{"id":"https://openalex.org/W2463374292","doi":null,"title":"Determinants of vascular responsiveness to endogenous and exogenous activators of guanylate cyclases","display_name":"Determinants of vascular responsiveness to endogenous and exogenous activators of guanylate cyclases","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2463374292","mag":"2463374292"},"language":"en","primary_location":{"id":"mag:2463374292","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/428008","pdf_url":null,"source":{"id":"https://openalex.org/S4306508234","display_name":"Doctoral thesis, University of London.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, University of London.","raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032270108","display_name":"Abdulmonim A. Alqasim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Abdulmonim A. Alqasim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5032270108"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase","display_name":"soluble guanylate cyclase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/particulate-guanylyl-cyclase","display_name":"particulate guanylate cyclase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/s-nitrosothiols","display_name":"S-nitrosothiols","score":0.8579999804496765},{"id":"https://openalex.org/keywords/s-nitrosoglutathione","display_name":"S-nitrosoglutathione","score":0.8700000047683716},{"id":"https://openalex.org/keywords/s-nitrosocysteine","display_name":"S-nitrosocysteine","score":0.8259999752044678},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.5590000152587891},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cgmp-signaling","display_name":"cGMP signaling","score":0.574999988079071},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6299999952316284},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.7099999785423279},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.6959999799728394},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.40400001406669617},{"id":"https://openalex.org/keywords/camp-pathway","display_name":"cAMP pathway","score":0.45399999618530273},{"id":"https://openalex.org/keywords/1400w","display_name":"1400W","score":0.7670000195503235},{"id":"https://openalex.org/keywords/odq","display_name":"ODQ","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7961841225624084},{"id":"https://openalex.org/C2778827303","wikidata":"https://www.wikidata.org/wiki/Q7558945","display_name":"Soluble guanylyl cyclase","level":4,"score":0.6716537475585938},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6701012253761292},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.586891233921051},{"id":"https://openalex.org/C173803235","wikidata":"https://www.wikidata.org/wiki/Q419566","display_name":"Guanylate cyclase","level":3,"score":0.5081207752227783},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4778599143028259},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46081963181495667},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4452284872531891},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.44069749116897583},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4371485412120819},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.43294116854667664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2897336483001709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17651531100273132},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1379794478416443},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2463374292","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/428008","pdf_url":null,"source":{"id":"https://openalex.org/S4306508234","display_name":"Doctoral thesis, University of London.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, University of London.","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":312,"referenced_works":["https://openalex.org/W36502835","https://openalex.org/W98022268","https://openalex.org/W105256667","https://openalex.org/W304581165","https://openalex.org/W1485515329","https://openalex.org/W1488493608","https://openalex.org/W1509418264","https://openalex.org/W1517162073","https://openalex.org/W1520395487","https://openalex.org/W1525159534","https://openalex.org/W1533077678","https://openalex.org/W1552116007","https://openalex.org/W1557787993","https://openalex.org/W1574035164","https://openalex.org/W1579903794","https://openalex.org/W1591881963","https://openalex.org/W1607672162","https://openalex.org/W1653586985","https://openalex.org/W1663110680","https://openalex.org/W1678800844","https://openalex.org/W1741421471","https://openalex.org/W1749352888","https://openalex.org/W1776160697","https://openalex.org/W1800678382","https://openalex.org/W1835367657","https://openalex.org/W1860372928","https://openalex.org/W1866791144","https://openalex.org/W1872105221","https://openalex.org/W1876188113","https://openalex.org/W1911698486","https://openalex.org/W1963934554","https://openalex.org/W1964105983","https://openalex.org/W1964186367","https://openalex.org/W1964996063","https://openalex.org/W1965709392","https://openalex.org/W1966149617","https://openalex.org/W1966736088","https://openalex.org/W1966985035","https://openalex.org/W1968740258","https://openalex.org/W1969920863","https://openalex.org/W1970040046","https://openalex.org/W1970382485","https://openalex.org/W1970407496","https://openalex.org/W1970737985","https://openalex.org/W1972331465","https://openalex.org/W1972952055","https://openalex.org/W1973133531","https://openalex.org/W1973880098","https://openalex.org/W1974037978","https://openalex.org/W1976324923","https://openalex.org/W1977392344","https://openalex.org/W1979004076","https://openalex.org/W1981193930","https://openalex.org/W1981729604","https://openalex.org/W1982270701","https://openalex.org/W1982990573","https://openalex.org/W1983311124","https://openalex.org/W1984728211","https://openalex.org/W1985330055","https://openalex.org/W1986119723","https://openalex.org/W1986542934","https://openalex.org/W1987660378","https://openalex.org/W1988232724","https://openalex.org/W1989792368","https://openalex.org/W1989912677","https://openalex.org/W1990119007","https://openalex.org/W1990134662","https://openalex.org/W1990484070","https://openalex.org/W1991347361","https://openalex.org/W1992526945","https://openalex.org/W1992983801","https://openalex.org/W1993161617","https://openalex.org/W1993387626","https://openalex.org/W1993827632","https://openalex.org/W1994684915","https://openalex.org/W1995721699","https://openalex.org/W1996000832","https://openalex.org/W1998143238","https://openalex.org/W1998344524","https://openalex.org/W1998361708","https://openalex.org/W1998465616","https://openalex.org/W2000344463","https://openalex.org/W2000881220","https://openalex.org/W2002019101","https://openalex.org/W2003396590","https://openalex.org/W2003749942","https://openalex.org/W2003913161","https://openalex.org/W2005011308","https://openalex.org/W2005377232","https://openalex.org/W2006172842","https://openalex.org/W2006641024","https://openalex.org/W2006705030","https://openalex.org/W2006958729","https://openalex.org/W2007419421","https://openalex.org/W2007737411","https://openalex.org/W2010489806","https://openalex.org/W2010783235","https://openalex.org/W2011274722","https://openalex.org/W2011582460","https://openalex.org/W2011632934","https://openalex.org/W2011920764","https://openalex.org/W2012039654","https://openalex.org/W2012479103","https://openalex.org/W2012978126","https://openalex.org/W2013628401","https://openalex.org/W2014436670","https://openalex.org/W2015853348","https://openalex.org/W2015960226","https://openalex.org/W2016353114","https://openalex.org/W2016386992","https://openalex.org/W2017706062","https://openalex.org/W2018555496","https://openalex.org/W2018992923","https://openalex.org/W2019613587","https://openalex.org/W2020496288","https://openalex.org/W2021117769","https://openalex.org/W2021867660","https://openalex.org/W2022617325","https://openalex.org/W2023170094","https://openalex.org/W2024130943","https://openalex.org/W2025204457","https://openalex.org/W2027038969","https://openalex.org/W2027874441","https://openalex.org/W2028214912","https://openalex.org/W2029096127","https://openalex.org/W2029157767","https://openalex.org/W2029487004","https://openalex.org/W2029583951","https://openalex.org/W2030039340","https://openalex.org/W2030345435","https://openalex.org/W2030495727","https://openalex.org/W2030864821","https://openalex.org/W2031954531","https://openalex.org/W2032327660","https://openalex.org/W2032825410","https://openalex.org/W2033240573","https://openalex.org/W2034773285","https://openalex.org/W2036213369","https://openalex.org/W2036564332","https://openalex.org/W2037034485","https://openalex.org/W2038299223","https://openalex.org/W2038600714","https://openalex.org/W2040072601","https://openalex.org/W2040236756","https://openalex.org/W2040345537","https://openalex.org/W2041075406","https://openalex.org/W2042297383","https://openalex.org/W2042531223","https://openalex.org/W2043237554","https://openalex.org/W2043583232","https://openalex.org/W2043863070","https://openalex.org/W2044263892","https://openalex.org/W2044555799","https://openalex.org/W2045138089","https://openalex.org/W2046160656","https://openalex.org/W2047401628","https://openalex.org/W2048635427","https://openalex.org/W2048756826","https://openalex.org/W2049157359","https://openalex.org/W2049472065","https://openalex.org/W2049505174","https://openalex.org/W2051357753","https://openalex.org/W2051923022","https://openalex.org/W2052391094","https://openalex.org/W2052874321","https://openalex.org/W2052966837","https://openalex.org/W2053572332","https://openalex.org/W2054589903","https://openalex.org/W2054704457","https://openalex.org/W2054802842","https://openalex.org/W2054935021","https://openalex.org/W2055875581","https://openalex.org/W2055945712","https://openalex.org/W2057454756","https://openalex.org/W2058494523","https://openalex.org/W2058520514","https://openalex.org/W2060243949","https://openalex.org/W2061628171","https://openalex.org/W2062445457","https://openalex.org/W2063078080","https://openalex.org/W2063477254","https://openalex.org/W2063650074","https://openalex.org/W2064061480","https://openalex.org/W2064568027","https://openalex.org/W2065796067","https://openalex.org/W2066231048","https://openalex.org/W2066306348","https://openalex.org/W2067106162","https://openalex.org/W2067663390","https://openalex.org/W2068847639","https://openalex.org/W2070042140","https://openalex.org/W2071348092","https://openalex.org/W2072376419","https://openalex.org/W2072923057","https://openalex.org/W2073269022","https://openalex.org/W2075422765","https://openalex.org/W2075842226","https://openalex.org/W2076142664","https://openalex.org/W2077193676","https://openalex.org/W2077619217","https://openalex.org/W2078331312","https://openalex.org/W2079047912","https://openalex.org/W2079756417","https://openalex.org/W2081394289","https://openalex.org/W2082232204","https://openalex.org/W2082402917","https://openalex.org/W2083013409","https://openalex.org/W2084077120","https://openalex.org/W2085742386","https://openalex.org/W2085823269","https://openalex.org/W2085936016","https://openalex.org/W2086349553","https://openalex.org/W2086474844","https://openalex.org/W2086938836","https://openalex.org/W2087947412","https://openalex.org/W2088164373","https://openalex.org/W2088567432","https://openalex.org/W2090700025","https://openalex.org/W2091138507","https://openalex.org/W2091193879","https://openalex.org/W2091699830","https://openalex.org/W2092091468","https://openalex.org/W2092145002","https://openalex.org/W2092478589","https://openalex.org/W2092643965","https://openalex.org/W2092884273","https://openalex.org/W2093436690","https://openalex.org/W2093518775","https://openalex.org/W2094945284","https://openalex.org/W2095115132","https://openalex.org/W2095686650","https://openalex.org/W2099312302","https://openalex.org/W2100904403","https://openalex.org/W2101593001","https://openalex.org/W2102153963","https://openalex.org/W2102446343","https://openalex.org/W2105297145","https://openalex.org/W2105657039","https://openalex.org/W2106104578","https://openalex.org/W2106403873","https://openalex.org/W2107031234","https://openalex.org/W2107429652","https://openalex.org/W2108576089","https://openalex.org/W2109115943","https://openalex.org/W2110524653","https://openalex.org/W2110648119","https://openalex.org/W2112656429","https://openalex.org/W2114425457","https://openalex.org/W2114939565","https://openalex.org/W2115631902","https://openalex.org/W2118571849","https://openalex.org/W2121415692","https://openalex.org/W2122414904","https://openalex.org/W2122515902","https://openalex.org/W2122702212","https://openalex.org/W2124823399","https://openalex.org/W2125804349","https://openalex.org/W2126215854","https://openalex.org/W2127317699","https://openalex.org/W2127398792","https://openalex.org/W2127466966","https://openalex.org/W2127778217","https://openalex.org/W2128725121","https://openalex.org/W2129968983","https://openalex.org/W2131010086","https://openalex.org/W2131475757","https://openalex.org/W2132343702","https://openalex.org/W2132867842","https://openalex.org/W2133335467","https://openalex.org/W2135990684","https://openalex.org/W2138676060","https://openalex.org/W2139088949","https://openalex.org/W2140402513","https://openalex.org/W2141627184","https://openalex.org/W2145236256","https://openalex.org/W2148392011","https://openalex.org/W2149429779","https://openalex.org/W2150616706","https://openalex.org/W2151785608","https://openalex.org/W2152511204","https://openalex.org/W2153684319","https://openalex.org/W2153889396","https://openalex.org/W2155791167","https://openalex.org/W2155817807","https://openalex.org/W2156120690","https://openalex.org/W2156597317","https://openalex.org/W2163351732","https://openalex.org/W2163917074","https://openalex.org/W2164116069","https://openalex.org/W2166389885","https://openalex.org/W2168456131","https://openalex.org/W2169182236","https://openalex.org/W2182235855","https://openalex.org/W2222120722","https://openalex.org/W2244280198","https://openalex.org/W2262423141","https://openalex.org/W2274462768","https://openalex.org/W2328167306","https://openalex.org/W2329935615","https://openalex.org/W2331323381","https://openalex.org/W2332065384","https://openalex.org/W2345171431","https://openalex.org/W2397508357","https://openalex.org/W2403195379","https://openalex.org/W2405690953","https://openalex.org/W2410806076","https://openalex.org/W2414532444","https://openalex.org/W2416197427","https://openalex.org/W2417742131","https://openalex.org/W2419332938","https://openalex.org/W2467657054","https://openalex.org/W2467680689"],"related_works":["https://openalex.org/W1987453762","https://openalex.org/W1986037233","https://openalex.org/W3166924265","https://openalex.org/W7096468182","https://openalex.org/W2108555530","https://openalex.org/W7070739522","https://openalex.org/W2166122472","https://openalex.org/W2031250144","https://openalex.org/W2115716309","https://openalex.org/W1940266882"],"abstract_inverted_index":{"This":[0,199],"thesis":[1],"describes":[2],"studies":[3],"to":[4,153,165,186,203,218,317],"investigate":[5,277],"the":[6,21,37,85,103,128,131,140,207,225,278,319],"regulation":[7,22],"of":[8,23,39,48,66,88,105,130,214,232,261,280,284,290,321,325,337,347,359,371],"guanylate":[9,25,361],"cyclases":[10],"pathways":[11,205],"in":[12,20,155,269],"blood":[13],"vessels.":[14,157],"Endogenous":[15],"iS-nitrosothiols":[16],"have":[17],"been":[18],"implicated":[19],"soluble":[24],"cyclase":[26],"(sGC),":[27],"by":[28,41,70,108,197,258,271,330,335,351],"modulating":[29],"nitric":[30],"oxide":[31],"(NO)":[32],"bioactivity.":[33],"To":[34,276],"determine":[35],"whether":[36],"biotransformation":[38],"S-nitrosothiols":[40],"isolated":[42],"rat":[43,79,114],"aorta":[44,80,115],"is":[45,201,216,265],"enzyme-dependent,":[46],"stereoisomers":[47,69,90,107],"S-nitrosoglutathione":[49],"(GSNO),":[50],"S-nitrosocysteine":[51],"(CYSNO)":[52],"and":[53,58,61,113,117,137,179,273,286,297,305,311,327,355,362,373],"5-mtroso-N-acetyl-pemcillamine":[54],"(SNAP)":[55],"were":[56,315],"synthesised":[57],"their":[59,120],"decomposition":[60,104],"relaxant":[62,121],"effects":[63,122],"characterised.":[64],"Decomposition":[65],"these":[67,322,338],"S-nitrosothiol":[68],"Cu(I),":[71,109],"Cu(II),":[72,110],"Cu/Zn":[73,111],"superoxide":[74,308],"dismutase":[75],"(Cu/Zn":[76],"SOD)":[77],"or":[78,149,237],"was":[81,91,210,227,333],"equivalent":[82],"(P>0.05).":[83,93],"Similarly,":[84],"vasorelaxant":[86],"activity":[87],"iS-nitrosothiol":[89],"equipotent":[92],"The":[94,212],"selective":[95],"Cu(I)":[96],"chelator,":[97],"bathocuproine":[98],"disulfonic":[99],"acid":[100,304],"(BCS),":[101],"blocked":[102],"5-nitrosothiol":[106],"SOD":[112],"(PO.05)":[116],"significantly":[118],"inhibited":[119],"(P":[123],"0.05).":[124],"LPS":[125,172,343],"also":[126,161],"reduced":[127],"potency":[129],"pGC":[132,180],"activators":[133],"C-type":[134],"natriuretic":[135],"peptide":[136],"ANP.":[138],"1400W,":[139],"sGC":[141,178,285,372],"inhibitor":[142],"1H-":[143],"l,2,4":[144],"Oxadiazolo":[145],"4,3-a":[146],"quinoxalin-l-one":[147],"(ODQ)":[148],"both,":[150],"preserved":[151,379],"relaxations":[152],"ANP":[154,166],"LPS-treated":[156],"1400W":[158],"and/or":[159],"ODQ":[160],"reversed":[162],"established":[163],"desensitisation":[164,215,283,358,370],"within":[167],"minutes":[168],"(all":[169,340],"PO.05":[170],"versus":[171,342],"alone).":[173,344],"These":[174,241],"results":[175],"indicate":[176],"that":[177,244,264],"signalling":[181],"are":[182,256],"desensitised":[183],"following":[184,230],"exposure":[185],"LPS,":[187],"consistent":[188],"with":[189,249],"a":[190,220],"compensatory":[191],"mechanism":[192,213],"offsetting":[193],"high-output":[194],"NO":[195,234,251,332],"production":[196,252],"iNOS.":[198],"effect":[200],"specific":[202,259],"cGMP-dependent":[204],"since":[206,224],"cAMP":[208],"pathway":[209],"unaltered.":[211],"likely":[217],"involve":[219],"reversible":[221],"biochemical":[222],"change,":[223],"responsiveness":[226],"restored":[228],"immediately":[229],"removal":[231],"excess":[233],"(by":[235,239],"1400W)":[236],"cGMP":[238],"ODQ).":[240],"observations":[242],"suggest":[243],"inflammatory":[245],"cardiovascular":[246],"disorders":[247],"associated":[248],"excessive":[250],"(i.e.":[253],"septic":[254],"shock)":[255],"characterised":[257],"impairment":[260],"GC-cGMP-mediated":[262],"vasorelaxation":[263],"mediated,":[266],"at":[267],"least":[268],"part":[270],"cGMP,":[272],"readily":[274],"reversible.":[275],"mechanism(s)":[279],"iNOS-derived":[281,331],"NO-mediated":[282,328],"pGC,":[287,374],"pharmacological":[288],"inhibition":[289,336],"phosphodiesterases":[291],"(type":[292],"5":[293],"(sildenafil),":[294],"1A1":[295],"(vinpocetine),":[296],"3":[298],"(milrinone)),":[299],"protein":[300,348],"phosphatase":[301],"2A":[302],"(okadaic":[303],"cantharidic":[306],"acid),":[307],"anion":[309],"(SOD)":[310],"myeloperoxidase":[312],"(4-aminobenzoic":[313],"hydrazide)":[314],"used":[316],"probe":[318],"role":[320],"enzymes.":[323],"Desensitisation":[324],"ANP-":[326],"dilatation":[329],"unaffected":[334],"enzymes":[339],"P>0.05":[341],"However,":[345],"activation":[346,367],"kinase":[349],"C":[350],"phorbol":[352],"12-myristate":[353],"13-acetate":[354],"thymeleatoxin":[356],"caused":[357],"both":[360],"adenylate":[363],"cyclases.":[364],"If":[365],"PKC":[366],"causes":[368],"LPS-induced":[369],"then":[375],"other":[376],"mechanisms":[377],"must":[378],"cAMP-mediated":[380],"relaxation.":[381]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
