{"id":"https://openalex.org/W2463063858","doi":"https://doi.org/10.1007/s00259-002-1056-2","title":"Bilateral increase in striatal dopamine D2 receptor density in the 6-hydroxydopamine-lesioned rat: a serial in vivo investigation with small animal PET","display_name":"Bilateral increase in striatal dopamine D2 receptor density in the 6-hydroxydopamine-lesioned rat: a serial in vivo investigation with small animal PET","publication_year":2002,"publication_date":"2002-12-17","ids":{"openalex":"https://openalex.org/W2463063858","doi":"https://doi.org/10.1007/s00259-002-1056-2","mag":"2463063858","pmid":"https://pubmed.ncbi.nlm.nih.gov/12634967"},"language":"en","primary_location":{"id":"doi:10.1007/s00259-002-1056-2","doi":"https://doi.org/10.1007/s00259-002-1056-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00259-002-1056-2","pdf_url":null,"source":{"id":"https://openalex.org/S191349260","display_name":"European Journal of Nuclear Medicine and Molecular Imaging","issn_l":"1619-7070","issn":["1619-7070","1619-7089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Nuclear Medicine and Molecular Imaging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049887984","display_name":"Susanne Nikolaus","orcid":"https://orcid.org/0000-0003-4899-3243","observed_orcids":["https://orcid.org/0000-0003-4899-3243"]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Susanne Nikolaus","raw_affiliation_strings":["Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Germany. Susanne.Nikolaus@uni-duesseldorf.de","Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Germany. Susanne.Nikolaus@uni-duesseldorf.de","institution_ids":["https://openalex.org/I4210089242"]},{"raw_affiliation_string":"Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009178279","display_name":"Rolf Larisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Larisch","raw_affiliation_strings":["Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039467443","display_name":"Markus Beu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Beu","raw_affiliation_strings":["Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023132151","display_name":"Farhad Forutan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Farhad Forutan","raw_affiliation_strings":["Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052653317","display_name":"Henning Vosberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henning Vosberg","raw_affiliation_strings":["Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111547385","display_name":"Hans\u2010Wilhelm M\u00fcller\u2010G\u00e4rtner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Wilhelm M\u00fcller-G\u00e4rtner","raw_affiliation_strings":["Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuklearmedizinische Klinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstr. 5, 40225 , D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049887984"],"corresponding_institution_ids":["https://openalex.org/I4210089242"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":null,"fwci":1.9911,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.86167314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"3","first_page":"390","last_page":"395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.17960000038146973,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6-ohda-lesion","display_name":"6-hydroxydopamine lesion","score":0.9100000262260437},{"id":"https://openalex.org/keywords/parkinson-s-disease-model","display_name":"Parkinson's disease model","score":0.7990000247955322},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.8270000219345093},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7900000214576721},{"id":"https://openalex.org/keywords/nigrostriatal-pathway","display_name":"nigrostriatal pathway","score":0.7279999852180481},{"id":"https://openalex.org/keywords/dopaminergic-denervation","display_name":"dopaminergic denervation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/compensatory-mechanisms","display_name":"compensatory mechanisms","score":0.625},{"id":"https://openalex.org/keywords/small-animal-pet","display_name":"small animal PET","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2911016594","wikidata":"https://www.wikidata.org/wiki/Q15946111","display_name":"Hydroxydopamine","level":4,"score":0.9766465425491333},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6438726782798767},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5691547393798828},{"id":"https://openalex.org/C2777288102","wikidata":"https://www.wikidata.org/wiki/Q780181","display_name":"Oxidopamine","level":5,"score":0.5191971063613892},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.5128105282783508},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.489855021238327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4709247946739197},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37174004316329956},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3453814387321472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32615137100219727},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.24571922421455383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2431710660457611},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.18579652905464172},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.048499345779418945},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001544","descriptor_name":"Benperidol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001544","descriptor_name":"Benperidol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005462","descriptor_name":"Fluorine Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00259-002-1056-2","doi":"https://doi.org/10.1007/s00259-002-1056-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00259-002-1056-2","pdf_url":null,"source":{"id":"https://openalex.org/S191349260","display_name":"European Journal of Nuclear Medicine and Molecular Imaging","issn_l":"1619-7070","issn":["1619-7070","1619-7089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Nuclear Medicine and Molecular Imaging","raw_type":"journal-article"},{"id":"pmid:12634967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12634967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of nuclear medicine and molecular imaging","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1964227543","https://openalex.org/W1979313228","https://openalex.org/W2007113119","https://openalex.org/W2014583795","https://openalex.org/W2021602283","https://openalex.org/W2024762380","https://openalex.org/W2032609908","https://openalex.org/W2043358740","https://openalex.org/W2050709677","https://openalex.org/W2054439940","https://openalex.org/W2055281234","https://openalex.org/W2056369385","https://openalex.org/W2057605474","https://openalex.org/W2071909343","https://openalex.org/W2073469785","https://openalex.org/W2076702034","https://openalex.org/W2078986708","https://openalex.org/W2087303984","https://openalex.org/W2088136957","https://openalex.org/W2121892853","https://openalex.org/W2133149013","https://openalex.org/W2136888049","https://openalex.org/W2159082363","https://openalex.org/W2163815564","https://openalex.org/W2181156226","https://openalex.org/W2185608994","https://openalex.org/W6686664470","https://openalex.org/W7025362057","https://openalex.org/W7037545765"],"related_works":["https://openalex.org/W2290520797","https://openalex.org/W2006712231","https://openalex.org/W2065987315","https://openalex.org/W2029246446","https://openalex.org/W2001882521","https://openalex.org/W2081110223","https://openalex.org/W7097499545","https://openalex.org/W7067796644","https://openalex.org/W7067437817","https://openalex.org/W2020846299"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}