{"id":"https://openalex.org/W2461667014","doi":"https://doi.org/10.1139/g89-061","title":"Model systems for aging research: syncretic concepts and diversity of mechanisms","display_name":"Model systems for aging research: syncretic concepts and diversity of mechanisms","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2461667014","doi":"https://doi.org/10.1139/g89-061","mag":"2461667014","pmid":"https://pubmed.ncbi.nlm.nih.gov/2687106"},"language":"en","primary_location":{"id":"doi:10.1139/g89-061","doi":"https://doi.org/10.1139/g89-061","is_oa":false,"landing_page_url":"https://doi.org/10.1139/g89-061","pdf_url":null,"source":{"id":"https://openalex.org/S170991295","display_name":"Genome","issn_l":"0831-2796","issn":["0831-2796","1480-3321"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010384852","display_name":"Robert J. Shmookler Reis","orcid":"https://orcid.org/0000-0002-4691-0734","observed_orcids":["https://orcid.org/0000-0002-4691-0734"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert J. Shmookler Reis","raw_affiliation_strings":["Department of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010384852"],"corresponding_institution_ids":["https://openalex.org/I79620101"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.27173913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"31","issue":"1","first_page":"406","last_page":"412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9559999704360962},{"id":"https://openalex.org/keywords/model-organisms","display_name":"model organisms","score":0.8190000057220459},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.8840000033378601},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/molecular-mechanisms-of-aging","display_name":"molecular mechanisms of aging","score":0.6930000185966492},{"id":"https://openalex.org/keywords/biochemical-processes","display_name":"biochemical processes","score":0.4749999940395355},{"id":"https://openalex.org/keywords/germline","display_name":"germline","score":0.8109999895095825},{"id":"https://openalex.org/keywords/comparative-biology","display_name":"comparative biology","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.804021954536438},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.7441627979278564},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6001027822494507},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5405513048171997},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.536766767501831},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.494549959897995},{"id":"https://openalex.org/C2908780919","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Cellular Aging","level":4,"score":0.49049705266952515},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.46484699845314026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45452678203582764},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.4425482749938965},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.4398321807384491},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.4011591672897339},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3528153896331787},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.34305110573768616},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.21241992712020874},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16485899686813354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14415600895881653},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007448","descriptor_name":"Invertebrates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1139/g89-061","doi":"https://doi.org/10.1139/g89-061","is_oa":false,"landing_page_url":"https://doi.org/10.1139/g89-061","pdf_url":null,"source":{"id":"https://openalex.org/S170991295","display_name":"Genome","issn_l":"0831-2796","issn":["0831-2796","1480-3321"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome","raw_type":"journal-article"},{"id":"pmid:2687106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2687106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3298002448","display_name":null,"funder_award_id":"AG-03787","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2115316118","https://openalex.org/W2067288438","https://openalex.org/W572993034","https://openalex.org/W2466333719","https://openalex.org/W2735470975","https://openalex.org/W3092372674","https://openalex.org/W2883978951","https://openalex.org/W2422933061","https://openalex.org/W2084965055","https://openalex.org/W2999016958"],"abstract_inverted_index":{"A":[0,15],"variety":[1],"of":[2,12,17,23,31,44],"very":[3],"different":[4,60,76],"phenomena":[5],"have":[6,64],"been":[7],"subsumed":[8],"under":[9],"the":[10,24,29,67,82],"heading":[11],"\"aging\"":[13],"research.":[14],"review":[16],"recent":[18],"experimental":[19],"data,":[20],"in":[21,75,79],"several":[22],"best-studied":[25],"model":[26],"systems":[27,53],"for":[28],"investigation":[30],"aging,":[32],"indicates":[33],"that":[34,59],"molecular":[35],"changes":[36],"which":[37],"are":[38,47],"putative":[39],"or":[40,72],"demonstrated":[41],"proximal":[42],"causes":[43],"senescent":[45],"deterioration":[46],"generally":[48],"not":[49],"shared":[50],"by":[51],"other":[52],"examined.":[54],"It":[55],"is":[56],"thus":[57],"argued":[58],"aberrant":[61],"biochemical":[62],"processes":[63],"evolved":[65],"as":[66],"\"weakest":[68],"link\"":[69],"limiting":[70],"longevity":[71],"intermeiotic":[73],"interval":[74],"systems,":[77],"although":[78],"each":[80],"case":[81],"germ":[83],"line":[84],"must":[85],"be":[86],"exempted.":[87]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
