{"id":"https://openalex.org/W2463019349","doi":null,"title":"[Evaluation of drug concentration in tissues after percutaneous administration of non-steroidal antirheumatics].","display_name":"[Evaluation of drug concentration in tissues after percutaneous administration of non-steroidal antirheumatics].","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2463019349","mag":"2463019349","pmid":"https://pubmed.ncbi.nlm.nih.gov/8901153"},"language":"de","primary_location":{"id":"pmid:8901153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8901153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111849477","display_name":"H. H. Wagener","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165466","display_name":"Dolorgiet (Germany)","ror":"https://ror.org/05yezgz95","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210165466"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H H Wagener","raw_affiliation_strings":["Dolorgiet Arzneimittel GmbH & Co. KG, St. Augustin/Bonn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dolorgiet Arzneimittel GmbH & Co. KG, St. Augustin/Bonn","institution_ids":["https://openalex.org/I4210165466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084848173","display_name":"Ute V\u00f6gtle-Junkert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U V\u00f6gtle-Junkert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1854,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.76275862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"3","first_page":"299","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.13130000233650208,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-drug-concentration","display_name":"tissue drug concentration","score":0.8270000219345093},{"id":"https://openalex.org/keywords/topical-nonsteroidal-anti-inflammatory-drugs","display_name":"topical nonsteroidal anti-inflammatory drugs","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":0.9929999709129333},{"id":"https://openalex.org/keywords/prostaglandin-synthesis-inhibition","display_name":"prostaglandin synthesis inhibition","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.9629999995231628},{"id":"https://openalex.org/keywords/sample-size-calculation","display_name":"sample size determination","score":0.906000018119812},{"id":"https://openalex.org/keywords/therapeutic-relevance","display_name":"therapeutic relevance","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7512694597244263},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.7043775916099548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6674802899360657},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6276164650917053},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4975936710834503}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013810","descriptor_name":"Therapeutic Equivalency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8901153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8901153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"},{"id":"mag:2463019349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8901153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W189435361","https://openalex.org/W25238561","https://openalex.org/W4236167503","https://openalex.org/W2056558699","https://openalex.org/W2100447730","https://openalex.org/W2398534444","https://openalex.org/W1973804431","https://openalex.org/W2033094138","https://openalex.org/W3039898069","https://openalex.org/W2418346905"],"abstract_inverted_index":{"For":[0],"some":[1],"10":[2],"years":[3],"it":[4,81],"has":[5],"been":[6],"usual":[7],"practice":[8],"to":[9,32],"determine":[10],"tissue":[11,52,89],"drug":[12,25],"concentrations":[13,26,53,90],"following":[14,60,75],"the":[15,23,42,45,48,88,101,106,110],"application":[16],"of":[17,44,47,63,109],"topical":[18,77],"antirheumatic":[19],"agents.":[20],"However,":[21],"testing":[22],"measured":[24],"for":[27,40],"their":[28],"therapeutic":[29,107],"relevance":[30,108],"continues":[31],"be":[33,55,93],"difficult.":[34],"An":[35],"appropriate":[36],"reference":[37],"parameter":[38],"is,":[39],"example,":[41],"IC50":[43],"inhibition":[46],"prostaglandin":[49],"synthesis.":[50],"Moreover,":[51],"should":[54],"compared":[56],"with":[57,71],"those":[58],"achieved":[59],"oral":[61,79],"administration":[62],"clinically":[64],"effective":[65],"doses.":[66],"Based":[67],"upon":[68],"practical":[69],"experience":[70],"ibuprofen":[72],"(CAS":[73],"15687-27-1)":[74],"both":[76],"and":[78,87,95,105],"administrations,":[80],"is":[82],"illustrated":[83],"how":[84],"such":[85],"studies":[86],"found":[91],"could":[92],"evaluated":[94],"interpreted":[96],"taking":[97],"into":[98],"particular":[99],"consideration":[100],"sample":[102],"size":[103],"calculation":[104],"results.":[111]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}