{"id":"https://openalex.org/W2462166323","doi":"https://doi.org/10.18632/oncotarget.10417","title":"Transcriptome-wide characterization of the endogenous miR-34A-p53 tumor suppressor network","display_name":"Transcriptome-wide characterization of the endogenous miR-34A-p53 tumor suppressor network","publication_year":2016,"publication_date":"2016-07-06","ids":{"openalex":"https://openalex.org/W2462166323","doi":"https://doi.org/10.18632/oncotarget.10417","mag":"2462166323","pmid":"https://pubmed.ncbi.nlm.nih.gov/27391063","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5226533"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.10417","doi":"https://doi.org/10.18632/oncotarget.10417","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.10417","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10417&path%5B%5D=32913","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10417&path%5B%5D=32913","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071248483","display_name":"Nardin Samuel","orcid":"https://orcid.org/0000-0002-5007-4134","observed_orcids":["https://orcid.org/0000-0002-5007-4134"]},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I112260969"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nardin Samuel","raw_affiliation_strings":["Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada","Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada","Ontario Institute for Cancer Research, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082524303","display_name":"Gavin W. Wilson","orcid":"https://orcid.org/0000-0002-3557-6320","observed_orcids":["https://orcid.org/0000-0002-3557-6320"]},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I112260969"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gavin Wilson","raw_affiliation_strings":["Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, Canada","Ontario Institute for Cancer Research, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103098760","display_name":"Badr Id Said","orcid":"https://orcid.org/0000-0001-9389-1954","observed_orcids":["https://orcid.org/0000-0001-9389-1954"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Badr Id Said","raw_affiliation_strings":["Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045287397","display_name":"Anna Pan","orcid":"https://orcid.org/0000-0002-8019-6730","observed_orcids":["https://orcid.org/0000-0002-8019-6730"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anna Pan","raw_affiliation_strings":["Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082253864","display_name":"Genevi\u00e8ve Deblois","orcid":"https://orcid.org/0000-0002-3067-2807","observed_orcids":["https://orcid.org/0000-0002-3067-2807"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Genevieve Deblois","raw_affiliation_strings":["Princess Margaret Cancer Centre, University Health Network, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Centre, University Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030651983","display_name":"Nicholas William Fischer","orcid":"https://orcid.org/0000-0003-4672-0532","observed_orcids":["https://orcid.org/0000-0003-4672-0532"]},"institutions":[{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nicholas W. Fischer","raw_affiliation_strings":["Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Canada","institution_ids":["https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109748710","display_name":"Roumiana Alexandrova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4405269062","display_name":"Centre for Applied Genomics","ror":"https://ror.org/02z88ma36","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405269062"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Roumiana Alexandrova","raw_affiliation_strings":["The Centre for Applied Genomics (TCAG), Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centre for Applied Genomics (TCAG), Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada","institution_ids":["https://openalex.org/I2801317318","https://openalex.org/I4405269062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017587023","display_name":"Guillermo Casallo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4405269062","display_name":"Centre for Applied Genomics","ror":"https://ror.org/02z88ma36","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405269062"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Guillermo Casallo","raw_affiliation_strings":["The Centre for Applied Genomics (TCAG), Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centre for Applied Genomics (TCAG), Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada","institution_ids":["https://openalex.org/I2801317318","https://openalex.org/I4405269062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078094307","display_name":"Tara Paton","orcid":"https://orcid.org/0000-0003-3212-0173","observed_orcids":["https://orcid.org/0000-0003-3212-0173"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4405269062","display_name":"Centre for Applied Genomics","ror":"https://ror.org/02z88ma36","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405269062"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tara Paton","raw_affiliation_strings":["The Centre for Applied Genomics (TCAG), Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centre for Applied Genomics (TCAG), Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada","institution_ids":["https://openalex.org/I2801317318","https://openalex.org/I4405269062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004938979","display_name":"Mathieu Lupien","orcid":"https://orcid.org/0000-0003-0929-9478","observed_orcids":["https://orcid.org/0000-0003-0929-9478"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mathieu Lupien","raw_affiliation_strings":["Princess Margaret Cancer Centre, University Health Network, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Centre, University Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006919436","display_name":"Jean Gari\u00e9py","orcid":"https://orcid.org/0000-0003-2217-2981","observed_orcids":["https://orcid.org/0000-0003-2217-2981"]},"institutions":[{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jean Gariepy","raw_affiliation_strings":["Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Canada","institution_ids":["https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072404345","display_name":"Daniele Merico","orcid":"https://orcid.org/0000-0002-3728-4401","observed_orcids":["https://orcid.org/0000-0002-3728-4401"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4405269062","display_name":"Centre for Applied Genomics","ror":"https://ror.org/02z88ma36","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405269062"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Daniele Merico","raw_affiliation_strings":["The Centre for Applied Genomics (TCAG), Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centre for Applied Genomics (TCAG), Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada","institution_ids":["https://openalex.org/I2801317318","https://openalex.org/I4405269062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060105528","display_name":"Thomas J. Hudson","orcid":"https://orcid.org/0000-0002-1376-4849","observed_orcids":["https://orcid.org/0000-0002-1376-4849"]},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I112260969"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thomas J. Hudson","raw_affiliation_strings":["Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada","Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, Canada","Ontario Institute for Cancer Research, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090452550","display_name":"David M. Malkin","orcid":"https://orcid.org/0000-0001-5752-9763","observed_orcids":["https://orcid.org/0000-0001-5752-9763"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"David Malkin","raw_affiliation_strings":["Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada","Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada","Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada","institution_ids":["https://openalex.org/I2801317318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5090452550"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"],"apc_list":null,"apc_paid":null,"fwci":0.8333,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71537448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"31","first_page":"49611","last_page":"49622"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-34a","display_name":"miR-34a","score":0.9829999804496765},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-suppressor-network","display_name":"tumor suppressor network","score":0.8500000238418579},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6499999761581421},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5479999780654907},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.7300000190734863},{"id":"https://openalex.org/keywords/germline-tp53-mutation","display_name":"germline TP53 mutation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.4860000014305115},{"id":"https://openalex.org/keywords/non-transformed-cells","display_name":"non-transformed cells","score":0.7279999852180481},{"id":"https://openalex.org/keywords/transcriptome-wide-analysis","display_name":"transcriptome-wide analysis","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7509660720825195},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.7149616479873657},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.6621595025062561},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6299620270729065},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4613483250141144},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.431482195854187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42084574699401855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3908020853996277},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.321367472410202},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22981277108192444},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20833033323287964},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2048323154449463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11462491750717163}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.18632/oncotarget.10417","doi":"https://doi.org/10.18632/oncotarget.10417","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.10417","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10417&path%5B%5D=32913","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5226533","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5226533","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:27391063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27391063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.10417","doi":"https://doi.org/10.18632/oncotarget.10417","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.10417","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10417&path%5B%5D=32913","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4699999988079071,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313290","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54"},{"id":"https://openalex.org/F4320322597","display_name":"Terry Fox Research Institute","ror":"https://ror.org/05vd00053"},{"id":"https://openalex.org/F4320323654","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320336370","display_name":"Ontario Ministry of Research and Innovation","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2462166323.pdf","grobid_xml":"https://content.openalex.org/works/W2462166323.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1970431885","https://openalex.org/W1999746344","https://openalex.org/W2020700496","https://openalex.org/W2037647570","https://openalex.org/W2041714373","https://openalex.org/W2066876408","https://openalex.org/W2067107606","https://openalex.org/W2067192695","https://openalex.org/W2083158631","https://openalex.org/W2090374150","https://openalex.org/W2095909899","https://openalex.org/W2113039629","https://openalex.org/W2140477106","https://openalex.org/W2144137532","https://openalex.org/W2144154026","https://openalex.org/W2147985894","https://openalex.org/W2149792163","https://openalex.org/W2156843318","https://openalex.org/W2170685293","https://openalex.org/W2171407623","https://openalex.org/W2207710635","https://openalex.org/W2413904573"],"related_works":["https://openalex.org/W2144154026","https://openalex.org/W3151821102","https://openalex.org/W2038167014","https://openalex.org/W2349198440","https://openalex.org/W2051663161","https://openalex.org/W7098265241","https://openalex.org/W2113039629","https://openalex.org/W798844222","https://openalex.org/W4388720643","https://openalex.org/W649962276"],"abstract_inverted_index":{"//":[0],"Nardin":[1],"Samuel":[2],"1,":[3,57,63],"2,":[4,64],"3":[5,92],",":[6,11,16,20,24,29,33,37,41,45,49,53,60],"Gavin":[7],"Wilson":[8],"3,":[9,58],"4":[10,59,100],"Badr":[12],"Id":[13],"Said":[14],"2":[15,19,79],"Anna":[17],"Pan":[18],"Genevieve":[21],"Deblois":[22],"5":[23,44,113],"Nicholas":[25],"W.":[26],"Fischer":[27],"6":[28,48,123],"Roumiana":[30],"Alexandrova":[31],"7":[32,36,40,52,133],"Guillermo":[34],"Casallo":[35],"Tara":[38],"Paton":[39],"Mathieu":[42],"Lupien":[43],"Jean":[46],"Gariepy":[47],"Daniele":[50],"Merico":[51],"Thomas":[54],"J.":[55],"Hudson":[56],"David":[61,172],"Malkin":[62],"8":[65,153],"1":[66],"Department":[67,101,124,157],"of":[68,72,75,102,106,109,125,155,158,166,202,208,236,258,331,355,366,381],"Medical":[69],"Biophysics,":[70],"Faculty":[71,105],"Medicine,":[73,107],"University":[74,108,118,165],"Toronto,":[76,77,90,98,110,111,121,131,151,167,168],"Canada":[78,91,99,112,122,132,152,169],"Genetics":[80,142],"and":[81,143,206,277,341,353,386,390],"Genome":[82,144],"Biology":[83],"Program,":[84],"The":[85,134,146,160],"Hospital":[86,147,161],"for":[87,95,136,148,162,304,376],"Sick":[88,149,163],"Children,":[89,150,164],"Ontario":[93],"Institute":[94],"Cancer":[96,116],"Research,":[97],"Molecular":[103],"Genetics,":[104],"Princess":[114],"Margaret":[115],"Centre,":[117],"Health":[119],"Network,":[120],"Physical":[126],"Sciences,":[127],"Sunnybrook":[128],"Research":[129],"Institute,":[130],"Centre":[135],"Applied":[137],"Genomics":[138],"(TCAG),":[139],"Program":[140],"in":[141,219,231,239,262,309,319,363,368],"Biology,":[145],"Division":[154],"Hematology/Oncology,":[156],"Pediatrics,":[159],"Correspondence":[170],"to:":[171],"Malkin,":[173],"email:":[174],"david.malkin@sickkids.ca":[175],"Keywords:":[176],"miR-34A,":[177],"p53,":[178],"TP53,":[179],"cell":[180,269,350],"cycle,":[181],"non-coding":[182],"RNA":[183,326,329],"Received:":[184],"April":[185],"07,":[186],"2016":[187,191,195],"Accepted:":[188],"May":[189],"19,":[190],"Published:":[192],"July":[193],"06,":[194],"ABSTRACT":[196],"microRNA-34A":[197],"is":[198,211,242],"a":[199,320,359,374],"critical":[200],"component":[201],"the":[203,233,255,259,293,305,332,364,378,382,394],"p53":[204],"network":[205],"expression":[207],"miR-":[209,345],"34A":[210],"down-regulated":[212],"by":[213,393],"promoter":[214],"hypermethylation":[215],"or":[216,284],"focal":[217],"deletions":[218],"numerous":[220],"human":[221,310],"cancers.":[222],"Although":[223],"miR-34A":[224,297,317,356,383],"deregulation":[225],"may":[226],"be":[227],"an":[228],"important":[229],"driver":[230],"cancer,":[232],"endogenous":[234,379],"role":[235,380],"this":[237,248],"microRNA":[238],"cellular":[240],"homeostasis":[241],"not":[243],"well":[244,337],"characterized.":[245],"To":[246],"address":[247],"knowledge":[249],"gap,":[250],"we":[251,289,302],"aimed":[252],"to":[253,291,296,323,358],"determine":[254],"transcriptional":[256,294],"landscape":[257],"miR-34A-p53":[260,396],"axis":[261,385],"non-transformed":[263],"cells.":[264],"Using":[265],"primary":[266],"skin-derived":[267],"fibroblast":[268],"lines":[270],"from":[271],"patients":[272],"who":[273,278],"developed":[274],"childhood":[275],"cancers,":[276],"harbor":[279],"either":[280],"germline":[281],"TP53":[282,286,315,339,360],"mutations":[283],"are":[285],"wild":[287],"type,":[288],"sought":[290],"characterize":[292],"response":[295],"modulation.":[298],"Through":[299],"transcriptome-wide":[300],"RNA-Sequencing,":[301],"show":[303],"first":[306],"time":[307],"that":[308],"non-":[311],"transformed":[312],"cells":[313,367],"harboring":[314],"mutations,":[316],"functions":[318],"noncanonical":[321],"manner":[322],"influence":[324],"noncoding":[325],"networks,":[327],"including":[328],"components":[330],"minor":[333],"(U12)":[334],"spliceosome,":[335],"as":[336,338],"-dependent":[340,361],"independent":[342],"epigenetic":[343],"pathways.":[344],"34A-regulated":[346],"transcripts":[347,389],"include":[348],"known":[349],"cycle":[351],"mediators":[352],"abrogation":[354],"leads":[357],"increase":[362],"fraction":[365],"G2/M.":[369],"Collectively,":[370],"these":[371],"results":[372],"provide":[373],"framework":[375],"understanding":[377],"signaling":[384],"identify":[387],"novel":[388],"pathways":[391],"regulated":[392],"essential":[395],"tumor":[397],"suppressor":[398],"network.":[399]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-07-22T00:00:00"}