{"id":"https://openalex.org/W2462895704","doi":null,"title":"The effect of thymic function on immunocompetence following bone marrow transplantation.","display_name":"The effect of thymic function on immunocompetence following bone marrow transplantation.","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W2462895704","mag":"2462895704","pmid":"https://pubmed.ncbi.nlm.nih.gov/9118285"},"language":"en","primary_location":{"id":"pmid:9118285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9118285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046180673","display_name":"Kenneth I. Weinberg","orcid":"https://orcid.org/0000-0003-1922-9131","observed_orcids":["https://orcid.org/0000-0003-1922-9131"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Weinberg","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Children's Hospital Los Angeles, CA 90027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Children's Hospital Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108102861","display_name":"Geralyn Annett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Annett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089688977","display_name":"A. Kashyap","orcid":"https://orcid.org/0009-0002-3487-0736","observed_orcids":["https://orcid.org/0009-0002-3487-0736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Kashyap","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039098373","display_name":"Carl Lenarsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Lenarsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039374832","display_name":"Stephen J. Forman","orcid":"https://orcid.org/0000-0002-2803-4152","observed_orcids":["https://orcid.org/0000-0002-2803-4152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J Forman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045306382","display_name":"Robertson Parkman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Parkman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7548,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.90905354,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"18","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.08070000261068344,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymic-function","display_name":"thymic function","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/immunocompetence","display_name":"immunocompetence","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cd45ra","display_name":"CD45RA","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cd45ro","display_name":"CD45RO","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/thymic-aging","display_name":"thymic aging","score":0.9290000200271606},{"id":"https://openalex.org/keywords/chronic-graft-versus-host-disease","display_name":"chronic graft-versus-host disease","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tetanus-toxoid","display_name":"tetanus toxoid","score":0.8130000233650208},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.6639999747276306},{"id":"https://openalex.org/keywords/recipient-age","display_name":"recipient age","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2777422395","wikidata":"https://www.wikidata.org/wiki/Q3149136","display_name":"Immunocompetence","level":3,"score":0.7119480967521667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7058921456336975},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6592783331871033},{"id":"https://openalex.org/C2777351567","wikidata":"https://www.wikidata.org/wiki/Q908822","display_name":"Toxoid","level":4,"score":0.6290166974067688},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6204125285148621},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.530487596988678},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.49724939465522766},{"id":"https://openalex.org/C2779841045","wikidata":"https://www.wikidata.org/wiki/Q47790","display_name":"Tetanus","level":3,"score":0.48436054587364197},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.46698349714279175},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.46156635880470276},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4457295536994934},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21865618228912354},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.12896868586540222},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.11825481057167053}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9118285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9118285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation","raw_type":"Journal Article"},{"id":"mag:2462895704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9118285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G6385617418","display_name":"Hematopoietic Cell Transplantation for Hematologic Malignancies","funder_award_id":"P01CA030206","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2054405406","https://openalex.org/W2014779265","https://openalex.org/W2521848976","https://openalex.org/W50679872","https://openalex.org/W2036858642","https://openalex.org/W2552432659","https://openalex.org/W1683467081","https://openalex.org/W2092537922","https://openalex.org/W989783833","https://openalex.org/W1977066411"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,8,37,79,94,100,142,163,176,201,213,241],"role":[3],"of":[4,19,40,71,96,102,154,165,203,215,240],"thymic":[5,86,243],"function":[6,87,123,172,190,232],"in":[7,91,109,128,162,187],"immunodeficiency":[9],"that":[10,198,233],"characterizes":[11],"bone":[12],"marrow":[13],"transplantation":[14],"(BMT)":[15],"recipients.":[16],"The":[17],"capacity":[18],"histocompatible":[20],"BMT":[21,110,145],"recipients":[22,111,146,179,224],"to":[23,36,132,152,237],"generate":[24],"new":[25,103,204],"CD4+":[26],"T":[27,50,61,74,105,167,206,218],"lymphocytes":[28,106,207,219],"was":[29,107,124,158,173],"determined":[30,108,125],"by":[31,126,247],"FACS":[32],"analysis":[33],"with":[34,89,112,180,200,225],"antibodies":[35],"two":[38],"isoforms":[39],"CD45:":[41],"CD45RA,":[42],"which":[43,54,76],"is":[44,55],"expressed":[45,56],"on":[46,57,99],"newly":[47],"generated":[48],"CD4":[49,60,73],"lymphocytes,":[51,75,168],"and":[52,82,113,169,194,249],"CD45RO,":[53],"antigen-specific":[58,121,170,230],"memory":[59,216],"lymphocytes.":[62],"Immediately":[63],"following":[64],"BMT,":[65],"all":[66],"patients":[67],"had":[68,183],"low":[69],"levels":[70],"CD45RA-expressing":[72],"increased":[77],"during":[78],"first":[80],"year":[81,139],"then":[83],"stabilized.":[84],"Since":[85],"decreases":[88],"age":[90,98],"normal":[92,155,242],"individuals,":[93],"impact":[95],"recipient":[97],"generation":[101],"CD45RA,CD4":[104,166,205],"without":[114,147],"chronic":[115,148,181,226],"graft-vs.-host":[116],"disease":[117],"(GVHD).":[118],"In":[119],"addition,":[120],"immune":[122,171,189,231],"assessing":[127],"vitro":[129],"blastogenic":[130],"response":[131],"tetanus":[133],"toxoid":[134],"(TT).":[135],"More":[136],"than":[137],"1":[138],"after":[140],"transplantation,":[141],"results":[143],"from":[144],"GVHD":[149,182,227,248],"were":[150],"similar":[151],"those":[153],"individuals;":[156],"there":[157],"an":[159,184,238],"age-dependent":[160,185],"decline":[161,186],"number":[164,202,214],"age-independent.":[174],"On":[175],"other":[177],"hand,":[178],"their":[188],"(r":[191],"=":[192,196,209,221],"0.45":[193],"p":[195],"0.02)":[197],"correlated":[199],"(p":[208,220],"0.027)":[210],"but":[211],"not":[212],"CD45RO,CD4":[217],"0.11).":[222],"Thus":[223],"have":[228],"decreased":[229],"may":[234],"be":[235],"due":[236],"acceleration":[239],"aging":[244],"process":[245],"induced":[246],"its":[250],"therapy.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
