{"id":"https://openalex.org/W2463094445","doi":null,"title":"Potentiation of antimalarial activity of arteether in combination with Vetiver root extract.","display_name":"Potentiation of antimalarial activity of arteether in combination with Vetiver root extract.","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2463094445","mag":"2463094445","pmid":"https://pubmed.ncbi.nlm.nih.gov/27319050"},"language":"en","primary_location":{"id":"pmid:27319050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27319050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sangeeta Dhawan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sangeeta Dhawan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039260103","display_name":"Sarika Gunjan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarika Gunjan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004256755","display_name":"Anirban Pal","orcid":"https://orcid.org/0000-0003-2688-7714","observed_orcids":["https://orcid.org/0000-0003-2688-7714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anirban Pal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066687301","display_name":"Renu Tripathi","orcid":"https://orcid.org/0000-0002-3719-8802","observed_orcids":["https://orcid.org/0000-0002-3719-8802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renu Tripathi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0696203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"54","issue":"5","first_page":"315","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11065","display_name":"Insect Pest Control Strategies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arteether","display_name":"arteether","score":0.9890000224113464},{"id":"https://openalex.org/keywords/antimalarial-combination-therapy","display_name":"combination antimalarial therapy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9459999799728394},{"id":"https://openalex.org/keywords/chloroquine-resistance","display_name":"chloroquine resistance","score":0.8190000057220459},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8240000009536743},{"id":"https://openalex.org/keywords/plasmodium-yoelii-nigeriensis","display_name":"Plasmodium yoelii nigeriensis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/artemisinin-resistance","display_name":"artemisinin resistance","score":0.8130000233650208},{"id":"https://openalex.org/keywords/root-extract","display_name":"root extract","score":0.5619999766349792},{"id":"https://openalex.org/keywords/fractional-inhibitory-concentration","display_name":"fractional inhibitory concentration","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.8147915005683899},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6763752698898315},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.6488271355628967},{"id":"https://openalex.org/C2776486806","wikidata":"https://www.wikidata.org/wiki/Q12065970","display_name":"Plasmodium yoelii","level":5,"score":0.6360782980918884},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.6012314558029175},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5571905374526978},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5098277926445007},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.49988865852355957},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.47666671872138977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36705267429351807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3174944818019867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2998020052909851},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2676204741001129},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.14881229400634766},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12741774320602417},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.10721498727798462},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09834808111190796}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010967","descriptor_name":"Plasmodium yoelii","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010967","descriptor_name":"Plasmodium yoelii","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049930","descriptor_name":"Chrysopogon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:27319050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27319050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},{"id":"mag:2463094445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27319050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3091902364","https://openalex.org/W3012861327","https://openalex.org/W4200505116","https://openalex.org/W1995192949","https://openalex.org/W2410223094","https://openalex.org/W7155515700","https://openalex.org/W2908369316","https://openalex.org/W3106125755","https://openalex.org/W4411256734","https://openalex.org/W2474229716"],"abstract_inverted_index":{"In":[0],"malaria,":[1],"development":[2],"of":[3,31,57,84,107,111,122,127,143,175,197,205],"resistance":[4],"towards":[5],"artemisinin":[6],"derivatives":[7],"has":[8],"urged":[9],"the":[10,21,27,140,169,178,189],"need":[11],"for":[12,45,75,168],"new":[13,16],"drugs":[14],"or":[15],"drug":[17,22],"combinations":[18,93],"to":[19,53,149,182,208],"tackle":[20],"resistant":[23,81,98],"malaria.":[24],"We":[25],"studied":[26],"fresh":[28],"root":[29],"extract":[30],"Vetiver":[32],"zizanioides":[33],"(Linn.)":[34],"Nash":[35],"(VET)":[36],"with":[37,61,124,136],"a":[38],"CDRI-CIMAP":[39],"antimalarial":[40,47,55,195],"\u03b1/\u03b2":[41],"arteether":[42],"(ART)":[43],"together":[44],"their":[46],"potential.":[48],"Our":[49],"results":[50],"showed":[51,115],"additive":[52],"synergistic":[54],"activity":[56],"VET":[58,114,128,153,163],"and":[59,71,79,113,152,164,186],"ART":[60,112,123,144,165,176,198],"sum":[62],"fractional":[63],"inhibitory":[64],"concentrations":[65],"\u03a3":[66],"FICs":[67],"1.02":[68],"\u00b1":[69,73],"0.24":[70],"1.12":[72],"0.32":[74],"chloroquine":[76,80],"sensitive":[77],"(CQS)":[78],"(CQR)":[82],"strain":[83],"Plasmodium":[85],"falciparum":[86],"(William":[87],"H.":[88],"Welch),":[89],"respectively.":[90],"Further,":[91],"these":[92],"were":[94],"explored":[95],"against":[96],"multidrug":[97],"rodent":[99],"malaria":[100],"parasite":[101],"i.e.":[102],"P.":[103],"yoelii":[104],"nigeriensis.":[105],"Analysis":[106],"in":[108,177,211],"vivo":[109],"interaction":[110],"that":[116],"10":[117],"mg/kg":[118,126],"x":[119,129],"5":[120,130],"days":[121,131],"1000":[125],"cured":[132],"100%":[133],"mice":[134],"infected":[135],"MDR":[137],"parasite,":[138],"while":[139],"same":[141],"dose":[142,174],"could":[145],"produce":[146],"only":[147],"up":[148],"30%":[150],"cure":[151],"fraction":[154],"was":[155,180,199],"not":[156],"curative":[157,173],"at":[158],"all.":[159],"Synergism/additiveness,":[160],"found":[161],"between":[162],"is":[166],"reported":[167],"first":[170],"time.":[171],"The":[172],"combination":[179],"reduced":[181],"its":[183],"one":[184],"fourth,":[185],"thus":[187],"limits":[188],"side":[190],"effects,":[191],"if":[192],"any.":[193],"Although":[194],"potential":[196],"enhanced":[200],"by":[201],"VET,":[202],"action":[203],"mechanism":[204],"later":[206],"needs":[207],"be":[209],"elucidated":[210],"detail.":[212]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
