6723632216453552},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.6329278349876404},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6082507371902466},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5994365811347961},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5205087065696716},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49181655049324036},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4666082262992859},{"id":"https://openalex.org/C2776808855","wikidata":"https://www.wikidata.org/wiki/Q668115","display_name":"TNM staging system","level":4,"score":0.4455733597278595},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.43584078550338745},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4228241443634033},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.41543954610824585},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3642398715019226},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36263519525527954},{"id":"https://openalex.org/C3018130915","wikidata":"https://www.wikidata.org/wiki/Q1752284","display_name":"Neoplasm staging","level":3,"score":0.1776614487171173},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000206","descriptor_name":"Actuarial Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007611-198712000-00008","doi":"https://doi.org/10.1097/00007611-198712000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007611-198712000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S89143414","display_name":"Southern Medical Journal","issn_l":"0038-4348","issn":["0038-4348","1541-8243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Southern Medical Journal","raw_type":"journal-article"},{"id":"pmid:2827319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2827319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Southern medical journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G303821068","display_name":null,"funder_award_id":"CA-23909","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3317173391","display_name":null,"funder_award_id":"CA19429","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2076909735","https://openalex.org/W2051493536","https://openalex.org/W99964112","https://openalex.org/W2032994615","https://openalex.org/W1822569953","https://openalex.org/W2027885836","https://openalex.org/W2372270965","https://openalex.org/W2168585061","https://openalex.org/W2372006656","https://openalex.org/W2297260483"],"abstract_inverted_index":{"In":[0],"an":[1,117],"attempt":[2],"to":[3,110,159],"identify":[4],"clinical":[5,105],"features":[6],"of":[7,27,44,77,81,116],"prognostic":[8,114],"value":[9],"in":[10,132],"patients":[11,30,37,60,143],"with":[12,40,47,144],"limited":[13,145],"stage":[14,107,146],"small":[15,138,147],"cell":[16,139,148],"lung":[17,140,149],"cancer,":[18],"we":[19,127],"retrospectively":[20],"reviewed":[21],"the":[22,58,64,75,113,133],"records":[23],"and":[24,87,104],"chest":[25,50,102],"roentgenograms":[26],"101":[28,59],"such":[29],"seen":[31],"at":[32,74],"Vanderbilt":[33],"University":[34],"Hospital.":[35],"All":[36],"were":[38,108],"treated":[39,161],"combination":[41],"chemotherapy":[42],"regimens":[43],"comparable":[45],"efficacy":[46],"or":[48],"without":[49],"radiotherapy":[51],"and/or":[52],"surgical":[53],"resection.":[54],"Median":[55],"survival":[56,67,83],"for":[57,136],"was":[61,68,79],"16":[62],"months;":[63],"three-year":[65],"actuarial":[66],"14%.":[69],"Elevated":[70],"serum":[71,119],"LDH":[72,120],"level":[73,121],"time":[76],"diagnosis":[78],"predictive":[80],"improved":[82],"by":[84,124],"both":[85],"univariate":[86],"multivariate":[88],"analyses":[89],"(P":[90],"less":[91],"than":[92],".01).":[93],"Initial":[94],"tumor":[95,99],"volume":[96],"(calculated":[97],"from":[98],"measurements)":[100],"on":[101],"roentgenogram":[103],"TNM":[106],"unrelated":[109],"survival.":[111],"Until":[112],"significance":[115],"elevated":[118],"is":[122],"confirmed":[123],"other":[125],"investigators,":[126],"cannot":[128],"recommend":[129],"any":[130],"modification":[131],"current":[134],"system":[135],"staging":[137],"cancer.":[141],"Although":[142],"cancer":[150],"form":[151],"a":[152],"clinically":[153],"heterogeneous":[154],"group,":[155],"they":[156],"should":[157],"continue":[158],"be":[160],"uniformly.":[162]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}