{"id":"https://openalex.org/W2462428686","doi":null,"title":"Impact of CYP2C19 genetics on pharmacokinetic variability of escitalopram and sertraline : a study based on therapeutic drug monitoring data","display_name":"Impact of CYP2C19 genetics on pharmacokinetic variability of escitalopram and sertraline : a study based on therapeutic drug monitoring data","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2462428686","mag":"2462428686"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/11881","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/11881","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/11881","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038586857","display_name":"Ida Rudberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ida Rudberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038586857"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2c19","display_name":"CYP2C19","score":0.8859999775886536},{"id":"https://openalex.org/keywords/escitalopram","display_name":"escitalopram","score":0.9470000267028809},{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":0.949999988079071},{"id":"https://openalex.org/keywords/pharmacokinetic-variability","display_name":"pharmacokinetic variability","score":0.9909999966621399},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8420000076293945},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.8489999771118164},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.6129999756813049},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.46000000834465027},{"id":"https://openalex.org/keywords/poor-metabolizers","display_name":"poor metabolizers","score":0.7649999856948853},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.6079999804496765},{"id":"https://openalex.org/keywords/psychiatric-patients","display_name":"psychiatric patients","score":0.4309999942779541},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4090000092983246},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.625},{"id":"https://openalex.org/keywords/cyp2c19-genotyping","display_name":"CYP2C19 genotyping","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.6069999933242798},{"id":"https://openalex.org/keywords/norway","display_name":"Norway","score":0.3089999854564667},{"id":"https://openalex.org/keywords/cyp2c19-2","display_name":"CYP2C19*2","score":0.39899998903274536},{"id":"https://openalex.org/keywords/cyp2c19-3","display_name":"CYP2C19*3","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C140840227","wikidata":"https://www.wikidata.org/wiki/Q3737532","display_name":"CYP2C19","level":4,"score":0.9689711332321167},{"id":"https://openalex.org/C2779583969","wikidata":"https://www.wikidata.org/wiki/Q423757","display_name":"Escitalopram","level":4,"score":0.9598543643951416},{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.8145517706871033},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8029489517211914},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6925426721572876},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.6291537880897522},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.5464015603065491},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.4500751793384552},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.42262354493141174},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39107638597488403},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.35638147592544556},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.3078833222389221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30375155806541443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27549487352371216},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16357183456420898},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1540667712688446},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.11980417370796204},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10487338900566101},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/11881","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/11881","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2462428686","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/bitstream/10852/11881/3/Rudberg-avhandling-publ.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/11881","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/11881","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":177,"referenced_works":["https://openalex.org/W75129300","https://openalex.org/W169157119","https://openalex.org/W196795570","https://openalex.org/W1480339013","https://openalex.org/W1550666015","https://openalex.org/W1679888853","https://openalex.org/W1781676997","https://openalex.org/W1797511347","https://openalex.org/W1894417684","https://openalex.org/W1898846685","https://openalex.org/W1915630750","https://openalex.org/W1964149730","https://openalex.org/W1965270391","https://openalex.org/W1966245701","https://openalex.org/W1966841478","https://openalex.org/W1967299205","https://openalex.org/W1967502648","https://openalex.org/W1969143567","https://openalex.org/W1969933572","https://openalex.org/W1970635809","https://openalex.org/W1972536047","https://openalex.org/W1972775745","https://openalex.org/W1972837206","https://openalex.org/W1974604392","https://openalex.org/W1974969497","https://openalex.org/W1978742008","https://openalex.org/W1979061109","https://openalex.org/W1979157261","https://openalex.org/W1979157320","https://openalex.org/W1979293025","https://openalex.org/W1980050671","https://openalex.org/W1981413819","https://openalex.org/W1981612922","https://openalex.org/W1982290436","https://openalex.org/W1982377331","https://openalex.org/W1982886582","https://openalex.org/W1984131408","https://openalex.org/W1984574841","https://openalex.org/W1985059672","https://openalex.org/W1986064902","https://openalex.org/W1986277865","https://openalex.org/W1987337079","https://openalex.org/W1987375927","https://openalex.org/W1988612597","https://openalex.org/W1988853236","https://openalex.org/W1990259537","https://openalex.org/W1990904235","https://openalex.org/W1991163272","https://openalex.org/W1991796054","https://openalex.org/W1993067969","https://openalex.org/W1994428956","https://openalex.org/W1997656392","https://openalex.org/W1999607153","https://openalex.org/W2000357710","https://openalex.org/W2000789841","https://openalex.org/W2001275508","https://openalex.org/W2001657113","https://openalex.org/W2002467319","https://openalex.org/W2003410018","https://openalex.org/W2005534453","https://openalex.org/W2007781929","https://openalex.org/W2008486886","https://openalex.org/W2009386434","https://openalex.org/W2009966911","https://openalex.org/W2012407966","https://openalex.org/W2013030667","https://openalex.org/W2013832113","https://openalex.org/W2014163105","https://openalex.org/W2015383341","https://openalex.org/W2016382954","https://openalex.org/W2016911934","https://openalex.org/W2018008180","https://openalex.org/W2021986001","https://openalex.org/W2023445503","https://openalex.org/W2024615735","https://openalex.org/W2025416272","https://openalex.org/W2026266772","https://openalex.org/W2028194357","https://openalex.org/W2028716308","https://openalex.org/W2029995473","https://openalex.org/W2031906146","https://openalex.org/W2037828590","https://openalex.org/W2040679011","https://openalex.org/W2043153381","https://openalex.org/W2045530950","https://openalex.org/W2049377642","https://openalex.org/W2050998203","https://openalex.org/W2051221453","https://openalex.org/W2052098936","https://openalex.org/W2057710656","https://openalex.org/W2057794326","https://openalex.org/W2060180669","https://openalex.org/W2061800286","https://openalex.org/W2062098873","https://openalex.org/W2062815987","https://openalex.org/W2063237368","https://openalex.org/W2063905878","https://openalex.org/W2066269357","https://openalex.org/W2067837334","https://openalex.org/W2068398215","https://openalex.org/W2069131192","https://openalex.org/W2070055730","https://openalex.org/W2070847795","https://openalex.org/W2071728786","https://openalex.org/W2072219714","https://openalex.org/W2072408576","https://openalex.org/W2073557728","https://openalex.org/W2074460311","https://openalex.org/W2075702840","https://openalex.org/W2075848615","https://openalex.org/W2081558811","https://openalex.org/W2082363592","https://openalex.org/W2083286337","https://openalex.org/W2083532517","https://openalex.org/W2083597120","https://openalex.org/W2083976782","https://openalex.org/W2084686194","https://openalex.org/W2086439537","https://openalex.org/W2086958703","https://openalex.org/W2087140917","https://openalex.org/W2089053670","https://openalex.org/W2090167086","https://openalex.org/W2092191147","https://openalex.org/W2092629624","https://openalex.org/W2097627764","https://openalex.org/W2098371153","https://openalex.org/W2098867544","https://openalex.org/W2106443841","https://openalex.org/W2108765637","https://openalex.org/W2110919375","https://openalex.org/W2112110234","https://openalex.org/W2112403775","https://openalex.org/W2114164865","https://openalex.org/W2114903378","https://openalex.org/W2116733205","https://openalex.org/W2121074897","https://openalex.org/W2121858592","https://openalex.org/W2126226320","https://openalex.org/W2131053945","https://openalex.org/W2131131247","https://openalex.org/W2131662866","https://openalex.org/W2132135389","https://openalex.org/W2134334380","https://openalex.org/W2135122521","https://openalex.org/W2142514218","https://openalex.org/W2144312659","https://openalex.org/W2145542533","https://openalex.org/W2149154629","https://openalex.org/W2150274550","https://openalex.org/W2151660707","https://openalex.org/W2152548272","https://openalex.org/W2154579091","https://openalex.org/W2158392145","https://openalex.org/W2159435181","https://openalex.org/W2159858918","https://openalex.org/W2159940312","https://openalex.org/W2160716066","https://openalex.org/W2162787841","https://openalex.org/W2163246271","https://openalex.org/W2163461690","https://openalex.org/W2166149118","https://openalex.org/W2167407582","https://openalex.org/W2167977201","https://openalex.org/W2168536639","https://openalex.org/W2170125927","https://openalex.org/W2170495663","https://openalex.org/W2170524922","https://openalex.org/W2193494830","https://openalex.org/W2221478595","https://openalex.org/W2288991238","https://openalex.org/W2313921179","https://openalex.org/W2328274691","https://openalex.org/W2333119515","https://openalex.org/W2337971231","https://openalex.org/W2370977081","https://openalex.org/W2405023425","https://openalex.org/W2952997412"],"related_works":["https://openalex.org/W1994337442","https://openalex.org/W2372087023","https://openalex.org/W3039011210","https://openalex.org/W2802325674","https://openalex.org/W4410260926","https://openalex.org/W2981877456","https://openalex.org/W2159834407","https://openalex.org/W4400026406","https://openalex.org/W3207916592","https://openalex.org/W2072408576"],"abstract_inverted_index":{"Escitalopram":[0],"and":[1,53,75,116,233,242,304,311],"sertraline":[2,76,207,214,243],"are":[3,247,277,289],"among":[4],"the":[5,11,28,49,64,70,98,127,156,168,191,204,252,293,299,313,316],"most":[6,183],"widely":[7],"used":[8],"drugs":[9,18],"in":[10,15,40,48,77,174,197,220,238,298,329],"treatment":[12,256,308],"of":[13,51,57,66,73,82,97,100,107,160,167,177,203,206,213,240,248,266,271,282,295,301,315,331],"depression":[14],"Norway.":[16],"Both":[17],"show":[19],"substantial":[20,236],"pharmacokinetic":[21,71],"variability.":[22],"Previous":[23],"studies":[24,288],"have":[25],"indicated":[26],"that":[27,152],"drug":[29,86],"metabolising":[30],"enzyme":[31],"cytochrome":[32],"P450":[33],"2C19":[34],"(CYP2C19),":[35],"which":[36],"exhibits":[37],"extensive":[38,124],"variability":[39,72,196,328],"activity":[41],"due":[42],"to":[43,62,92,122,164,224,291,326],"genetic":[44],"polymorphism,":[45],"is":[46],"involved":[47],"metabolism":[50],"escitalopram":[52,74,108,178,241,310],"sertraline.":[54],"The":[55,172,235],"aim":[56],"this":[58],"thesis":[59,318],"was":[60,90,129,149,162,199,215],"therefore":[61],"investigate":[63,292],"impact":[65],"CYP2C19":[67,88,112,117,123,133,180,198,221,231,245,260,275,296],"genetics":[68],"on":[69,190,216],"psychiatric":[78],"patients.":[79],"By":[80],"use":[81],"data":[83],"from":[84],"therapeutic":[85,272,302],"monitoring,":[87],"genotype":[89],"shown":[91],"be":[93],"a":[94,187,264,321],"major":[95],"determinant":[96,202],"pharmacokinetics":[99,205,239],"escitalopram.":[101],"On":[102],"average,":[103],"dose-adjusted":[104,144],"serum":[105,145,175,211],"concentration":[106,176,212],"differed":[109],"9.7-fold":[110],"between":[111,179,230,244],"poor":[113],"metabolisers":[114,119,125],"(PMs)":[115],"ultrarapid":[118],"(UMs).":[120],"Compared":[121],"(EMs),":[126],"effect":[128,189],"more":[130],"pronounced":[131],"for":[132,136,251,323],"PMs":[134,222,276],"than":[135],"UMs":[137,232,261],"(5.7-fold":[138],"higher":[139,219,280],"vs.":[140],"42%":[141],"lower":[142],"mean":[143],"concentration,":[146],"respectively).":[147],"It":[148],"further":[150,287],"identified":[151],"CYP2C19,":[153],"besides":[154],"catalysing":[155],"well":[157],"known":[158],"N-desmethylation":[159],"escitalopram,":[161],"able":[163],"catalyse":[165],"formation":[166],"propionic":[169],"acid":[170],"metabolite.":[171],"differences":[173,237],"genotypes":[181,246],"were":[182],"likely":[184],"caused":[185],"by":[186],"combined":[188],"two":[192],"metabolic":[193],"pathways.":[194],"Genetic":[195],"an":[200],"important":[201],"as":[208],"well.":[209],"Dose-adjusted":[210],"average":[217],"3.2-fold":[218],"compared":[223],"EMs,":[225],"but":[226],"did":[227],"not":[228],"differ":[229],"EMs.":[234],"potential":[249],"importance":[250],"clinical":[253],"response":[254],"during":[255,307],"with":[257,309],"these":[258,332],"drugs.":[259,333],"might":[262],"constitute":[263],"subgroup":[265],"patients":[267],"at":[268,279],"increased":[269],"risk":[270,281],"failure,":[273],"whereas":[274],"possibly":[278],"dose-dependent":[283],"side":[284,305],"effects.":[285],"Although":[286],"needed":[290],"value":[294],"genotyping":[297],"prevention":[300],"failure":[303],"effects":[306],"sertraline,":[312],"findings":[314],"present":[317],"may":[319],"provide":[320],"fundament":[322],"individual":[324],"dosing":[325],"limit":[327],"exposure":[330]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
