{"id":"https://openalex.org/W2462015154","doi":null,"title":"Non-Invasive Prenatal Testing","display_name":"Non-Invasive Prenatal Testing","publication_year":2015,"publication_date":"2015-12-11","ids":{"openalex":"https://openalex.org/W2462015154","mag":"2462015154"},"language":"en","primary_location":{"id":"pmh:oai:dergipark.gov.tr:article/158896","doi":null,"is_oa":false,"landing_page_url":"http://dergipark.gov.tr/totm/issue/13164/158896","pdf_url":null,"source":{"id":"https://openalex.org/S4210239751","display_name":"Annals of Medical Research","issn_l":"1300-1744","issn":["1300-1744","2636-7688"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4360969463","host_organization_name":"Inonu University Faculty of Medicine","host_organization_lineage":["https://openalex.org/P4360969463"],"host_organization_lineage_names":["Inonu University Faculty of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\\n Volume: 22, Issue: 2\\n 141-142\\n \\n","raw_type":"info:eu-repo/semantics/article"},"parent_works":[],"lineage":["https://openalex.org/W2462015154"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084269158","display_name":"Cemal Ekici","orcid":"https://orcid.org/0000-0003-1872-3138","observed_orcids":["https://orcid.org/0000-0003-1872-3138"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ekici, Cemal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084269158"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-invasive-prenatal-testing","display_name":"non-invasive prenatal testing","score":0.9980000257492065},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cell-free-fetal-dna","display_name":"cell-free fetal DNA","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prenatal-screening","display_name":"prenatal screening","score":0.9309999942779541},{"id":"https://openalex.org/keywords/amniocentesis","display_name":"amniocentesis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/chorionic-villus-sampling","display_name":"chorionic villus sampling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cordocentesis","display_name":"cordocentesis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.5910000205039978},{"id":"https://openalex.org/keywords/monogenic-diseases","display_name":"monogenic disorders","score":0.5149999856948853},{"id":"https://openalex.org/keywords/ethical-issues","display_name":"ethical considerations","score":0.550000011920929},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/prenatal-termination","display_name":"prenatal termination","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C2777966818","wikidata":"https://www.wikidata.org/wiki/Q473768","display_name":"Amniocentesis","level":5,"score":0.875365674495697},{"id":"https://openalex.org/C2776555163","wikidata":"https://www.wikidata.org/wiki/Q1076497","display_name":"Chorionic villus sampling","level":5,"score":0.824418306350708},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.763523519039154},{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.7585294842720032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7359507083892822},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.6940949559211731},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6531729698181152},{"id":"https://openalex.org/C2776229224","wikidata":"https://www.wikidata.org/wiki/Q844903","display_name":"Trisomy","level":2,"score":0.6187856197357178},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.566818118095398},{"id":"https://openalex.org/C2776352029","wikidata":"https://www.wikidata.org/wiki/Q4686351","display_name":"Advanced maternal age","level":4,"score":0.41560977697372437},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.37346428632736206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1165904700756073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11537793278694153}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dergipark.gov.tr:article/158896","doi":null,"is_oa":false,"landing_page_url":"http://dergipark.gov.tr/totm/issue/13164/158896","pdf_url":null,"source":{"id":"https://openalex.org/S4210239751","display_name":"Annals of Medical Research","issn_l":"1300-1744","issn":["1300-1744","2636-7688"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4360969463","host_organization_name":"Inonu University Faculty of Medicine","host_organization_lineage":["https://openalex.org/P4360969463"],"host_organization_lineage_names":["Inonu University Faculty of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\\n Volume: 22, Issue: 2\\n 141-142\\n \\n","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.org.tr:article/158896","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/tr/pub/totm/issue/13164/158896","pdf_url":null,"source":{"id":"https://openalex.org/S4210239751","display_name":"Annals of Medical Research","issn_l":"1300-1744","issn":["1300-1744","2636-7688"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4360969463","host_organization_name":"Inonu University Faculty of Medicine","host_organization_lineage":["https://openalex.org/P4360969463"],"host_organization_lineage_names":["Inonu University Faculty of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Turgut Ozal Medical Center","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W135339027","https://openalex.org/W2586353389","https://openalex.org/W4363625532","https://openalex.org/W570522060","https://openalex.org/W2154758004","https://openalex.org/W4308531490","https://openalex.org/W2001666053","https://openalex.org/W2068760867"],"abstract_inverted_index":{"The":[0,155,179,344],"rate":[1,278],"of":[2,63,70,73,153,173,176,217,232,243,253,274,279,319,326,348,371,383,450,455,465,488],"newborns":[3],"with":[4,289,298,460],"trisomy":[5,165,287],"21":[6,288],"(Down":[7],"syndrome)":[8],"who":[9],"have":[10],"been":[11],"referred":[12],"to":[13,83,199,220,248,312,341,433,495,543,546,560],"our":[14,573],"pediatric":[15],"newborn":[16],"clinic":[17],"is":[18,29,109,133,351,431,475,510,523],"very":[19],"high.":[20],"This":[21,138],"shows":[22],"that":[23,293,508,551],"prenatal":[24,41,53,107,208,563],"screening":[25,37,62,163,314,318,378,527],"in":[26,76,79,85,97,100,149,168,171,202,214,228,239,259,264,458,529,558,572],"the":[27,68,71,98,101,116,120,130,136,141,150,177,229,240,257,272,304,327,352,434,447,453,463,500,506,570],"region":[28],"not":[30,511],"carried":[31],"out":[32],"well.":[33],"Prenatal":[34],"diagnosis":[35,42,54,108,443],"and":[36,49,51,81,88,118,145,269,281,301,356,368,436,452,502,517],"methods":[38,43,565],"include":[39],"invasive":[40,207,562],"(amniocentesis,":[44],"chorionic":[45],"villus":[46],"sampling":[47],"(CVS),":[48],"cordocentesis)":[50],"non-invasive":[52],"(NIPT)":[55],"which":[56,474],"cell":[57,308],"free":[58],"fetal":[59,74,316],"DNA":[60,75],"(cffDNA)":[61],"maternal":[64,77,188],"blood":[65,78,126,170,321],"samples.":[66],"After":[67],"discovery":[69],"signs":[72],"1997":[80],"parallel":[82],"advancements":[84],"molecular":[86],"genetics":[87],"technology,":[89],"NIPT":[90,290,426,466,522,553],"has":[91,427],"become":[92,331],"a":[93,110,183,277,332,471,524],"widely":[94],"used":[95],"method":[96,139,291,350,490,528,557],"world":[99],"last":[102],"few":[103,184,472],"years":[104],"(1).":[105],"Non-invasive":[106],"test":[111,156,180],"without":[112,303],"risks":[113],"both":[114,267],"for":[115,119,135,164,250,256,306,315,322,375,479,514,569],"mother":[117,435],"fetus.":[121,178],"A":[122],"4-5":[123],"cc":[124],"peripheral":[125],"sample":[127],"taken":[128],"from":[129],"mother's":[131,169,320],"arm":[132],"sufficient":[134],"diagnosis.":[137],"scans":[140],"13,":[142],"18,":[143],"21,":[144],"sex":[146],"chromosomes":[147],"(X/Y)":[148],"8th":[151,448],"week":[152,449],"pregnancy.":[154,244],"involves":[157],"whole":[158],"genome":[159],"scanning":[160],"or":[161,166],"targeted":[162],"monosomy":[167],"search":[172],"cffDNA":[174],"fragments":[175],"results":[181,258,297,370,464],"within":[182,470],"days,":[185,473],"thus":[186],"eliminating":[187],"anxiety":[189],"and,":[190],"if":[191],"there":[192,335,483],"are":[193,336,484,541],"pathological":[194],"results,":[195],"providing":[196],"enough":[197],"time":[198],"terminate":[200],"pregnancy":[201,218,233,451],"its":[203,493,518],"early":[204,442,445,456],"weeks.":[205],"Other":[206],"tests":[209],"can":[210,225,236,467],"only":[211],"be":[212,226,237,468,547,567],"applied":[213,238,526],"later":[215],"weeks":[216,231,242,255],"compared":[219],"NIPT.":[221],"For":[222],"instance,":[223],"CVS":[224,268],"done":[227],"11th-12th":[230],"while":[234,438],"amniocentesis":[235,270],"16th-18th":[241],"Still,":[245],"patients":[246,571],"need":[247,305],"wait":[249],"an":[251,555],"average":[252],"3":[254],"these":[260],"tests.":[261],"Moreover,":[262],"even":[263],"experienced":[265],"hands,":[266],"carry":[271],"risk":[273],"abortion":[275],"at":[276],"1/50":[280],"1/200,":[282],"respectively.":[283],"Recent":[284],"studies":[285,339,374],"on":[286],"show":[292],"practitioners":[294],"may":[295],"achieve":[296],"high":[299,520],"sensitivity":[300],"specificity":[302,369],"long":[307],"culture.":[309],"In":[310,533],"addition":[311,559],"frequent":[313],"trisomy,":[317],"single":[323],"gene":[324],"disorders":[325],"fetus":[328,437],"will":[329,566],"eventually":[330],"routine":[333],"practice;":[334],"already":[337],"many":[338],"underway":[340],"this":[342,349,362,480,489],"end.":[343],"most":[345],"controversial":[346],"aspect":[347],"ethical":[353],"aspect;":[354],"geneticists":[355],"obstetricians":[357],"share":[358],"different":[359,373],"opinions":[360],"about":[361,498],"issue":[363],"(2).":[364],"Table":[365],"1.":[366],"Sensitivity":[367],"eight":[372],"Down":[376],"syndrome":[377],"by":[379],"NIPT.Authors":[380],"\u2013":[381],"Year":[382],"PublicationMethodPFPNFNSensitivitySpecificityEnrich":[384],"et":[385,389,393,397,401,405,409,413],"al.":[386,390,394,398,402,406,410,414],"2011(3)Whole":[387],"Genome390410110099.7Palomaki":[388],"2011(4)Whole":[391],"Genome21231471399.699.8Bianchi":[392],"2012(5)Whole":[395],"Genome8904040100100Ashoor":[396],"2012(6)Targeted":[399],"Screening5002970100100Sparks":[400],"2012(7)Targeted":[403],"Screening3601230100100Norton":[404],"2012(8)Targeted":[407],"Screening8102888110099.97Futch":[408],"2013(9)Whole":[411],"Genome15425515198.7299.98Liang":[412],"2011(10)Whole":[415],"Genome4003720100100P:":[416],"Positive;":[417],"FP:":[418],"False":[419,424],"positive;":[420],"N:":[421],"Negative;":[422],"FN:":[423],"negative":[425],"certain":[428],"advantages;":[429],"it":[430,439,509],"harmless":[432],"also":[440,485],"provides":[441],"as":[444,446,492,554],"option":[454],"termination":[457],"cases":[459],"aneuploidy.":[461],"Besides,":[462],"obtained":[469],"another":[476],"plus":[477],"side":[478],"method.":[481],"Whereas,":[482],"some":[486,530,536],"disadvantages":[487],"such":[491],"inability":[494],"provide":[496],"information":[497],"all":[499],"structural":[501],"numerical":[503],"chromosome":[504],"abnormalities,":[505],"fact":[507],"100%":[512],"reliable":[513],"common":[515],"trisomies,":[516],"comparatively":[519],"cost.":[521],"routinely":[525],"developed":[531],"countries.":[532],"Turkey,":[534],"through":[535],"local":[537],"private":[538],"laboratories,":[539],"samples":[540],"sent":[542],"centres":[544],"abroad":[545],"studied.":[548],"I":[549],"believe":[550],"offering":[552],"alternative":[556],"other":[561],"diagnostic":[564],"beneficial":[568],"region.":[574]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2025-10-10T00:00:00"}