{"id":"https://openalex.org/W2462572012","doi":"https://doi.org/10.1097/hp.0000000000000339","title":"An Interlaboratory Validation of the Radiation Dose Response Relationship (DRR) for H-ARS in the Rhesus Macaque","display_name":"An Interlaboratory Validation of the Radiation Dose Response Relationship (DRR) for H-ARS in the Rhesus Macaque","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W2462572012","doi":"https://doi.org/10.1097/hp.0000000000000339","mag":"2462572012","pmid":"https://pubmed.ncbi.nlm.nih.gov/26425909"},"language":"en","primary_location":{"id":"doi:10.1097/hp.0000000000000339","doi":"https://doi.org/10.1097/hp.0000000000000339","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hp.0000000000000339","pdf_url":null,"source":{"id":"https://openalex.org/S100299040","display_name":"Health Physics","issn_l":"0017-9078","issn":["0017-9078","1538-5159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086887484","display_name":"Karla D. Thrall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210122479","display_name":"Shin Nippon Biomedical Laboratories (United States)","ror":"https://ror.org/0270p7k56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122479"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karla D. Thrall","raw_affiliation_strings":["*SNBL USA Ltd, 6605 Merrill Creek Parkway, Everett, WA; \u2020Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD","SNBL USA Ltd, 6605 Merrill Creek Parkway, Everett, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*SNBL USA Ltd, 6605 Merrill Creek Parkway, Everett, WA; \u2020Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"SNBL USA Ltd, 6605 Merrill Creek Parkway, Everett, WA","institution_ids":["https://openalex.org/I4210122479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110223837","display_name":"Ruschelle Love","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122479","display_name":"Shin Nippon Biomedical Laboratories (United States)","ror":"https://ror.org/0270p7k56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122479"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ruschelle Love","raw_affiliation_strings":["SNBL USA Ltd, 6605 Merrill Creek Parkway, Everett, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SNBL USA Ltd, 6605 Merrill Creek Parkway, Everett, WA","institution_ids":["https://openalex.org/I4210122479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075450004","display_name":"Kyle C. O'Donnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle C. O'Donnell","raw_affiliation_strings":["Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065146089","display_name":"Ann M. Farese","orcid":"https://orcid.org/0000-0003-2318-5135","observed_orcids":["https://orcid.org/0000-0003-2318-5135"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann M. Farese","raw_affiliation_strings":["Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111786597","display_name":"Ronald G. Manning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122479","display_name":"Shin Nippon Biomedical Laboratories (United States)","ror":"https://ror.org/0270p7k56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122479"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald Manning","raw_affiliation_strings":["SNBL USA Ltd, 6605 Merrill Creek Parkway, Everett, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SNBL USA Ltd, 6605 Merrill Creek Parkway, Everett, WA","institution_ids":["https://openalex.org/I4210122479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085873334","display_name":"Thomas J. MacVittie","orcid":"https://orcid.org/0000-0003-0851-6290","observed_orcids":["https://orcid.org/0000-0003-0851-6290"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. MacVittie","raw_affiliation_strings":["Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086887484","https://openalex.org/A5110223837","https://openalex.org/A5111786597"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4210122479"],"apc_list":null,"apc_paid":null,"fwci":2.6973,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.89371219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"109","issue":"5","first_page":"502","last_page":"510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-acute-radiation-syndrome","display_name":"hematopoietic acute radiation syndrome","score":0.9810000061988831},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.9459999799728394},{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/medical-countermeasures","display_name":"medical countermeasures","score":0.6959999799728394},{"id":"https://openalex.org/keywords/animal-model-validation","display_name":"animal model validation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/interlaboratory-validation","display_name":"interlaboratory validation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.527999997138977},{"id":"https://openalex.org/keywords/lethality","display_name":"lethality","score":0.6050000190734863},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.5080000162124634},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/supportive-care","display_name":"supportive care","score":0.5130000114440918},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.7760000228881836},{"id":"https://openalex.org/keywords/animal-rule","display_name":"Animal Rule","score":0.5870000123977661},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2908890008","wikidata":"https://www.wikidata.org/wiki/Q275459","display_name":"Acute Radiation Syndrome","level":4,"score":0.8079174757003784},{"id":"https://openalex.org/C2779175743","wikidata":"https://www.wikidata.org/wiki/Q156606","display_name":"Rhesus macaque","level":2,"score":0.6621227860450745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6550701260566711},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5928194522857666},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5707388520240784},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5263556241989136},{"id":"https://openalex.org/C190892606","wikidata":"https://www.wikidata.org/wiki/Q3512464","display_name":"Radiological weapon","level":2,"score":0.4788203835487366},{"id":"https://openalex.org/C3017588741","wikidata":"https://www.wikidata.org/wiki/Q3042357","display_name":"Dose rate","level":2,"score":0.47773975133895874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2583691477775574},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.22656315565109253},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2099631428718567},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.1617644727230072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1258719563484192},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11664837598800659},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.11312881112098694},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007753","descriptor_name":"Laboratories","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054508","descriptor_name":"Acute Radiation Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D054508","descriptor_name":"Acute Radiation Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D054508","descriptor_name":"Acute Radiation Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/hp.0000000000000339","doi":"https://doi.org/10.1097/hp.0000000000000339","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hp.0000000000000339","pdf_url":null,"source":{"id":"https://openalex.org/S100299040","display_name":"Health Physics","issn_l":"0017-9078","issn":["0017-9078","1538-5159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Physics","raw_type":"journal-article"},{"id":"pmid:26425909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26425909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health physics","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2199075077","https://openalex.org/W2280348146"],"related_works":["https://openalex.org/W2410853304","https://openalex.org/W4306697311","https://openalex.org/W2044229897","https://openalex.org/W4307187904","https://openalex.org/W3200184017","https://openalex.org/W2024719775","https://openalex.org/W3087277436","https://openalex.org/W4408684870","https://openalex.org/W4413623079","https://openalex.org/W3107095887"],"abstract_inverted_index":{"The":[0,62,183,241],"Medical":[1],"Countermeasures":[2],"against":[3],"Radiological":[4],"Threats":[5],"(MCART)":[6],"consortium":[7,77],"has":[8],"established":[9,247],"a":[10,41,93,102,146,262],"dose":[11,89,147,237],"response":[12,90],"relationship":[13,91],"for":[14,43,105,239,274],"the":[15,22,54,76,82,98,108,118,121,125,161,224,235,245,265,268,272],"hematopoietic":[16],"acute":[17],"radiation":[18,88],"syndrome":[19],"(HARS)":[20],"in":[21,78,92,117,276],"rhesus":[23,130],"macaque":[24],"conducted":[25],"under":[26],"an":[27,73,86,112],"individualized":[28],"supportive":[29],"care":[30],"protocol,":[31],"including":[32,164],"blood":[33],"transfusions.":[34],"Application":[35],"of":[36,46,68,97,107,120,149,160,213,258,267],"this":[37],"animal":[38,99],"model":[39,55,100,109,253,269],"as":[40,111],"platform":[42],"demonstrating":[44],"efficacy":[45],"candidate":[47],"medical":[48],"countermeasures":[49],"is":[50,56,101,261],"significantly":[51],"strengthened":[52],"when":[53],"independently":[57],"validated":[58],"at":[59,72,145,186],"multiple":[60],"institutions.":[61],"study":[63],"reported":[64,181],"here":[65],"describes":[66],"implementation":[67,257],"standard":[69],"operating":[70],"procedures":[71,260],"institute":[74],"outside":[75],"order":[79],"to":[80,84,136,174,193,209,243,264],"evaluate":[81],"ability":[83,242],"establish":[85],"equivalent":[87,208],"selected":[94],"species.":[95],"Validation":[96],"significant":[103],"component":[104],"consideration":[106],"protocol":[110],"FDA-recommended":[113],"drug":[114],"development":[115],"tool":[116],"context":[119],"\"Animal":[122],"Rule.\"":[123],"In":[124],"current":[126],"study,":[127],"48":[128],"male":[129],"macaques":[131],"(4-8":[132],"kg)":[133],"were":[134,191],"exposed":[135],"total-body":[137],"irradiation":[138],"(TBI)":[139],"using":[140],"6":[141],"MV":[142],"photon":[143],"energy":[144],"rate":[148],"approximately":[150],"0.8":[151],"Gy":[152,176,196,199,203,215,218,222],"min.":[153],"Results":[154],"show":[155,232],"that":[156],"onset":[157],"and":[158,167,201,220,230,252,270],"duration":[159],"hematological":[162],"response,":[163],"anemia,":[165],"neutropenia,":[166],"thrombocytopenia,":[168],"following":[169,189],"TBI":[170,190],"ranging":[171],"from":[172],"6.25":[173],"8.75":[175],"correlate":[177],"well":[178],"with":[179],"previously":[180,212,246],"findings.":[182],"lethality":[184,249],"values":[185,206],"60":[187],"d":[188],"estimated":[192],"be":[194],"6.88":[195],"(LD30/60),":[197,216],"7.43":[198],"(LD50/60),":[200,219],"7.98":[202],"(LD70/60).":[204],"These":[205],"are":[207],"those":[210],"published":[211],"7.06":[214],"7.52":[217],"7.99":[221],"(LD70/60);":[223],"DRR":[225],"slope":[226],"(p":[227],"=":[228],"0.68)":[229],"y-intercepts":[231],"agreement":[233],"along":[234],"complete":[236],"range":[238],"HARS.":[240],"replicate":[244],"institutional":[248],"profile":[250],"(PROBIT)":[251],"outcomes":[254],"through":[255],"careful":[256],"defined":[259],"testament":[263],"robustness":[266],"highlights":[271],"need":[273],"consistency":[275],"procedures.":[277]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}