{"id":"https://openalex.org/W2462938136","doi":null,"title":"Successful xenotransplantation of microencapsulated newborn pig parathyroid cells in the treatment of hypoparathyroidism in rats.","display_name":"Successful xenotransplantation of microencapsulated newborn pig parathyroid cells in the treatment of hypoparathyroidism in rats.","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W2462938136","mag":"2462938136","pmid":"https://pubmed.ncbi.nlm.nih.gov/12935402"},"language":"en","primary_location":{"id":"pmid:12935402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12935402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014129991","display_name":"Lemin Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lemin Lin","raw_affiliation_strings":["Department of Surgery, First Hospital of Harbin Medical University, Harbin 150001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, First Hospital of Harbin Medical University, Harbin 150001, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023912850","display_name":"Yimin Song","orcid":"https://orcid.org/0000-0002-9731-2865","observed_orcids":["https://orcid.org/0000-0002-9731-2865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yimin Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110186670","display_name":"Chun Song","orcid":"https://orcid.org/0000-0003-2261-6263","observed_orcids":["https://orcid.org/0000-0003-2261-6263"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101480265","display_name":"Ping Xu","orcid":"https://orcid.org/0009-0001-9927-134X","observed_orcids":["https://orcid.org/0009-0001-9927-134X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101041049","display_name":"Song Chunfang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunfang Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6391,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75456821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"116","issue":"8","first_page":"1161","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/parathyroid-cells","display_name":"parathyroid cells","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hypoparathyroidism","display_name":"hypoparathyroidism","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cell-microencapsulation","display_name":"cell microencapsulation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/serum-calcium","display_name":"serum calcium","score":0.6050000190734863},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.45899999141693115},{"id":"https://openalex.org/keywords/immunosuppression-free-transplantation","display_name":"immunosuppression-free transplantation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2778442404","wikidata":"https://www.wikidata.org/wiki/Q55505","display_name":"Xenotransplantation","level":3,"score":0.8457306623458862},{"id":"https://openalex.org/C193699699","wikidata":"https://www.wikidata.org/wiki/Q3272785","display_name":"Parathyroid chief cell","level":4,"score":0.8068322539329529},{"id":"https://openalex.org/C2775941721","wikidata":"https://www.wikidata.org/wiki/Q1586088","display_name":"Hypoparathyroidism","level":2,"score":0.7786208391189575},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6975489258766174},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.595659077167511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4497497081756592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43321794271469116},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42094871401786804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3834494352340698},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.33043745160102844},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3270528316497803}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010280","descriptor_name":"Parathyroid Glands","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010280","descriptor_name":"Parathyroid Glands","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12935402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12935402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:2462938136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12935402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2364098423","https://openalex.org/W2373695059","https://openalex.org/W2426681787","https://openalex.org/W2378411987","https://openalex.org/W2086754439","https://openalex.org/W2941528831","https://openalex.org/W2023088425","https://openalex.org/W2377934655","https://openalex.org/W4361191080","https://openalex.org/W1995307854"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2,206],"the":[3,19,93,116,124,128,141,158,173,177,208],"effect":[4,156],"of":[5,21,186,204,212],"xenotransplantation":[6],"with":[7,63,111],"pig":[8,189],"parathyroid":[9,66,70,82,114,174,190,215],"cells,":[10,67,71,115],"which":[11],"was":[12,60],"prepared":[13],"using":[14,199],"cell":[15],"microencapsulation":[16],"technique,":[17],"on":[18,157],"treatment":[20],"hypoparathyroidism":[22,195],"in":[23,39,138,140,182,196],"rats":[24,46,139,197],"without":[25,198],"immunosuppressor.":[26],"METHODS:":[27],"Parathyroid":[28],"cells":[29,175,191],"were":[30,47,85,96,121,136,151],"isolated":[31],"from":[32],"10":[33],"healthy":[34],"newborn":[35,188],"pigs":[36],"and":[37,55,81,98,102,118],"encapsulated":[38,64],"alginate-polylysine-alginate":[40],"(APA)":[41],"membranes.":[42],"Thirty-two":[43],"aparathyroid":[44],"Wistar":[45],"randomly":[48],"allocated":[49],"to":[50,100,153],"microcapsule,":[51,54],"non-microcapsule,":[52],"empty":[53,72,146],"control":[56],"groups.":[57],"Each":[58],"rat":[59],"injected":[61],"intraperitoneally":[62],"porcine":[65,69,113,214],"free":[68],"capsules":[73,147],"or":[74,162],"0.9%":[75,149],"NaCl,":[76],"respectively.":[77],"Total":[78],"serum":[79,160],"calcium":[80,117,161],"hormone":[83],"levels":[84,120],"monitored":[86],"continuously":[87],"for":[88],"40":[89,129,166],"weeks.":[90,130],"And":[91],"then,":[92],"transplant":[94],"beds":[95],"retrieved":[97],"subjected":[99],"morphologic":[101],"electron":[103,168],"microscopic":[104,169],"examination.":[105],"RESULTS:":[106],"In":[107,131],"those":[108],"animals":[109],"xenotransplanted":[110],"microencapsulated":[112,187,213],"PTH":[119,163],"consistently":[122],"within":[123,176],"normal":[125],"range":[126],"during":[127],"contrast,":[132],"no":[133],"therapeutic":[134],"effects":[135],"observed":[137],"non-microcapsule":[142],"group.":[143],"Furthermore,":[144],"neither":[145],"nor":[148],"NaCl":[150],"shown":[152],"have":[154],"any":[155],"recipient's":[159],"levels.":[164],"After":[165],"weeks,":[167],"examination":[170],"demonstrated":[171],"that":[172],"microcapsules":[178],"had":[179],"survived":[180],"well":[181],"vivo.":[183],"CONCLUSIONS:":[184],"Xenotransplantation":[185],"can":[192],"successfully":[193],"treat":[194],"immunosuppressive":[200],"drugs.":[201],"The":[202],"results":[203],"this":[205],"show":[207],"possible":[209],"clinical":[210],"use":[211],"cells.":[216]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}