{"id":"https://openalex.org/W2463013442","doi":null,"title":"Efficacy and tolerability of a combined lipid-lowering nutraceutical on cholesterolemia, hs-CRP level and endothelial function in moderately hypercholesterolemic subjects.","display_name":"Efficacy and tolerability of a combined lipid-lowering nutraceutical on cholesterolemia, hs-CRP level and endothelial function in moderately hypercholesterolemic subjects.","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2463013442","mag":"2463013442","pmid":"https://pubmed.ncbi.nlm.nih.gov/27358154"},"language":"en","primary_location":{"id":"pmid:27358154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27358154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068440626","display_name":"Arrigo F.G. Cicero","orcid":"https://orcid.org/0000-0002-4367-3884","observed_orcids":["https://orcid.org/0000-0002-4367-3884"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A F Cicero","raw_affiliation_strings":["Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046258505","display_name":"Alessandro Colletti","orcid":"https://orcid.org/0000-0002-6085-2788","observed_orcids":["https://orcid.org/0000-0002-6085-2788"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Colletti","raw_affiliation_strings":["Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042277056","display_name":"Martina Rosticci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Rosticci","raw_affiliation_strings":["Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101949669","display_name":"Elisa Grandi","orcid":"https://orcid.org/0000-0003-3867-6228","observed_orcids":["https://orcid.org/0000-0003-3867-6228","https://orcid.org/0000-0001-8407-8072"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Grandi","raw_affiliation_strings":["Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055457360","display_name":"Claudio Borghi","orcid":"https://orcid.org/0000-0001-8039-8781","observed_orcids":["https://orcid.org/0000-0001-8039-8781"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Borghi","raw_affiliation_strings":["Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I9360294"],"apc_list":null,"apc_paid":null,"fwci":1.8973,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.86853717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"30","issue":"2","first_page":"593","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.26930001378059387,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8849999904632568},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9789999723434448},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9010000228881836},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.8140000104904175},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8085556030273438},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7613177299499512},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.7090671062469482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6879969239234924},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.5904353857040405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.574953019618988},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.50826495885849},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39451026916503906},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33330947160720825},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.23859214782714844},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06958359479904175},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:27358154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27358154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/565822","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/565822","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2463013442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27358154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3026407656","https://openalex.org/W3184481985","https://openalex.org/W2067142064","https://openalex.org/W2941563071","https://openalex.org/W2043826108","https://openalex.org/W2472211112","https://openalex.org/W4390583477","https://openalex.org/W2728777968","https://openalex.org/W2900826445","https://openalex.org/W2995099458"],"abstract_inverted_index":{"Our":[0],"aim":[1],"was":[2,143],"to":[3,51,83,147,166,178],"test,":[4],"by":[5],"a":[6,13,17,26,69,90],"double-blind,":[7],"placebo-controlled":[8],"randomized":[9,50],"clinical":[10],"trial,":[11],"whether":[12],"short-term":[14],"treatment":[15,68,87],"with":[16],"combined":[18],"lipid-lowering":[19,55,163],"nutraceutical":[20,56,86,164],"could":[21],"improve":[22,168],"endothelial":[23,77,125,169],"function":[24,78,126,170],"in":[25,95,145,171],"cohort":[27],"of":[28,45,67,158],"moderately":[29,35,172],"hypercholesterolemic":[30,36,173],"subjects.":[31,174],"Thus,":[32],"80":[33],"healthy,":[34],"subjects":[37],"were":[38,49,79],"consecutively":[39],"enrolled":[40],"and,":[41],"after":[42],"4":[43],"weeks":[44],"stabilization":[46],"diet,":[47],"they":[48],"either":[52],"the":[53,63,156,161],"tested":[54,162],"or":[57],"placebo":[58,137],"for":[59],"8":[60],"weeks.":[61],"At":[62],"beginning":[64],"and":[65,76,124,152,185],"end":[66],"complete":[70],"lipid":[71],"pattern,":[72],"safety":[73,153],"parameters,":[74],"hs-CRP":[75,115,120],"measured.":[80],"When":[81],"compared":[82],"placebo,":[84],"during":[85],"patients":[88],"experienced":[89],"more":[91],"favorable":[92],"percentage":[93],"change":[94],"total":[96],"cholesterol":[97],"(TC":[98],"vs":[99,103,108,112,117,121,130,136],"baseline:":[100,109,118,131],"-17.9%;":[101],"TC":[102],"placebo:":[104,113,122],"-5.6%),":[105],"LDL-cholesterol":[106],"(LDL-C":[107],"-23.3%;":[110],"LDL-C":[111],"-2.8%),":[114],"(hs-CRP":[116],"-2.4%;":[119],"-1.5%),":[123],"(pulse":[127],"volume":[128,134],"displacement":[129,135],"+17%;":[132],"pulse":[133],"treatment:":[138],"-3.3%).":[139],"No":[140],"significant":[141],"difference":[142],"observed":[144],"respect":[146],"effects":[148],"on":[149,181],"triglycerides,":[150],"HDL-cholesterol":[151],"parameters.":[154],"On":[155],"basis":[157],"our":[159],"data,":[160],"seems":[165],"significantly":[167],"These":[175],"results":[176],"have":[177],"be":[179],"confirmed":[180],"larger":[182],"patient":[183],"samples":[184],"over":[186],"longer":[187],"periods.":[188]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
