{"id":"https://openalex.org/W2461784802","doi":null,"title":"[Development of antihypertensive drug consumption in the Toulouse University Regional Hospital Center from 1981 to 1989].","display_name":"[Development of antihypertensive drug consumption in the Toulouse University Regional Hospital Center from 1981 to 1989].","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2461784802","mag":"2461784802","pmid":"https://pubmed.ncbi.nlm.nih.gov/2020923"},"language":"fr","primary_location":{"id":"pmid:2020923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2020923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapie","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"F Rolland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F Rolland","raw_affiliation_strings":["Service de Pharmacologie M\u00e9dicale et Clinique, Centre Hospitalier Universitaire, Facult\u00e9 de M\u00e9decine, Toulouse"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Pharmacologie M\u00e9dicale et Clinique, Centre Hospitalier Universitaire, Facult\u00e9 de M\u00e9decine, Toulouse","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111484702","display_name":"J Lafont","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Lafont","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091020739","display_name":"Jean\u2010Louis Montastruc","orcid":"https://orcid.org/0000-0001-6341-6001","observed_orcids":["https://orcid.org/0000-0001-6341-6001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Montastruc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019765742","display_name":"Paul Montastruc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Montastruc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40756714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"1","first_page":"45","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12664","display_name":"Clinical practice guidelines implementation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14020","display_name":"General Medicine and Therapeutics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.9440000057220459},{"id":"https://openalex.org/keywords/drug-use","display_name":"drug use","score":0.8700000047683716},{"id":"https://openalex.org/keywords/prescribing-trends","display_name":"prescribing trends","score":0.4959999918937683},{"id":"https://openalex.org/keywords/converting-enzyme-inhibitors","display_name":"converting enzyme inhibitors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":1.0},{"id":"https://openalex.org/keywords/diuretics","display_name":"diuretics","score":0.8999999761581421},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8790000081062317},{"id":"https://openalex.org/keywords/alpha-blockers","display_name":"alpha-blockers","score":0.7590000033378601},{"id":"https://openalex.org/keywords/vasodilators","display_name":"vasodilators","score":0.902999997138977},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.5199999809265137},{"id":"https://openalex.org/keywords/toulouse","display_name":"Toulouse","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2780192228","wikidata":"https://www.wikidata.org/wiki/Q575890","display_name":"Antihypertensive drug","level":3,"score":0.7039236426353455},{"id":"https://openalex.org/C2778176773","wikidata":"https://www.wikidata.org/wiki/Q2976049","display_name":"Drug class","level":3,"score":0.5934873223304749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5846992135047913},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5310609340667725},{"id":"https://openalex.org/C30772137","wikidata":"https://www.wikidata.org/wiki/Q5164762","display_name":"Consumption (sociology)","level":2,"score":0.48478883504867554},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45930182933807373},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.4586380422115326},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.43198662996292114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37118226289749146},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.26840007305145264},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1466999053955078},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004363","descriptor_name":"Drug Utilization","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D005602","descriptor_name":"France","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006785","descriptor_name":"Hospitals, University","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2020923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2020923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapie","raw_type":"English Abstract"},{"id":"mag:2461784802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2020923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1888154667","https://openalex.org/W1991507588","https://openalex.org/W2313843111","https://openalex.org/W2470229101","https://openalex.org/W2352885359","https://openalex.org/W2056513202","https://openalex.org/W2411376073","https://openalex.org/W1989608146","https://openalex.org/W2145741064","https://openalex.org/W1985388908"],"abstract_inverted_index":{"Eighties":[0],"were":[1],"characterized":[2],"by":[3,90],"the":[4,23,37,44,91],"introduction":[5,92],"of":[6,11,25,33,71,86,93,108],"two":[7],"new":[8],"pharmacological":[9],"class":[10],"antihypertensive":[12,29,34,110],"drugs":[13,35,111],"[converting":[14],"enzyme":[15],"inhibitors":[16],"(CEI)":[17],"and":[18,22,57,95],"calcium":[19,100],"channel":[20,101],"blockers]":[21],"publication":[24],"several":[26],"large":[27],"scale":[28],"trials.":[30],"The":[31,83],"consumption":[32,49,107],"at":[36],"Toulouse":[38],"Universitary":[39],"Hospital":[40],"was":[41,88],"evaluated":[42],"during":[43,75],"ten":[45],"last":[46],"years.":[47],"Total":[48],"remained":[50,73],"stable":[51,74],"until":[52],"1985":[53],"(560,000":[54],"pinch":[55],"units)":[56],"raised":[58],"to":[59,66,115],"650,000":[60],"in":[61,68,99,122],"1988.":[62],"This":[63],"number":[64],"decreased":[65],"580,000":[67],"1989.":[69,123],"Consumption":[70],"diuretics":[72],"these":[76],"years":[77],"whereas":[78],"beta-blocking":[79],"agents":[80],"slightly":[81],"decreased.":[82],"global":[84],"increase":[85],"prescription":[87],"explained":[89],"CEI":[94],"a":[96],"marked":[97],"rise":[98],"blockers":[102],"from":[103,113],"1986.":[104],"In":[105],"contrast,":[106],"central":[109],"crushed":[112],"1982":[114],"equal":[116],"vasodilators":[117],"(direct":[118],"+":[119],"alpha-blocking":[120],"agents)":[121]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}