{"id":"https://openalex.org/W2461621376","doi":null,"title":"Volume substitution and treatment with prostaglandin E1 in a porcine model of endotoxaemia-induced pulmonary and cardiovascular failure.","display_name":"Volume substitution and treatment with prostaglandin E1 in a porcine model of endotoxaemia-induced pulmonary and cardiovascular failure.","publication_year":1987,"publication_date":"1987-03-01","ids":{"openalex":"https://openalex.org/W2461621376","mag":"2461621376","pmid":"https://pubmed.ncbi.nlm.nih.gov/3300118"},"language":"en","primary_location":{"id":"pmid:3300118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3300118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta chirurgica Scandinavica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032881547","display_name":"J. Modig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Modig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065987700","display_name":"Ted Samuelsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Samuelsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111595101","display_name":"R. Sandin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Sandin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4688,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.89429876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"153","issue":"3","first_page":"165","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.05999999865889549,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e1","display_name":"prostaglandin E1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/volume-substitution","display_name":"volume substitution","score":0.6779999732971191},{"id":"https://openalex.org/keywords/albumin-infusion","display_name":"albumin infusion","score":0.8569999933242798},{"id":"https://openalex.org/keywords/pulmonary-hemodynamics","display_name":"pulmonary hemodynamics","score":0.8500000238418579},{"id":"https://openalex.org/keywords/pulmonary-vascular-resistance","display_name":"pulmonary vascular resistance","score":0.843999981880188},{"id":"https://openalex.org/keywords/oxygen-delivery","display_name":"oxygen delivery","score":0.6110000014305115},{"id":"https://openalex.org/keywords/venous-admixture","display_name":"venous admixture","score":0.7730000019073486},{"id":"https://openalex.org/keywords/extravascular-lung-water","display_name":"extravascular lung water","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.7120000123977661},{"id":"https://openalex.org/keywords/base-excess","display_name":"base excess","score":0.9039999842643738},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.6060000061988831},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9090526700019836},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6348641514778137},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.5990964770317078},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5872772932052612},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5692493915557861},{"id":"https://openalex.org/C2779837120","wikidata":"https://www.wikidata.org/wiki/Q579348","display_name":"Prostaglandin E1","level":2,"score":0.5460541248321533},{"id":"https://openalex.org/C35207712","wikidata":"https://www.wikidata.org/wiki/Q190402","display_name":"Central venous pressure","level":4,"score":0.5189658999443054},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5096063613891602},{"id":"https://openalex.org/C86257020","wikidata":"https://www.wikidata.org/wiki/Q809826","display_name":"Base excess","level":2,"score":0.48480549454689026},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.45761340856552124},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.4439314007759094},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4225034713745117},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39358168840408325},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.26050132513046265},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.09740427136421204}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3300118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3300118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta chirurgica Scandinavica","raw_type":"Journal Article"},{"id":"mag:2461621376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3300118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418837338","https://openalex.org/W2013554169","https://openalex.org/W2412698844","https://openalex.org/W2033783508","https://openalex.org/W2002851538","https://openalex.org/W2053830542","https://openalex.org/W4299783108","https://openalex.org/W2417547275","https://openalex.org/W2067933700","https://openalex.org/W2026331711"],"abstract_inverted_index":{"The":[0,104,148],"effects":[1],"of":[2,23,101,138],"prostaglandin":[3],"E1":[4],"(PGE1)":[5],"and":[6,14,25,48,60,68,73,95,111,141,166],"volume":[7,154,173],"substitution":[8],"(5%":[9],"albumin)":[10],"on":[11],"pulmonary":[12,24,94,106,165],"haemodynamics":[13],"oxygen":[15,139],"transport":[16],"were":[17],"evaluated":[18],"in":[19,52,63,122,163,180],"a":[20,177],"porcine":[21],"model":[22],"cardiovascular":[26,96,167],"failure.":[27,168],"Albumin":[28],"was":[29,90,125,130],"infused":[30],"i.v.":[31],"to":[32,171],"maintain":[33],"baseline":[34],"mean":[35],"left":[36],"atrial":[37],"pressure":[38],"throughout":[39],"the":[40,120,145],"experiments.":[41],"Ten":[42],"pigs":[43,75,81],"received":[44],"endotoxin":[45],"+":[46],"albumin":[47],"showed":[49],"ten-fold":[50],"increase":[51,121],"venous":[53,123],"admixture,":[54],"90%":[55],"increased":[56,115],"extravascular":[57,112],"lung":[58,113],"water":[59,114],"25%":[61],"fall":[62],"cardiac":[64],"output.":[65],"Oxygen":[66],"delivery":[67,140],"base":[69,142],"excess":[70],"decreased":[71],"significantly":[72],"four":[74],"died.":[76],"In":[77],"ten":[78],"other":[79],"endotoxin-albumin-treated":[80],"PGE1":[82,134,169],"infusion":[83],"(0.25":[84],"micrograms":[85],"X":[86,88],"kg-1":[87],"min-1)":[89],"begun":[91],"after":[92],"established":[93],"dysfunction,":[97],"for":[98],"closer":[99],"mimicking":[100],"clinical":[102,149],"use.":[103],"raised":[105],"vascular":[107],"resistance":[108],"thereafter":[109],"normalized":[110],"by":[116],"only":[117],"15%,":[118],"but":[119],"admixture":[124],"not":[126,160],"influenced.":[127],"Cardiac":[128],"output":[129],"maintained":[131],"at":[132],"baseline.":[133],"prevented":[135],"further":[136],"derangement":[137],"excess.":[143],"All":[144],"animals":[146],"survived.":[147],"implications":[150],"may":[151,175],"be":[152,176],"that":[153],"infusion,":[155],"even":[156],"optimally":[157],"titrated,":[158],"is":[159],"optimum":[161,172],"treatment":[162,174],"endotoxemic":[164],"added":[170],"useful":[178],"adjuvant":[179],"endotoxaemia.":[181]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
