{"id":"https://openalex.org/W2461908677","doi":null,"title":"[Concentration of IL-18 and PGE2 in synovial fluid in patients with osteoarthritis and its significance].","display_name":"[Concentration of IL-18 and PGE2 in synovial fluid in patients with osteoarthritis and its significance].","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W2461908677","mag":"2461908677","pmid":"https://pubmed.ncbi.nlm.nih.gov/17213584"},"language":"zh","primary_location":{"id":"pmid:17213584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17213584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102719420","display_name":"Chengzhong Peng","orcid":"https://orcid.org/0000-0003-4886-7466","observed_orcids":["https://orcid.org/0000-0003-4886-7466"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng-zhong Peng","raw_affiliation_strings":["Department of Orthopaedics, Second Xiangya Hospital, Central South University, Changsha 410011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Second Xiangya Hospital, Central South University, Changsha 410011, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110378156","display_name":"Cao Jian-min","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-min Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Tao Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007046565","display_name":"Cheng Yun Peng","orcid":"https://orcid.org/0000-0003-3303-906X","observed_orcids":["https://orcid.org/0000-0003-3303-906X","https://orcid.org/0009-0003-4642-0609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheng Peng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042656907","display_name":"Hongbo Yang","orcid":"https://orcid.org/0000-0003-2985-8265","observed_orcids":["https://orcid.org/0000-0003-2985-8265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-bo Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441917","display_name":"Xiang 'Anthony' Chen","orcid":"https://orcid.org/0000-0002-2499-8261","observed_orcids":["https://orcid.org/0000-0002-2499-8261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiang Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081989594","display_name":"Jian-zhen Fang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-zhen Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6256,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.72706505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"31","issue":"6","first_page":"862","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9430000185966492},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/osteoarthritis-pathogenesis","display_name":"osteoarthritis pathogenesis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6539999842643738},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.8264505863189697},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7859574556350708},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7852050065994263},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.6453969478607178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6409249305725098},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46668514609336853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40802842378616333},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40317463874816895},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22104626893997192},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17213584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17213584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences","raw_type":"English Abstract"},{"id":"mag:2461908677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17213584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2078005648","https://openalex.org/W2467587265","https://openalex.org/W2356998560","https://openalex.org/W2130406443","https://openalex.org/W1985069706","https://openalex.org/W3042714686","https://openalex.org/W2999628533","https://openalex.org/W3043286221","https://openalex.org/W6939676402","https://openalex.org/W2415963158"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"detect":[2],"the":[3,18,91,100,110,122,126,132,144,163,176,182,191,203],"concentrations":[4,83],"of":[5,20,55,84,107,129,199,205],"interleukin-18":[6],"(IL-18)":[7],"and":[8,15,22,30,47,77,86,117,139,170,185,207],"prostaglandin":[9],"E2(PGE2)":[10],"in":[11,24,35,88,109,121,131,143,153,175,181,190,194,214],"synovial":[12,36],"fluid":[13,37],"(SF),":[14],"to":[16],"determine":[17],"role":[19,213],"IL-18":[21,29,56,76,85,108,148,169,200],"PGE2":[23,31,64,78,87,130,152,171],"osteoarthritis":[25],"(OA)":[26],"pathogenesis.":[27,196,216],"METHODS:":[28],"were":[32,94],"measured":[33],"concurrently":[34],"samples":[38],"from":[39,48,90,99],"54":[40],"patients":[41],"with":[42,151],"knee":[43],"OA":[44,92,123,145,164,177,195,215],"(OA":[45],"group)":[46],"9":[49],"controls":[50],"(control":[51],"group).":[52],"Quantitative":[53],"determination":[54],"was":[57,65,79,113,135,149],"performed":[58],"by":[59,67],"enzyme-linked":[60,69],"immunosorbent":[61,70],"assay":[62],"(ELISA).":[63],"examined":[66],"inhibitory":[68],"assay.":[71],"A":[72],"linear":[73,155],"regression":[74],"between":[75],"analysed.":[80],"RESULTS:":[81],"The":[82,104,197],"SF":[89],"group":[93,102,112,124,134,146,178],"significantly":[95,173],"higher":[96,174],"than":[97,179],"those":[98,180],"control":[101,111,133,159,183],"(P<0.01).":[103,147],"average":[105,127],"value":[106,128],"(28.768+/-13.575)":[114],"x":[115,119,137,141],"10(-9)ng/L,":[116,138],"(72.303+/-40.130)":[118],"10(-9)ng/L":[120,142],"(P<0.01);":[125],"(24.697+/-7.814)":[136],"(42.302+/-23.818)":[140],"related":[150],"a":[154],"curve":[156],"fashion":[157],"(the":[158],"group:":[160,165],"r=0.76,":[161],"P<0.001;":[162],"r=0.94,":[166],"P<0.001).":[167],"CONCLUSION:":[168],"are":[172],"group,":[184],"they":[186],"might":[187,201,209],"take":[188],"part":[189],"cartilage":[192],"degradation":[193],"increase":[198,204],"induce":[202],"PGE2,":[206],"that":[208],"play":[210],"an":[211],"important":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
