{"id":"https://openalex.org/W2462205608","doi":null,"title":"Metabolic effects of metformin addition to chronic glibenclamide treatment in type 2 diabetes.","display_name":"Metabolic effects of metformin addition to chronic glibenclamide treatment in type 2 diabetes.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2462205608","mag":"2462205608","pmid":"https://pubmed.ncbi.nlm.nih.gov/8056129"},"language":"en","primary_location":{"id":"pmid:8056129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8056129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabete & metabolisme","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032203781","display_name":"Saverio Marena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Marena","raw_affiliation_strings":["Institute of Internal Medicine, University of Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine, University of Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036868427","display_name":"Vittorio Tagliaferro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Tagliaferro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039671805","display_name":"G. Montegrosso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Montegrosso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Pagano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pagano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111885503","display_name":"Luca Scaglione","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Scaglione","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111837905","display_name":"Gianfranco Pagano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Pagano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1956,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.92096788,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"20","issue":"1","first_page":"15","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8740000128746033},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.7549999952316284},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7070000171661377},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.6930000185966492},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hepatic-glucose-production","display_name":"hepatic glucose production","score":0.9100000262260437},{"id":"https://openalex.org/keywords/glucose-utilization","display_name":"glucose utilization","score":0.7630000114440918},{"id":"https://openalex.org/keywords/lipemia","display_name":"lipemia","score":0.5049999952316284},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9380000233650208},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.4620000123977661},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.5830000042915344},{"id":"https://openalex.org/keywords/non-obese-patients","display_name":"non-obese patients","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8890856504440308},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.8778625130653381},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8678566217422485},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8496013879776001},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6844142079353333},{"id":"https://openalex.org/C2778808658","wikidata":"https://www.wikidata.org/wiki/Q2975183","display_name":"Glucose clamp technique","level":5,"score":0.6418861150741577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6127444505691528},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5713700652122498},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5373396277427673},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4892313480377197},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.43794792890548706},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.3837096393108368},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.3611435890197754},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8056129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8056129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabete & metabolisme","raw_type":"Clinical Trial"},{"id":"mag:2462205608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8056129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4240640165","https://openalex.org/W2138470202","https://openalex.org/W2043316108","https://openalex.org/W2553630145","https://openalex.org/W4234956512","https://openalex.org/W2176639197","https://openalex.org/W2146552785","https://openalex.org/W4302548949","https://openalex.org/W2048292444","https://openalex.org/W2033842517"],"abstract_inverted_index":{"In":[0],"a":[1,53,75,105,243],"randomized":[2,60],"double-blind":[3],"cross-over":[4],"study":[5,106],"the":[6,80,192,239,297,306],"addition":[7,291],"of":[8,83,107,167],"metformin":[9,227],"to":[10,65,110,221,292],"chronic":[11],"glibenclamide":[12],"treatment":[13,69],"was":[14,101,205,224],"assessed":[15],"conventionally":[16],"(plasma":[17],"glucose":[18,27,116,132,170,189,211],"profile":[19,241],"and":[20,23,141,258,295,308],"HbA1c":[21,142],"measurement)":[22],"with":[24,45,104,185],"an":[25,87,186,259],"euglycaemic-hyperinsulinaemic":[26],"clamp":[28,100,193],"in":[29,59,157,188,245,261,276],"ten":[30],"non":[31],"obese":[32],"(body":[33],"mass":[34],"index":[35],"22.3":[36],"+/-":[37,91,97,119,123,135,144,148,173,177,195,199,229,233,248,252,264,268],"0.5":[38,92],"(+/-":[39],"SE)kg.m-2)":[40],"Type":[41],"2":[42],"diabetic":[43],"patients":[44],"poor":[46],"metabolic":[47,285],"control.":[48],"Metformin":[49,113],"(500":[50],"mg":[51,72],"twice":[52],"day)":[54],"or":[55,161],"placebo":[56],"were":[57,155],"added":[58],"sequence":[61],"for":[62],"6":[63],"weeks":[64],"their":[66],"usual":[67],"sulphonylurea":[68,293],"(glibenclamide":[70],"5":[71],"three":[73],"times":[74],"day,":[76],"before":[77],"meals).":[78],"On":[79],"last":[81],"day":[82],"each":[84],"administration":[85],"period,":[86],"euglycaemic":[88],"(glucose":[89],"5.5":[90],"mmol.l-1),":[93],"hyperinsulinaemic":[94],"(insulin":[95],"698.1":[96],"22.9":[98],"pmol.l-1)":[99],"performed,":[102],"together":[103,184],"insulin":[108,160,214,302],"binding":[109,220],"circulating":[111,222],"monocytes.":[112],"reduced":[114],"fasting":[115,158],"levels":[117],"(6.1":[118],"0.4":[120,124,136],"vs":[121,146,175,197,231,250,266],"6.4":[122],"mmol.l-1,":[125,137,254,270],"P":[126,138,150,181,202,235,255,271],"=":[127,151,203,236,256,272],"0.036),":[128],"mean":[129],"daily":[130],"plasma":[131,159],"concentrations":[133],"(9.2":[134],"<":[139,182],"0.001),":[140,183],"(8.7":[143],"0.3":[145,253],"9.3":[147],"0.2%;":[149],"0.027).":[152],"No":[153],"variations":[154,275],"registered":[156],"body":[162],"weight.":[163],"A":[164],"significant":[165],"reduction":[166,244],"basal":[168],"hepatic":[169,307],"production":[171,212],"(12.8":[172],"2.7":[174],"33.9":[176],"4.5":[178],"mumol.kg-1":[179],"min-1,":[180],"increase":[187,260],"utilization":[190],"during":[191,213],"(33.4":[194],"2.8":[196],"25.9":[198],"1.1":[200],"mumol.kg-1.min-1,":[201],"0.033),":[204],"found":[206],"after":[207,226,289],"metformin,":[208],"whereas":[209],"residual":[210],"infusion":[215],"did":[216],"not":[217],"change.":[218],"Insulin":[219],"monocytes":[223],"higher":[225],"(4.8":[228],"0.9":[230],"3.2":[232],"0.6%,":[234],"0.020),":[237],"while":[238],"lipaemic":[240],"showed":[242],"triglycerides":[246],"(1.2":[247],"0.1":[249,265,269],"1.7":[251],"0.039)":[257],"HDL-cholesterol":[262],"(1.3":[263],"1.0":[267],"0.004)":[273],"without":[274],"total":[277],"cholesterol.":[278],"These":[279],"findings":[280],"offer":[281],"further":[282],"evidence":[283],"that":[284,299],"control":[286],"is":[287],"improved":[288],"biguanide":[290],"treatment,":[294],"support":[296],"hypothesis":[298],"biguanides":[300],"improve":[301],"sensitivity":[303],"both":[304],"at":[305],"peripheral":[309],"(muscular)":[310],"levels,":[311],"as":[312,314],"well":[313],"triglyceride":[315],"metabolism.":[316]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-07-22T00:00:00"}
